STRINGSTRING
IL18 IL18 ENSCHIP00000022555 ENSCHIP00000022555 LOC106502311 LOC106502311 ENSCHIP00000021944 ENSCHIP00000021944 OSM OSM IL4 IL4 IGF1 IGF1 HES1 HES1 CLCF1 CLCF1 IL6R IL6R TNFRSF1A TNFRSF1A IL31RA IL31RA LIF LIF CRLF1 CRLF1 CTF1 CTF1 PARP9 PARP9 IFNG IFNG IL12B IL12B TNFRSF18 TNFRSF18 HPX HPX FGFR3 FGFR3 IL6ST IL6ST FYN FYN PIBF1 PIBF1 CNTF CNTF IL23A IL23A TNFSF18 TNFSF18 ARL2BP ARL2BP CSF2 CSF2 CSF1R CSF1R HCLS1 HCLS1 ERBB4 ERBB4 EPO EPO IL2 IL2 CD40 CD40 IL21 IL21 IL12A IL12A ISL1 ISL1 LYN LYN KIT KIT HES5 HES5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ENSCHIP00000022555ARL2_Bind_BART domain-containing protein. (152 aa)
LOC106502311Uncharacterized protein. (148 aa)
ENSCHIP00000021944ARL2_Bind_BART domain-containing protein. (139 aa)
OSMOncostatin M. (239 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CLCF1Cardiotrophin like cytokine factor 1. (220 aa)
IL6RInterleukin 6 receptor. (441 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
IL31RAInterleukin 31 receptor A. (714 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CRLF1Cytokine receptor like factor 1. (447 aa)
CTF1Cardiotrophin 1. (202 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
TNFRSF18Uncharacterized protein. (243 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa)
FGFR3Receptor protein-tyrosine kinase. (710 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
FYNTyrosine-protein kinase. (537 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
CNTFCiliary neurotrophic factor. (199 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
TNFSF18TNF superfamily member 18. (194 aa)
ARL2BPARL2_Bind_BART domain-containing protein. (146 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (471 aa)
ERBB4Protein kinase domain-containing protein. (462 aa)
EPOErythropoietin. (208 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
CD40CD40 molecule. (280 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (157 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
ISL1ISL LIM homeobox 1. (349 aa)
LYNTyrosine-protein kinase. (512 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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