39 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JMJD8	Jumonji domain containing 8. (344 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (339 aa)
	TREX1	Three prime repair exonuclease 1. (315 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	SLC4A1	Anion exchange protein. (978 aa)
	NCOR1	Nuclear receptor corepressor 1. (2447 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	DDIT4	DNA damage inducible transcript 4. (229 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (902 aa)
	SCARB2	Uncharacterized protein; Belongs to the CD36 family. (478 aa)
	INSR	Tyrosine-protein kinase receptor. (1365 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (470 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	EP300	E1A binding protein p300. (2411 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (751 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	SLC4A4	Anion exchange protein. (1125 aa)
	GPD1	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (358 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	MLXIPL	MLX interacting protein like. (854 aa)
	ENSCHIP00000023520	Uncharacterized protein; Belongs to the CD36 family. (395 aa)
	ARL2	ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
	GIT1	GIT ArfGAP 1. (738 aa)
	SLC2A6	Solute carrier family 2 member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (507 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (602 aa)
	PRXL2C	Peroxiredoxin like 2C. (228 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (565 aa)
	CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3. (714 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
	SIRT6	Sirtuin 6. (335 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (470 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	EP300	ENSCHIP00000032622	ENSCHIP00000018340	Amyloid beta precursor protein.	E1A binding protein p300.	0.426
APP	HTR2A	ENSCHIP00000032622	ENSCHIP00000016814	Amyloid beta precursor protein.	5-hydroxytryptamine receptor 2A.	0.405
APP	INS	ENSCHIP00000032622	ENSCHIP00000007610	Amyloid beta precursor protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.593
APP	PSEN1	ENSCHIP00000032622	ENSCHIP00000030611	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.990
APP	SCARB2	ENSCHIP00000032622	ENSCHIP00000011784	Amyloid beta precursor protein.	Uncharacterized protein; Belongs to the CD36 family.	0.421
CBFA2T3	NCOR1	ENSCHIP00000029667	ENSCHIP00000005863	CBFA2/RUNX1 partner transcriptional co-repressor 3.	Nuclear receptor corepressor 1.	0.575
DDIT4	EP300	ENSCHIP00000008775	ENSCHIP00000018340	DNA damage inducible transcript 4.	E1A binding protein p300.	0.623
DDIT4	OGT	ENSCHIP00000008775	ENSCHIP00000001120	DNA damage inducible transcript 4.	O-linked N-acetylglucosamine (GlcNAc) transferase.	0.473
DDIT4	PPARA	ENSCHIP00000008775	ENSCHIP00000032439	DNA damage inducible transcript 4.	Peroxisome proliferator activated receptor alpha.	0.447
DDIT4	TP53	ENSCHIP00000008775	ENSCHIP00000030141	DNA damage inducible transcript 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.581
EP300	APP	ENSCHIP00000018340	ENSCHIP00000032622	E1A binding protein p300.	Amyloid beta precursor protein.	0.426
EP300	DDIT4	ENSCHIP00000018340	ENSCHIP00000008775	E1A binding protein p300.	DNA damage inducible transcript 4.	0.623
EP300	HDAC4	ENSCHIP00000018340	ENSCHIP00000019494	E1A binding protein p300.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.593
EP300	HIF1A	ENSCHIP00000018340	ENSCHIP00000014770	E1A binding protein p300.	Uncharacterized protein.	0.998
EP300	NCOR1	ENSCHIP00000018340	ENSCHIP00000005863	E1A binding protein p300.	Nuclear receptor corepressor 1.	0.846
EP300	OGT	ENSCHIP00000018340	ENSCHIP00000001120	E1A binding protein p300.	O-linked N-acetylglucosamine (GlcNAc) transferase.	0.574
EP300	PPARA	ENSCHIP00000018340	ENSCHIP00000032439	E1A binding protein p300.	Peroxisome proliferator activated receptor alpha.	0.846
EP300	STAT3	ENSCHIP00000018340	ENSCHIP00000022282	E1A binding protein p300.	Signal transducer and activator of transcription.	0.991
EP300	TP53	ENSCHIP00000018340	ENSCHIP00000030141	E1A binding protein p300.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
EP300	ZBTB20	ENSCHIP00000018340	ENSCHIP00000018617	E1A binding protein p300.	Zinc finger and BTB domain containing 20.	0.419