node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBS2 | BBS4 | ENSCHIP00000022891 | ENSCHIP00000013678 | Bardet-Biedl syndrome 2 protein homolog. | Bardet-Biedl syndrome 4. | 0.999 |
BBS4 | BBS2 | ENSCHIP00000013678 | ENSCHIP00000022891 | Bardet-Biedl syndrome 4. | Bardet-Biedl syndrome 2 protein homolog. | 0.999 |
CCND1 | LEP | ENSCHIP00000006815 | ENSCHIP00000021235 | Cyclin D1; Belongs to the cyclin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.737 |
CCND1 | SIRT1 | ENSCHIP00000006815 | ENSCHIP00000007571 | Cyclin D1; Belongs to the cyclin family. | Deacetylase sirtuin-type domain-containing protein. | 0.708 |
CCND1 | STAT3 | ENSCHIP00000006815 | ENSCHIP00000022282 | Cyclin D1; Belongs to the cyclin family. | Signal transducer and activator of transcription. | 0.932 |
LEP | CCND1 | ENSCHIP00000021235 | ENSCHIP00000006815 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Cyclin D1; Belongs to the cyclin family. | 0.737 |
LEP | LEPR | ENSCHIP00000021235 | ENSCHIP00000027406 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Leptin receptor. | 0.999 |
LEP | SIRT1 | ENSCHIP00000021235 | ENSCHIP00000007571 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Deacetylase sirtuin-type domain-containing protein. | 0.660 |
LEP | STAT3 | ENSCHIP00000021235 | ENSCHIP00000022282 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Signal transducer and activator of transcription. | 0.970 |
LEPR | LEP | ENSCHIP00000027406 | ENSCHIP00000021235 | Leptin receptor. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.999 |
LEPR | STAT3 | ENSCHIP00000027406 | ENSCHIP00000022282 | Leptin receptor. | Signal transducer and activator of transcription. | 0.818 |
SIRT1 | CCND1 | ENSCHIP00000007571 | ENSCHIP00000006815 | Deacetylase sirtuin-type domain-containing protein. | Cyclin D1; Belongs to the cyclin family. | 0.708 |
SIRT1 | LEP | ENSCHIP00000007571 | ENSCHIP00000021235 | Deacetylase sirtuin-type domain-containing protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.660 |
SIRT1 | STAT3 | ENSCHIP00000007571 | ENSCHIP00000022282 | Deacetylase sirtuin-type domain-containing protein. | Signal transducer and activator of transcription. | 0.686 |
STAT3 | CCND1 | ENSCHIP00000022282 | ENSCHIP00000006815 | Signal transducer and activator of transcription. | Cyclin D1; Belongs to the cyclin family. | 0.932 |
STAT3 | LEP | ENSCHIP00000022282 | ENSCHIP00000021235 | Signal transducer and activator of transcription. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.970 |
STAT3 | LEPR | ENSCHIP00000022282 | ENSCHIP00000027406 | Signal transducer and activator of transcription. | Leptin receptor. | 0.818 |
STAT3 | SIRT1 | ENSCHIP00000022282 | ENSCHIP00000007571 | Signal transducer and activator of transcription. | Deacetylase sirtuin-type domain-containing protein. | 0.686 |