STRINGSTRING
DLG5 DLG5 RC3H1 RC3H1 TNFSF13B TNFSF13B TNFSF9 TNFSF9 VSIR VSIR IL6ST IL6ST CTLA4 CTLA4 EFNB1 EFNB1 FADD FADD HHLA2 HHLA2 SLAMF1 SLAMF1 CD80 CD80 CD81 CD81 LOC102184087 LOC102184087 ENSCHIP00000005724 ENSCHIP00000005724 NCKAP1L NCKAP1L ENSCHIP00000006184 ENSCHIP00000006184 DLG1 DLG1 TNFRSF9 TNFRSF9 NCK2 NCK2 IL27 IL27 FOXJ1 FOXJ1 IL23A IL23A DHPS DHPS SPTA1 SPTA1 TGFBR2 TGFBR2 PRKAR1A PRKAR1A IL12RB1 IL12RB1 TFRC TFRC IL12RB2 IL12RB2 PPP3CA PPP3CA LOC102187998 LOC102187998 BCL6 BCL6 TWSG1 TWSG1 ZP4 ZP4 TNFRSF21 TNFRSF21 CEBPB CEBPB ENSCHIP00000031738 ENSCHIP00000031738 ERBB2 ERBB2 ZBTB7B ZBTB7B SOS2 SOS2 CTNNB1 CTNNB1 NDFIP1 NDFIP1 IGFBP2 IGFBP2 KITLG KITLG CLEC4G CLEC4G RAC2 RAC2 DLG2 DLG2 IL2 IL2 CD28 CD28 IL15 IL15 IL1B IL1B PDCD1LG2 PDCD1LG2 CBLB CBLB LRRC32 LRRC32 AIF1 AIF1 LOC102180339 LOC102180339 SELENOK SELENOK SHH SHH SH3RF1 SH3RF1 GLMN GLMN IL21 IL21 PYCARD PYCARD IL12A IL12A GPNMB GPNMB PTPRC PTPRC STAT5A STAT5A ARG1 ARG1 MAD1L1 MAD1L1 PELI1 PELI1 ZP3 ZP3 STAT5B STAT5B CORO1A CORO1A ENSCHIP00000024183 ENSCHIP00000024183 BMP4 BMP4 LRRC1 LRRC1 IL18 IL18 CARD11 CARD11 IGF2 IGF2 ANXA1 ANXA1 LOC102183203 LOC102183203 GPAM GPAM SASH3 SASH3 TNFRSF1B TNFRSF1B BTNL2 BTNL2 TMEM131L TMEM131L PTPN6 PTPN6 CD6 CD6 IRF1 IRF1 IDO1 IDO1 TNFSF4 TNFSF4 LOC108638256 LOC108638256 LOC108633234 LOC108633234 VTCN1 VTCN1 LEP LEP LOC102168673 LOC102168673 SCRIB SCRIB IL4 IL4 CCDC88B CCDC88B IGF1 IGF1 SOS1 SOS1 MARCHF7 MARCHF7 TYK2 TYK2 IL20RB IL20RB RIPK2 RIPK2 LOC102187672 LOC102187672 CCL19 CCL19 LGALS7 LGALS7 RASAL3 RASAL3 HES1 HES1 LOC106503912 LOC106503912 CD274 CD274 ARG2 ARG2 HAVCR2 HAVCR2 SLC7A1 SLC7A1 IL12B IL12B TNFRSF13C TNFRSF13C BMI1 BMI1 IHH IHH RIPK3 RIPK3 PLA2G2F PLA2G2F CRTAM CRTAM PRKCQ PRKCQ CD86 CD86 ENSCHIP00000015226 ENSCHIP00000015226 TRAF6 TRAF6 TSPAN32 TSPAN32 MAPK8IP1 MAPK8IP1 IL27RA IL27RA BID BID PTPN22 PTPN22 FOXP3 FOXP3 IL4I1 IL4I1 PAWR PAWR AGER AGER CASP3 CASP3 VSIG4 VSIG4 ITCH ITCH NCK1 NCK1 CD3E CD3E RPS3 RPS3 SYK SYK TNFSF18 TNFSF18 TGFB1 TGFB1 LGALS3 LGALS3 LOC102189615 LOC102189615
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
RC3H1Ring finger and CCCH-type domains 1. (1123 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
TNFSF9TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa)
VSIRV-set immunoregulatory receptor. (312 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (373 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
HHLA2HERV-H LTR-associating 2. (419 aa)
SLAMF1Ig-like domain-containing protein. (338 aa)
CD80CD80 molecule. (302 aa)
CD81Tetraspanin. (236 aa)
LOC102184087Galectin. (342 aa)
ENSCHIP00000005724Uncharacterized protein. (62 aa)
NCKAP1LNCK associated protein 1 like. (1178 aa)
ENSCHIP00000006184Uncharacterized protein. (96 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
TNFRSF9TNF receptor superfamily member 9. (259 aa)
NCK2Cytoplasmic protein. (376 aa)
IL27Interleukin 27. (242 aa)
FOXJ1Forkhead box J1. (421 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
DHPSUncharacterized protein. (369 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2402 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (730 aa)
TFRCTransferrin receptor. (790 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (877 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
LOC102187998Ig-like domain-containing protein. (262 aa)
BCL6BCL6 transcription repressor. (706 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ZP4Zona pellucida glycoprotein 4. (531 aa)
TNFRSF21TNF receptor superfamily member 21. (652 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
ENSCHIP00000031738Galectin. (224 aa)
ERBB2Receptor protein-tyrosine kinase. (1250 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (539 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CTNNB1Catenin beta 1. (781 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
IGFBP2Uncharacterized protein. (326 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
CLEC4GC-type lectin domain family 4 member G. (291 aa)
RAC2Rac family small GTPase 2. (192 aa)
DLG2Discs large MAGUK scaffold protein 2. (901 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
CD28CD28 molecule. (228 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (296 aa)
CBLBCbl proto-oncogene B. (983 aa)
LRRC32Leucine rich repeat containing 32. (710 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
LOC102180339Galectin-7. (139 aa)
SELENOKSelenoprotein K. (85 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
SH3RF1SH3 domain containing ring finger 1. (840 aa)
GLMNGlomulin, FKBP associated protein. (592 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (157 aa)
PYCARDPYD and CARD domain containing. (196 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
GPNMBGlycoprotein nmb. (555 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
ARG1Arginase. (322 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (725 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ZP3ZP domain-containing protein. (432 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ENSCHIP00000024183Uncharacterized protein. (207 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LRRC1Leucine rich repeat containing 1. (517 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
IGF2Insulin-like growth factor II. (179 aa)
ANXA1Annexin. (346 aa)
LOC102183203Amine oxidase. (517 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (844 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
TNFRSF1BTNF receptor superfamily member 1B. (459 aa)
BTNL2Butyrophilin like 2. (522 aa)
TMEM131LTransmembrane 131 like. (1599 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CD6CD6 molecule. (672 aa)
IRF1Interferon regulatory factor. (322 aa)
IDO1Uncharacterized protein. (410 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
LOC108638256Galectin. (243 aa)
LOC108633234Phospholipase A(2). (148 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (270 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
LOC102168673Phospholipase A(2). (148 aa)
SCRIBScribble planar cell polarity protein. (1582 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
CCDC88BCoiled-coil domain containing 88B. (1455 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (713 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
IL20RBInterleukin 20 receptor subunit beta. (305 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
LOC102187672Galectin. (185 aa)
CCL19C-C motif chemokine. (102 aa)
LGALS7Galectin. (139 aa)
RASAL3RAS protein activator like 3. (1013 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
LOC106503912Galectin. (116 aa)
CD274CD274 molecule. (289 aa)
ARG2Arginase. (354 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
TNFRSF13CTNF receptor superfamily member 13C. (177 aa)
BMI1RING-type domain-containing protein. (437 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
RIPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (243 aa)
PLA2G2FPhospholipase A(2). (196 aa)
CRTAMCytotoxic and regulatory T cell molecule. (414 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (711 aa)
CD86Ig-like domain-containing protein. (289 aa)
ENSCHIP00000015226KH type-2 domain-containing protein. (204 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
TSPAN32Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (411 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (714 aa)
IL27RAInterleukin 27 receptor subunit alpha. (655 aa)
BIDUncharacterized protein. (244 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (795 aa)
FOXP3Forkhead box P3. (463 aa)
IL4I1Interleukin 4 induced 1. (582 aa)
PAWRPro-apoptotic WT1 regulator. (345 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
VSIG4V-set and immunoglobulin domain containing 4. (352 aa)
ITCHE3 ubiquitin-protein ligase. (874 aa)
NCK1Cytoplasmic protein. (377 aa)
CD3ECD3e molecule. (194 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
TNFSF18TNF superfamily member 18. (194 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LGALS3Galectin. (260 aa)
LOC102189615Galectin. (186 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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