STRINGSTRING
ASL ASL MMP8 MMP8 IFNG IFNG PKD2 PKD2 AGXT2 AGXT2 AKT1 AKT1 IL1B IL1B ASS1 ASS1 TLR4 TLR4 DDAH1 DDAH1 DDAH2 DDAH2 TNF TNF KLF2 KLF2 CLEC7A CLEC7A KLRK1 KLRK1 PTX3 PTX3 SMAD3 SMAD3 ESR1 ESR1 INSR INSR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASLUncharacterized protein. (473 aa)
MMP8Matrix metallopeptidase 8. (470 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
ASS1Argininosuccinate synthase 1. (426 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (285 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
KLF2Kruppel like factor 2. (361 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
KLRK1Killer cell lectin like receptor K1. (208 aa)
PTX3Pentraxin 3. (380 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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