77 items (Capra hircus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (585 aa)
	GLUD1	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (561 aa)
	ME2	Malic enzyme. (584 aa)
	DDO	D-aspartate oxidase. (341 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	FH	Fumarate hydratase. (514 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	ENSCHIP00000002136	Uncharacterized protein. (103 aa)
	LOC102191395	FAD-binding PCMH-type domain-containing protein. (479 aa)
	OGDH	Oxoglutarate dehydrogenase. (1038 aa)
	NAGS	N-acetylglutamate synthase. (534 aa)
	ALDH1L1	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (899 aa)
	ENSCHIP00000004162	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (515 aa)
	GLS	Glutaminase. (673 aa)
	SDHAF3	Uncharacterized protein. (125 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (825 aa)
	GLS2	Glutaminase 2. (605 aa)
	LOC108633249	Uncharacterized protein. (103 aa)
	UROC1	Urocanate hydratase 1. (692 aa)
	FTCD	Formimidoyltransferase cyclodeaminase. (540 aa)
	ENSCHIP00000008524	Uncharacterized protein. (86 aa)
	ACSF3	Acyl-CoA synthetase family member 3. (586 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (618 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
	OAT	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	ME3	Malic enzyme. (604 aa)
	GOT1L1	Glutamic-oxaloacetic transaminase 1 like 1. (404 aa)
	LOC102169668	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (188 aa)
	MDH1	Malate dehydrogenase. (334 aa)
	DLST	Dihydrolipoamide S-succinyltransferase. (468 aa)
	ASL	Uncharacterized protein. (473 aa)
	DHFR	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (576 aa)
	ACOT8	Acyl-CoA thioesterase 8. (335 aa)
	ASS1	Argininosuccinate synthase 1. (426 aa)
	GAD1	Glutamate decarboxylase 1. (594 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
	ADHFE1	Fe-ADH domain-containing protein. (443 aa)
	PRODH2	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (461 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (447 aa)
	HOGA1	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa)
	HAL	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
	ENSCHIP00000020279	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (353 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (697 aa)
	ADSS2	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	ALDH1L2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	ENSCHIP00000021405	DHFR domain-containing protein. (156 aa)
	ENSCHIP00000021763	FAD-binding PCMH-type domain-containing protein. (295 aa)
	KYAT3	Kynurenine aminotransferase 3. (476 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (295 aa)
	ALDH5A1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (510 aa)
	GAD2	Glutamate decarboxylase 2. (585 aa)
	FOLR1	Folate_rec domain-containing protein. (251 aa)
	LOC102182692	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (601 aa)
	FTCDNL1	Formiminotransferase cyclodeaminase N-terminal like. (202 aa)
	MDH1B	Malate dehydrogenase 1B. (450 aa)
	ENSCHIP00000026235	Ldh_1_C domain-containing protein. (277 aa)
	ME1	Malic enzyme. (571 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
	AMDHD1	Amidohydrolase domain containing 1. (426 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	AADAT	Aminotran_1_2 domain-containing protein. (425 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	NIT2	Nitrilase family member 2. (283 aa)
	C10orf62	Chromosome 10 open reading frame 62. (225 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa)
	ENSCHIP00000032327	Uncharacterized protein. (105 aa)
	LOC108636344	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (430 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (975 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (523 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADAT	HAAO	ENSCHIP00000030168	ENSCHIP00000012374	Aminotran_1_2 domain-containing protein.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	0.731
AADAT	KMO	ENSCHIP00000030168	ENSCHIP00000019044	Aminotran_1_2 domain-containing protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.974
AADAT	KYAT3	ENSCHIP00000030168	ENSCHIP00000021831	Aminotran_1_2 domain-containing protein.	Kynurenine aminotransferase 3.	0.938
AADAT	KYNU	ENSCHIP00000030168	ENSCHIP00000031339	Aminotran_1_2 domain-containing protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.947
AADAT	QPRT	ENSCHIP00000030168	ENSCHIP00000022525	Aminotran_1_2 domain-containing protein.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.515
ACLY	ALDH18A1	ENSCHIP00000027213	ENSCHIP00000005149	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.470
ACLY	ALDH1L1	ENSCHIP00000027213	ENSCHIP00000003987	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.436
ACLY	ALDH1L2	ENSCHIP00000027213	ENSCHIP00000021223	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.487
ACLY	ALDH4A1	ENSCHIP00000027213	ENSCHIP00000015660	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.561
ACLY	ALDH5A1	ENSCHIP00000027213	ENSCHIP00000022698	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.901
ACLY	ASL	ENSCHIP00000027213	ENSCHIP00000014908	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.846
ACLY	DDO	ENSCHIP00000027213	ENSCHIP00000001123	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	D-aspartate oxidase.	0.808
ACLY	DLST	ENSCHIP00000027213	ENSCHIP00000014842	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dihydrolipoamide S-succinyltransferase.	0.795
ACLY	ENSCHIP00000020279	ENSCHIP00000027213	ENSCHIP00000020279	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.690
ACLY	ENSCHIP00000026235	ENSCHIP00000027213	ENSCHIP00000026235	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Ldh_1_C domain-containing protein.	0.533
ACLY	FH	ENSCHIP00000027213	ENSCHIP00000001713	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fumarate hydratase.	0.739
ACLY	GLUD1	ENSCHIP00000027213	ENSCHIP00000000388	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.884
ACLY	GOT1	ENSCHIP00000027213	ENSCHIP00000029101	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.879
ACLY	GOT1L1	ENSCHIP00000027213	ENSCHIP00000013967	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Glutamic-oxaloacetic transaminase 1 like 1.	0.844
ACLY	GOT2	ENSCHIP00000027213	ENSCHIP00000010968	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.884