(37 nodes) Positive regulation of DNA binding network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	TRIM6	Tripartite motif containing 6. (487 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	TRIM28	Tripartite motif containing 28. (837 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	MMP8	Matrix metallopeptidase 8. (470 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SKI	SKI proto-oncogene. (729 aa)
	NIBAN2	Niban apoptosis regulator 2. (744 aa)
	RB1	RB transcriptional corepressor 1. (931 aa)
	POU4F1	POU domain protein. (421 aa)
	EDF1	Endothelial differentiation related factor 1. (148 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
	PARK2	Ubiquitin-like domain-containing protein. (293 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	MMP9	Uncharacterized protein. (709 aa)
	IRF4	Interferon regulatory factor 4. (450 aa)
	NME1	Nucleoside diphosphate kinase. (157 aa)
	EP300	E1A binding protein p300. (2411 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	PLAUR	Plasminogen activator, urokinase receptor. (331 aa)
	DDRGK1	DDRGK domain containing 1. (298 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa)
	ENSCHIP00000023383	RBR-type E3 ubiquitin transferase. (84 aa)
	MYOCD	Myocardin. (982 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1228 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
	PAX6	Paired box 6. (486 aa)
	GATA3	GATA binding protein 3. (467 aa)
	ENSCHIP00000030535	zf-RING_14 domain-containing protein. (149 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GTF2B	General transcription factor IIB. (316 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	EP300	ENSCHIP00000031016	ENSCHIP00000018340	Catenin beta 1.	E1A binding protein p300.	0.993
CTNNB1	GATA3	ENSCHIP00000031016	ENSCHIP00000030187	Catenin beta 1.	GATA binding protein 3.	0.435
CTNNB1	IFNG	ENSCHIP00000031016	ENSCHIP00000016152	Catenin beta 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.628
CTNNB1	IGF1	ENSCHIP00000031016	ENSCHIP00000020185	Catenin beta 1.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.700
CTNNB1	ISL1	ENSCHIP00000031016	ENSCHIP00000025978	Catenin beta 1.	ISL LIM homeobox 1.	0.443
CTNNB1	MMP9	ENSCHIP00000031016	ENSCHIP00000016938	Catenin beta 1.	Uncharacterized protein.	0.828
CTNNB1	PAX6	ENSCHIP00000031016	ENSCHIP00000027464	Catenin beta 1.	Paired box 6.	0.699
CTNNB1	SIRT2	ENSCHIP00000031016	ENSCHIP00000021508	Catenin beta 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.542
CTNNB1	TGFB1	ENSCHIP00000031016	ENSCHIP00000008885	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.753
CTNNB1	TRAF6	ENSCHIP00000031016	ENSCHIP00000015162	Catenin beta 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.431
ENSCHIP00000023383	PARK2	ENSCHIP00000023383	ENSCHIP00000015951	RBR-type E3 ubiquitin transferase.	Ubiquitin-like domain-containing protein.	0.657
ENSCHIP00000023383	PARK7	ENSCHIP00000023383	ENSCHIP00000025227	RBR-type E3 ubiquitin transferase.	Parkinsonism associated deglycase.	0.724
ENSCHIP00000030535	PARK7	ENSCHIP00000030535	ENSCHIP00000025227	zf-RING_14 domain-containing protein.	Parkinsonism associated deglycase.	0.724
EP300	CTNNB1	ENSCHIP00000018340	ENSCHIP00000031016	E1A binding protein p300.	Catenin beta 1.	0.993
EP300	GATA3	ENSCHIP00000018340	ENSCHIP00000030187	E1A binding protein p300.	GATA binding protein 3.	0.948
EP300	GTF2B	ENSCHIP00000018340	ENSCHIP00000031858	E1A binding protein p300.	General transcription factor IIB.	0.600
EP300	HIPK2	ENSCHIP00000018340	ENSCHIP00000023809	E1A binding protein p300.	Homeodomain interacting protein kinase 2.	0.538
EP300	IRF4	ENSCHIP00000018340	ENSCHIP00000017187	E1A binding protein p300.	Interferon regulatory factor 4.	0.549
EP300	MYOCD	ENSCHIP00000018340	ENSCHIP00000023758	E1A binding protein p300.	Myocardin.	0.401
EP300	PAX6	ENSCHIP00000018340	ENSCHIP00000027464	E1A binding protein p300.	Paired box 6.	0.530