STRINGSTRING
RNF8 RNF8 ATAD5 ATAD5 DEF6 DEF6 FOXP3 FOXP3 MSH6 MSH6 EXO1 EXO1 AICDA AICDA NBN NBN BATF BATF UNG UNG EXOSC6 EXOSC6 SWAP70 SWAP70 LIG4 LIG4 ENSCHIP00000000047 ENSCHIP00000000047 BCL6 BCL6 KIAA1841 KIAA1841 STAT6 STAT6 ERCC1 ERCC1 CCR6 CCR6 RNF168 RNF168 MSH2 MSH2 EXOSC3 EXOSC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
DEF6DEF6 guanine nucleotide exchange factor. (632 aa)
FOXP3Forkhead box P3. (463 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
EXO1Exonuclease 1. (835 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa)
EXOSC6Exosome component 6. (272 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
LIG4DNA ligase. (911 aa)
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
BCL6BCL6 transcription repressor. (706 aa)
KIAA1841KIAA1841. (704 aa)
STAT6Signal transducer and activator of transcription. (841 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
EXOSC3Exosome component 3. (275 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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