STRINGSTRING
TRIM68 TRIM68 TFRC TFRC UBE2V1 UBE2V1 NKIRAS2 NKIRAS2 ROR1 ROR1 TRIML2 TRIML2 TAB3 TAB3 GJA1 GJA1 IFIT5 IFIT5 CCDC22 CCDC22 ENSCHIP00000002604 ENSCHIP00000002604 TRAF2 TRAF2 EDA2R EDA2R S100A13 S100A13 DAB2IP DAB2IP RHOH RHOH CLEC6A CLEC6A ENSCHIP00000003779 ENSCHIP00000003779 TREM2 TREM2 ENSCHIP00000003952 ENSCHIP00000003952 FADD FADD MID2-2 MID2-2 TNF TNF NUP62CL NUP62CL LOC102176799 LOC102176799 FYN FYN ENSCHIP00000005055 ENSCHIP00000005055 CLEC7A CLEC7A RIOK3 RIOK3 TANK TANK TRIM27 TRIM27 STAT1 STAT1 TRIM32 TRIM32 CD4 CD4 UNC5CL UNC5CL MAPKBP1 MAPKBP1 ENSCHIP00000007203 ENSCHIP00000007203 TRIM13 TRIM13 EDA EDA SIRT1 SIRT1 TIFA TIFA DDX1 DDX1 CLEC4D CLEC4D BCL10 BCL10 LOC102188481 LOC102188481 MAP3K7 MAP3K7 NUP62 NUP62 IKBKE IKBKE TRIM8 TRIM8 IRAK1 IRAK1 LOC102176375 LOC102176375 TRIM25 TRIM25 TNFRSF1A TNFRSF1A S100A12 S100A12 PPM1M PPM1M CASP1 CASP1 INAVA INAVA ENSCHIP00000011371 ENSCHIP00000011371 MAP3K3 MAP3K3 CARD9 CARD9 TRIM59 TRIM59 TNIP2 TNIP2 RHOA RHOA LURAP1 LURAP1 LITAF LITAF ESR1 ESR1 ENSCHIP00000012298 ENSCHIP00000012298 CD74 CD74 IKBKB IKBKB TNIP3 TNIP3 AKAP13 AKAP13 ENSCHIP00000012897 ENSCHIP00000012897 TNFSF11 TNFSF11 LURAP1L LURAP1L ENSCHIP00000013894 ENSCHIP00000013894 RELA RELA TRIM6 TRIM6 PDPK1 PDPK1 ATP2C1 ATP2C1 LOC102169889 LOC102169889 ENSCHIP00000015005 ENSCHIP00000015005 TLR3 TLR3 TRAF6 TRAF6 HSPB1 HSPB1 WNT5A WNT5A PARK2 PARK2 CFLAR CFLAR NLRP12 NLRP12 UFL1 UFL1 TRAF5 TRAF5 TNFSF10 TNFSF10 OTUD7A OTUD7A BTRC BTRC LTF LTF PRKCB PRKCB CHUK CHUK MAP3K14 MAP3K14 PLCG2 PLCG2 NR1D1 NR1D1 DHX36 DHX36 MYD88 MYD88 PRKD1 PRKD1 NLRX1 NLRX1 ENSCHIP00000018249 ENSCHIP00000018249 OPTN OPTN IRAK4 IRAK4 PRKCE PRKCE CCL19 CCL19 ANKRD17 ANKRD17 TLR4 TLR4 RIPK2 RIPK2 TLE1 TLE1 TRIM38 TRIM38 CASP8 CASP8 NOD1 NOD1 TRAF1 TRAF1 TRAF3IP2 TRAF3IP2 REL REL MTDH MTDH ALPK1 ALPK1 ENSCHIP00000022451 ENSCHIP00000022451 HDAC1 HDAC1 ENSCHIP00000022790 ENSCHIP00000022790 OTUD7B OTUD7B TRIM39 TRIM39 LOC102170446 LOC102170446 PIDD1 PIDD1 MID2 MID2 ENSCHIP00000023383 ENSCHIP00000023383 CARD11 CARD11 NR1H4 NR1H4 TAB2 TAB2 LPAR1 LPAR1 TERF2IP TERF2IP C18orf32 C18orf32 PPM1N PPM1N TNFAIP3 TNFAIP3 S100B S100B LOC102170165 LOC102170165 ABL1 ABL1 TNFRSF19 TNFRSF19 ZC3H12A ZC3H12A PPM1B PPM1B PELI1 PELI1 TMEM101 TMEM101 TRIM62 TRIM62 LOC102173185 LOC102173185 NLRC3 NLRC3 F2R F2R GAPDH GAPDH PPM1A PPM1A FASLG FASLG TBK1 TBK1 NFKBIB NFKBIB SQSTM1 SQSTM1 BTNL9 BTNL9 LTBR LTBR PYCARD PYCARD LOC108638216 LOC108638216 CAPN3 CAPN3 IKBKG IKBKG SPHK2 SPHK2 CD40 CD40 EDAR EDAR IL1B IL1B SHARPIN SHARPIN TRIM21 TRIM21 NOD2 NOD2 ZMYND11 ZMYND11 TRADD TRADD TNIP1 TNIP1 ENSCHIP00000030535 ENSCHIP00000030535 S100A4 S100A4 CTNNB1 CTNNB1 LOC102172606 LOC102172606 PINK1 PINK1 CCL21 CCL21 TRIML1 TRIML1 RORA RORA WDR83 WDR83 USP10 USP10 TIRAP TIRAP AJUBA AJUBA ENSCHIP00000031771 ENSCHIP00000031771 HTR2B HTR2B DHX15 DHX15 F2RL1 F2RL1 ASH1L ASH1L CPNE1 CPNE1 TRAF3 TRAF3 RBCK1 RBCK1 RIPK1 RIPK1 ADIPOQ ADIPOQ CACTIN CACTIN RNF31 RNF31 DDX21 DDX21 DDX50 DDX50 JMJD8 JMJD8 TMEM106A TMEM106A ENSCHIP00000000923 ENSCHIP00000000923
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM68Tripartite motif containing 68. (494 aa)
TFRCTransferrin receptor. (790 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (147 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (932 aa)
TRIML2Tripartite motif family like 2. (438 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (481 aa)
CCDC22Coiled-coil domain containing 22. (626 aa)
ENSCHIP00000002604Uncharacterized protein. (697 aa)
TRAF2TNF receptor-associated factor. (497 aa)
EDA2REctodysplasin A2 receptor. (299 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
DAB2IPDAB2 interacting protein. (1198 aa)
RHOHRas homolog family member H. (191 aa)
CLEC6AC-type lectin domain containing 6A. (206 aa)
ENSCHIP00000003779Uncharacterized protein. (330 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ENSCHIP00000003952B30.2/SPRY domain-containing protein. (197 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
MID2-2RING-type domain-containing protein. (240 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
NUP62CLNsp1_C domain-containing protein. (304 aa)
LOC102176799Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSCHIP00000005055Uncharacterized protein. (162 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
TANKTBD domain-containing protein. (422 aa)
TRIM27Tripartite motif containing 27. (513 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
TRIM32Tripartite motif containing 32. (695 aa)
CD4CD4 molecule. (455 aa)
UNC5CLUnc-5 family C-terminal like. (518 aa)
MAPKBP1Mitogen-activated protein kinase binding protein 1. (1497 aa)
ENSCHIP00000007203Uncharacterized protein. (163 aa)
TRIM13Tripartite motif containing 13. (407 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (257 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
DDX1DEAD-box helicase 1. (740 aa)
CLEC4DC-type lectin domain family 4 member D. (212 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
LOC102188481Uncharacterized protein. (379 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NUP62Nucleoporin 62. (523 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (712 aa)
TRIM8Tripartite motif containing 8. (551 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (718 aa)
LOC102176375Uncharacterized protein. (162 aa)
TRIM25Tripartite motif containing 25. (633 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
PPM1MPPM-type phosphatase domain-containing protein. (461 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (411 aa)
INAVAInnate immunity activator. (644 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (620 aa)
CARD9Caspase recruitment domain family member 9. (519 aa)
TRIM59Uncharacterized protein. (404 aa)
TNIP2TNFAIP3 interacting protein 2. (429 aa)
RHOARas-like protein family member A. (193 aa)
LURAP1Leucine rich adaptor protein 1. (239 aa)
LITAFLipopolysaccharide induced TNF factor. (161 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
ENSCHIP00000012298Uncharacterized protein. (736 aa)
CD74CD74 molecule. (261 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TNIP3TNFAIP3 interacting protein 3. (376 aa)
AKAP13A-kinase anchoring protein 13. (2818 aa)
ENSCHIP00000012897PPM-type phosphatase domain-containing protein. (365 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
LURAP1LLeucine rich adaptor protein 1 like. (226 aa)
ENSCHIP00000013894Uncharacterized protein. (463 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
TRIM6Tripartite motif containing 6. (487 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (953 aa)
LOC102169889TRIM5 alpha. (509 aa)
ENSCHIP00000015005Uncharacterized protein. (908 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PARK2Ubiquitin-like domain-containing protein. (293 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (484 aa)
NLRP12NLR family pyrin domain containing 12. (1048 aa)
UFL1UFM1 specific ligase 1. (792 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
OTUD7AOTU deubiquitinase 7A. (939 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (754 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (616 aa)
DHX36DEAH-box helicase 36. (1010 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
NLRX1NLR family member X1. (973 aa)
ENSCHIP00000018249Uncharacterized protein. (148 aa)
OPTNOptineurin. (573 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
CCL19C-C motif chemokine. (102 aa)
ANKRD17Ankyrin repeat domain 17. (2604 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
TRIM38Tripartite motif containing 38. (460 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (954 aa)
TRAF1TNF receptor-associated factor. (410 aa)
TRAF3IP2TRAF3 interacting protein 2. (572 aa)
RELREL proto-oncogene, NF-kB subunit. (591 aa)
MTDHMetadherin. (583 aa)
ALPK1Alpha kinase 1. (1241 aa)
ENSCHIP00000022451TBD domain-containing protein. (430 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
ENSCHIP00000022790UCH domain-containing protein. (675 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
TRIM39Tripartite motif containing 39. (488 aa)
LOC102170446Uncharacterized protein. (489 aa)
PIDD1P53-induced death domain protein 1. (913 aa)
MID2Midline 2. (463 aa)
ENSCHIP00000023383RBR-type E3 ubiquitin transferase. (84 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
TERF2IPUncharacterized protein. (400 aa)
C18orf32Chromosome 18 open reading frame 32. (76 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (406 aa)
TNFAIP3TNF alpha induced protein 3. (785 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
LOC102170165Uncharacterized protein. (475 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
TNFRSF19TNF receptor superfamily member 19. (424 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
PPM1BPPM-type phosphatase domain-containing protein. (484 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
TMEM101Transmembrane protein 101. (257 aa)
TRIM62Tripartite motif containing 62. (475 aa)
LOC102173185Uncharacterized protein. (509 aa)
NLRC3NLR family CARD domain containing 3. (1111 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
PPM1APPM-type phosphatase domain-containing protein. (382 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
TBK1TANK binding kinase 1. (734 aa)
NFKBIBNFKB inhibitor beta. (364 aa)
SQSTM1Sequestosome 1. (440 aa)
BTNL9Butyrophilin like 9. (538 aa)
LTBRUncharacterized protein. (428 aa)
PYCARDPYD and CARD domain containing. (196 aa)
LOC108638216Uncharacterized protein. (629 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (819 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (408 aa)
SPHK2Sphingosine kinase 2. (653 aa)
CD40CD40 molecule. (280 aa)
EDAREctodysplasin A receptor. (441 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
SHARPINSHANK associated RH domain interactor. (501 aa)
TRIM21Tripartite motif containing 21. (465 aa)
NOD2Uncharacterized protein. (982 aa)
ZMYND11Zinc finger MYND-type containing 11. (617 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
TNIP1TNFAIP3 interacting protein 1. (617 aa)
ENSCHIP00000030535zf-RING_14 domain-containing protein. (149 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC102172606Uncharacterized protein. (338 aa)
PINK1PTEN induced kinase 1. (587 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
TRIML1Tripartite motif family like 1. (474 aa)
RORAUncharacterized protein. (527 aa)
WDR83WD repeat domain 83. (315 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (798 aa)
TIRAPTIR domain containing adaptor protein. (228 aa)
AJUBAAjuba LIM protein. (571 aa)
ENSCHIP00000031771C2 domain-containing protein. (204 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
DHX15DEAH-box helicase 15. (795 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ASH1LASH1 like histone lysine methyltransferase. (2968 aa)
CPNE1Copine 1. (537 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
ADIPOQC1q domain-containing protein. (283 aa)
CACTINCactin, spliceosome C complex subunit. (708 aa)
RNF31Uncharacterized protein. (1066 aa)
DDX21Uncharacterized protein. (754 aa)
DDX50DExD-box helicase 50. (738 aa)
JMJD8Jumonji domain containing 8. (344 aa)
TMEM106ATransmembrane protein 106A. (261 aa)
ENSCHIP00000000923Uncharacterized protein. (467 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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