(61 nodes) Negative regulation of T cell proliferation network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAD1L1	Mitotic arrest deficient 1 like 1. (725 aa)
	FOXP3	Forkhead box P3. (463 aa)
	TSPAN32	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (411 aa)
	CD86	Ig-like domain-containing protein. (289 aa)
	CRTAM	Cytotoxic and regulatory T cell molecule. (414 aa)
	PLA2G2F	Phospholipase A(2). (196 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (280 aa)
	ARG2	Arginase. (354 aa)
	CD274	CD274 molecule. (289 aa)
	LOC106503912	Galectin. (116 aa)
	LGALS7	Galectin. (139 aa)
	LOC102187672	Galectin. (185 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (305 aa)
	MARCHF7	Membrane associated ring-CH-type finger 7. (713 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (901 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (296 aa)
	CBLB	Cbl proto-oncogene B. (983 aa)
	PAWR	Pro-apoptotic WT1 regulator. (345 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	VSIG4	V-set and immunoglobulin domain containing 4. (352 aa)
	ITCH	E3 ubiquitin-protein ligase. (874 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	ENSCHIP00000006184	Uncharacterized protein. (96 aa)
	ENSCHIP00000005724	Uncharacterized protein. (62 aa)
	LOC102184087	Galectin. (342 aa)
	CD80	CD80 molecule. (302 aa)
	VSIR	V-set immunoregulatory receptor. (312 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	LOC102189615	Galectin. (186 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
	LRRC32	Leucine rich repeat containing 32. (710 aa)
	LOC102180339	Galectin-7. (139 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	GLMN	Glomulin, FKBP associated protein. (592 aa)
	GPNMB	Glycoprotein nmb. (555 aa)
	ARG1	Arginase. (322 aa)
	IL4I1	Interleukin 4 induced 1. (582 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	LRRC1	Leucine rich repeat containing 1. (517 aa)
	LOC102183203	Amine oxidase. (517 aa)
	TMEM131L	Transmembrane 131 like. (1599 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	IDO1	Uncharacterized protein. (410 aa)
	LOC108638256	Galectin. (243 aa)
	LOC108633234	Phospholipase A(2). (148 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (270 aa)
	LOC102168673	Phospholipase A(2). (148 aa)
	CLEC4G	C-type lectin domain family 4 member G. (291 aa)
	NDFIP1	Nedd4 family interacting protein 1. (221 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (539 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1250 aa)
	ENSCHIP00000031738	Galectin. (224 aa)
	CEBPB	CCAAT/enhancer-binding protein. (307 aa)
	SCRIB	Scribble planar cell polarity protein. (1582 aa)
	TNFRSF21	TNF receptor superfamily member 21. (652 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG1	ARG2	ENSCHIP00000025258	ENSCHIP00000017404	Arginase.	Arginase.	0.910
ARG1	CASP3	ENSCHIP00000025258	ENSCHIP00000011490	Arginase.	Caspase 3; Belongs to the peptidase C14A family.	0.569
ARG1	CD274	ENSCHIP00000025258	ENSCHIP00000017515	Arginase.	CD274 molecule.	0.526
ARG1	CD80	ENSCHIP00000025258	ENSCHIP00000005477	Arginase.	CD80 molecule.	0.738
ARG1	CD86	ENSCHIP00000025258	ENSCHIP00000015363	Arginase.	Ig-like domain-containing protein.	0.902
ARG1	FOXP3	ENSCHIP00000025258	ENSCHIP00000012575	Arginase.	Forkhead box P3.	0.716
ARG1	IDO1	ENSCHIP00000025258	ENSCHIP00000021645	Arginase.	Uncharacterized protein.	0.692
ARG1	TGFB1	ENSCHIP00000025258	ENSCHIP00000008885	Arginase.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.682
ARG2	ARG1	ENSCHIP00000017404	ENSCHIP00000025258	Arginase.	Arginase.	0.910
ARG2	CD274	ENSCHIP00000017404	ENSCHIP00000017515	Arginase.	CD274 molecule.	0.456
ARG2	CD80	ENSCHIP00000017404	ENSCHIP00000005477	Arginase.	CD80 molecule.	0.534
ARG2	CD86	ENSCHIP00000017404	ENSCHIP00000015363	Arginase.	Ig-like domain-containing protein.	0.528
ARG2	FOXP3	ENSCHIP00000017404	ENSCHIP00000012575	Arginase.	Forkhead box P3.	0.456
ARG2	IDO1	ENSCHIP00000017404	ENSCHIP00000021645	Arginase.	Uncharacterized protein.	0.589
BMP4	CASP3	ENSCHIP00000023678	ENSCHIP00000011490	Bone morphogenetic protein 4.	Caspase 3; Belongs to the peptidase C14A family.	0.488
BMP4	IHH	ENSCHIP00000023678	ENSCHIP00000016239	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.790
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	TGFB1	ENSCHIP00000023678	ENSCHIP00000008885	Bone morphogenetic protein 4.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.495
BMP4	TWSG1	ENSCHIP00000023678	ENSCHIP00000032482	Bone morphogenetic protein 4.	Twisted gastrulation BMP signaling modulator 1.	0.586
CASP3	ARG1	ENSCHIP00000011490	ENSCHIP00000025258	Caspase 3; Belongs to the peptidase C14A family.	Arginase.	0.569