(89 nodes) Melanosome network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC1A5	Amino acid transporter. (530 aa)
	CAPG	Capping actin protein, gelsolin like. (349 aa)
	CD63	Tetraspanin. (237 aa)
	HPS4	Uncharacterized protein. (436 aa)
	ENSCHIP00000025598	Uncharacterized protein. (240 aa)
	TMED10	Transmembrane p24 trafficking protein 10. (219 aa)
	DTNBP1	Dystrobrevin binding protein 1. (297 aa)
	YWHAE	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa)
	SND1	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	ATP6V1G2	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	MREG	Melanoregulin. (214 aa)
	MFSD12	Major facilitator superfamily domain containing 12. (483 aa)
	ENSCHIP00000029515	Uncharacterized protein. (96 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	PMEL	Premelanosome protein. (647 aa)
	HSPA5	Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family. (655 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
	ENSCHIP00000007454	Uncharacterized protein. (116 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	MMP14	ZnMc domain-containing protein. (584 aa)
	ENSCHIP00000009480	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	ENSCHIP00000009938	Annexin. (100 aa)
	SGSM2	Small G protein signaling modulator 2. (991 aa)
	RAB5C	Uncharacterized protein. (216 aa)
	RAB1A	Uncharacterized protein. (206 aa)
	CCT4	T-complex protein 1 subunit delta. (541 aa)
	RAB32	RAB32, member RAS oncogene family. (225 aa)
	MLANA	Melan-A. (118 aa)
	ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group). (848 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	ENSCHIP00000015518	Uncharacterized protein; Belongs to the heat shock protein 70 family. (520 aa)
	RAB17	RAB17, member RAS oncogene family. (213 aa)
	ENSCHIP00000015970	Uncharacterized protein. (360 aa)
	ANXA6	Annexin. (689 aa)
	ENSCHIP00000016214	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (289 aa)
	GPR143	G protein-coupled receptor 143. (413 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	SLC1A4	Solute carrier family 1 member 4. (527 aa)
	ENSCHIP00000030683	Uncharacterized protein. (66 aa)
	OCA2	OCA2 melanosomal transmembrane protein. (838 aa)
	ENSCHIP00000030705	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (206 aa)
	RAB5A	Uncharacterized protein. (215 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (335 aa)
	CALU	Calumenin. (315 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	TH	Tyrosine hydroxylase. (516 aa)
	TYRP1	Uncharacterized protein. (537 aa)
	SERPINF1	Serpin family F member 1; Belongs to the serpin family. (416 aa)
	TMEM33	Transmembrane protein 33. (247 aa)
	P4HB	Protein disulfide-isomerase. (565 aa)
	DNAJC5	J domain-containing protein. (198 aa)
	AHCY	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (432 aa)
	TFRC	Transferrin receptor. (790 aa)
	ATP1B3	ATPase Na+/K+ transporting subunit beta 3. (279 aa)
	GGH	Folate gamma-glutamyl hydrolase. (318 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (836 aa)
	ENSCHIP00000005548	Uncharacterized protein. (126 aa)
	DCT	Dopachrome tautomerase. (517 aa)
	PDIA6	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (440 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	CNP	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
	ENSCHIP00000003201	J domain-containing protein. (179 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (412 aa)
	TYR	Tyrosinase. (530 aa)
	LOC108633809	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	RAB7A	Uncharacterized protein. (207 aa)
	LAMP1	Lysosomal associated membrane protein 1. (409 aa)
	ANXA11	Annexin. (503 aa)
	GCHFR	GTP cyclohydrolase I feedback regulator. (85 aa)
	ANKRD27	Ankyrin repeat domain 27. (1053 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
	CTNS	Cystinosin, lysosomal cystine transporter. (367 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	ENSCHIP00000020780	Uncharacterized protein. (248 aa)
	ENSCHIP00000020968	Tetraspanin. (237 aa)
	PPIB	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	PDIA4	Protein disulfide-isomerase A4. (644 aa)
	LOC102170672	T-complex protein 1 subunit delta. (529 aa)
	MYRIP	Myosin VIIA and Rab interacting protein. (854 aa)
	MYO5A	Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1896 aa)
	ENSCHIP00000023252	Uncharacterized protein. (130 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB6	GPR143	ENSCHIP00000013993	ENSCHIP00000016905	ATP binding cassette subfamily B member 6 (Langereis blood group).	G protein-coupled receptor 143.	0.452
AHCY	HSPA8	ENSCHIP00000033026	ENSCHIP00000017002	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.479
AHCY	YWHAE	ENSCHIP00000033026	ENSCHIP00000027169	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.472
ANKRD27	ENSCHIP00000030683	ENSCHIP00000017762	ENSCHIP00000030683	Ankyrin repeat domain 27.	Uncharacterized protein.	0.570
ANKRD27	RAB17	ENSCHIP00000017762	ENSCHIP00000015571	Ankyrin repeat domain 27.	RAB17, member RAS oncogene family.	0.570
ANKRD27	RAB32	ENSCHIP00000017762	ENSCHIP00000012743	Ankyrin repeat domain 27.	RAB32, member RAS oncogene family.	0.839
ANKRD27	RAB38	ENSCHIP00000017762	ENSCHIP00000028960	Ankyrin repeat domain 27.	RAB38, member RAS oncogene family.	0.689
ANKRD27	RAB5A	ENSCHIP00000017762	ENSCHIP00000030805	Ankyrin repeat domain 27.	Uncharacterized protein.	0.570
ANKRD27	RAB5C	ENSCHIP00000017762	ENSCHIP00000010444	Ankyrin repeat domain 27.	Uncharacterized protein.	0.570
ANXA11	CD63	ENSCHIP00000000173	ENSCHIP00000023741	Annexin.	Tetraspanin.	0.753
ANXA6	CD63	ENSCHIP00000016041	ENSCHIP00000023741	Annexin.	Tetraspanin.	0.742
ANXA6	FLOT1	ENSCHIP00000016041	ENSCHIP00000027785	Annexin.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.406
ANXA6	LAMP1	ENSCHIP00000016041	ENSCHIP00000000387	Annexin.	Lysosomal associated membrane protein 1.	0.471
ATP1A1	ATP1B3	ENSCHIP00000017839	ENSCHIP00000033595	Sodium/potassium-transporting ATPase subunit alpha.	ATPase Na+/K+ transporting subunit beta 3.	0.926
ATP1A1	ENSCHIP00000020780	ENSCHIP00000017839	ENSCHIP00000020780	Sodium/potassium-transporting ATPase subunit alpha.	Uncharacterized protein.	0.709
ATP1A1	ENSCHIP00000025598	ENSCHIP00000017839	ENSCHIP00000025598	Sodium/potassium-transporting ATPase subunit alpha.	Uncharacterized protein.	0.709
ATP1A1	LOC108633809	ENSCHIP00000017839	ENSCHIP00000001846	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.988
ATP1A1	RAB7A	ENSCHIP00000017839	ENSCHIP00000001040	Sodium/potassium-transporting ATPase subunit alpha.	Uncharacterized protein.	0.436
ATP1B3	ATP1A1	ENSCHIP00000033595	ENSCHIP00000017839	ATPase Na+/K+ transporting subunit beta 3.	Sodium/potassium-transporting ATPase subunit alpha.	0.926
ATP6V0A1	ATP6V1B2	ENSCHIP00000028440	ENSCHIP00000016613	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.990