STRINGSTRING
PTPN22 PTPN22 HCLS1 HCLS1 JUP JUP TARDBP TARDBP ECT2 ECT2 PSEN1 PSEN1 HDAC3 HDAC3 SHH SHH SMO SMO EPM2A EPM2A PKIG PKIG CHP1 CHP1 DMAP1 DMAP1 ZC3H12A ZC3H12A PIK3R1 PIK3R1 BMP4 BMP4 UBR5 UBR5 CHP2 CHP2 EFCAB7 EFCAB7 LEP LEP BAG3 BAG3 CDH1 CDH1 IPO5 IPO5 PRKD1 PRKD1 FERMT1 FERMT1 IFNG IFNG APOD APOD RBM22 RBM22 ENSCHIP00000014358 ENSCHIP00000014358 GLI3 GLI3 PRKCD PRKCD TPR TPR ZPR1 ZPR1 UFM1 UFM1 TRIM28 TRIM28 CABP1 CABP1 TGFB1 TGFB1 FLNA FLNA NF1 NF1 RAB23 RAB23 HYAL2 HYAL2 PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN22Protein tyrosine phosphatase non-receptor type 22. (795 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (471 aa)
JUPJunction plakoglobin. (745 aa)
TARDBPTAR DNA binding protein. (414 aa)
ECT2Epithelial cell transforming 2. (913 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (468 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2801 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
BAG3BCL2 associated athanogene 3. (576 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (903 aa)
IPO5Importin 5. (1097 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
FERMT1Fermitin family member 1. (679 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
APODApolipoprotein D. (213 aa)
RBM22RNA binding motif protein 22. (420 aa)
ENSCHIP00000014358Uncharacterized protein. (90 aa)
GLI3GLI family zinc finger 3. (1614 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
TPRTranslocated promoter region, nuclear basket protein. (2436 aa)
ZPR1ZPR1 zinc finger. (459 aa)
UFM1Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. (85 aa)
TRIM28Tripartite motif containing 28. (837 aa)
CABP1Calcium binding protein 1. (421 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FLNAFilamin A. (2647 aa)
NF1Neurofibromin 1. (2848 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
HYAL2Hyaluronidase. (476 aa)
PIK3R2Uncharacterized protein. (724 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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