node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT2 | DDAH1 | ENSCHIP00000025513 | ENSCHIP00000029459 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dimethylarginine dimethylaminohydrolase 1. | 0.868 |
AGXT2 | DDAH2 | ENSCHIP00000025513 | ENSCHIP00000033039 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dimethylarginine dimethylaminohydrolase 2. | 0.708 |
AKT1 | ESR1 | ENSCHIP00000027335 | ENSCHIP00000012243 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.734 |
AKT1 | IFNG | ENSCHIP00000027335 | ENSCHIP00000016152 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | 0.418 |
AKT1 | IL1B | ENSCHIP00000027335 | ENSCHIP00000029274 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.589 |
AKT1 | SMAD3 | ENSCHIP00000027335 | ENSCHIP00000011729 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Mothers against decapentaplegic homolog. | 0.512 |
AKT1 | TLR4 | ENSCHIP00000027335 | ENSCHIP00000019512 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.535 |
AKT1 | TNF | ENSCHIP00000027335 | ENSCHIP00000004561 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.622 |
ASL | ASS1 | ENSCHIP00000014908 | ENSCHIP00000018347 | Uncharacterized protein. | Argininosuccinate synthase 1. | 0.998 |
ASS1 | ASL | ENSCHIP00000018347 | ENSCHIP00000014908 | Argininosuccinate synthase 1. | Uncharacterized protein. | 0.998 |
CLEC7A | IFNG | ENSCHIP00000005201 | ENSCHIP00000016152 | C-type lectin domain containing 7A. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | 0.569 |
CLEC7A | IL1B | ENSCHIP00000005201 | ENSCHIP00000029274 | C-type lectin domain containing 7A. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.627 |
CLEC7A | TLR4 | ENSCHIP00000005201 | ENSCHIP00000019512 | C-type lectin domain containing 7A. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.658 |
CLEC7A | TNF | ENSCHIP00000005201 | ENSCHIP00000004561 | C-type lectin domain containing 7A. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.628 |
DDAH1 | AGXT2 | ENSCHIP00000029459 | ENSCHIP00000025513 | Dimethylarginine dimethylaminohydrolase 1. | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.868 |
DDAH2 | AGXT2 | ENSCHIP00000033039 | ENSCHIP00000025513 | Dimethylarginine dimethylaminohydrolase 2. | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.708 |
ESR1 | AKT1 | ENSCHIP00000012243 | ENSCHIP00000027335 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.734 |
ESR1 | IFNG | ENSCHIP00000012243 | ENSCHIP00000016152 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | 0.521 |
ESR1 | IL1B | ENSCHIP00000012243 | ENSCHIP00000029274 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.637 |
ESR1 | INSR | ENSCHIP00000012243 | ENSCHIP00000012457 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Tyrosine-protein kinase receptor. | 0.638 |