(19 nodes) Aorta morphogenesis network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SEC24B	SEC24 homolog B, COPII coat complex component. (1261 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	TFAP2B	Transcription factor AP-2 beta. (476 aa)
	FOXH1	Forkhead box H1. (360 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
	TBX2	T-box transcription factor 2. (771 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (569 aa)
	SRF	Serum response factor. (509 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	PROX1	Prospero homeobox 1. (734 aa)
	FKBP10	Peptidylprolyl isomerase. (574 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	SIX1	SIX homeobox 1. (284 aa)
	ENG	Endoglin. (649 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2993 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMPR1A	ENSCHIP00000033488	ENSCHIP00000000640	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.415
ACVRL1	ENG	ENSCHIP00000033488	ENSCHIP00000033223	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.846
BMPR1A	ACVRL1	ENSCHIP00000000640	ENSCHIP00000033488	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.415
BMPR1A	ENG	ENSCHIP00000000640	ENSCHIP00000033223	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.441
CHD7	FGF8	ENSCHIP00000008650	ENSCHIP00000016903	Chromodomain helicase DNA binding protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.509
DLL4	HES1	ENSCHIP00000014302	ENSCHIP00000018538	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.695
DLL4	HEY2	ENSCHIP00000014302	ENSCHIP00000033371	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif 2.	0.889
DLL4	JAG1	ENSCHIP00000014302	ENSCHIP00000023437	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.500
ENG	ACVRL1	ENSCHIP00000033223	ENSCHIP00000033488	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.846
ENG	BMPR1A	ENSCHIP00000033223	ENSCHIP00000000640	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.441
EYA1	FGF8	ENSCHIP00000025106	ENSCHIP00000016903	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
EYA1	JAG1	ENSCHIP00000025106	ENSCHIP00000023437	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.575
EYA1	SIX1	ENSCHIP00000025106	ENSCHIP00000029952	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 1.	0.961
FGF8	CHD7	ENSCHIP00000016903	ENSCHIP00000008650	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Chromodomain helicase DNA binding protein 7.	0.509
FGF8	EYA1	ENSCHIP00000016903	ENSCHIP00000025106	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.534
FGF8	FOXH1	ENSCHIP00000016903	ENSCHIP00000014519	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Forkhead box H1.	0.551
FOXH1	FGF8	ENSCHIP00000014519	ENSCHIP00000016903	Forkhead box H1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.551
HES1	DLL4	ENSCHIP00000018538	ENSCHIP00000014302	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.695
HES1	JAG1	ENSCHIP00000018538	ENSCHIP00000023437	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.791
HEY2	DLL4	ENSCHIP00000033371	ENSCHIP00000014302	Hes related family bHLH transcription factor with YRPW motif 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.889