(32 nodes) Negative regulation of T cell differentiation network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	LOXL3	Lysyl oxidase like 3. (752 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	FGL2	Fibrinogen like 2. (441 aa)
	CLEC4G	C-type lectin domain family 4 member G. (291 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (539 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1250 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	TBX21	T-box transcription factor 21. (533 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	ANXA1	Annexin. (346 aa)
	CBFB	Core-binding factor subunit beta. (187 aa)
	TMEM131L	Transmembrane 131 like. (1599 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	SMAD7	Mothers against decapentaplegic homolog. (427 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1189 aa)
	ENSCHIP00000018611	Uncharacterized protein. (183 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	FOXP3	Forkhead box P3. (463 aa)
	HLX	H2.0 like homeobox. (488 aa)
	CD74	CD74 molecule. (261 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (417 aa)
	LAG3	Lymphocyte activating 3. (516 aa)
	ZC3H8	Zinc finger CCCH-type containing 8. (301 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	PRDX2	Thioredoxin domain-containing protein. (198 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (221 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	SOCS1	Suppressor of cytokine signaling 1. (219 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	ENSCHIP00000018611	ENSCHIP00000023293	ENSCHIP00000018611	Annexin.	Uncharacterized protein.	0.412
ANXA1	PRDX2	ENSCHIP00000023293	ENSCHIP00000004684	Annexin.	Thioredoxin domain-containing protein.	0.517
BCL6	CTLA4	ENSCHIP00000032540	ENSCHIP00000003886	BCL6 transcription repressor.	Cytotoxic T-lymphocyte associated protein 4.	0.773
BCL6	FOXP3	ENSCHIP00000032540	ENSCHIP00000012575	BCL6 transcription repressor.	Forkhead box P3.	0.913
BCL6	LAG3	ENSCHIP00000032540	ENSCHIP00000009958	BCL6 transcription repressor.	Lymphocyte activating 3.	0.464
BCL6	SOCS1	ENSCHIP00000032540	ENSCHIP00000001164	BCL6 transcription repressor.	Suppressor of cytokine signaling 1.	0.400
BCL6	TBX21	ENSCHIP00000032540	ENSCHIP00000025081	BCL6 transcription repressor.	T-box transcription factor 21.	0.765
BMP4	CBFB	ENSCHIP00000023678	ENSCHIP00000022846	Bone morphogenetic protein 4.	Core-binding factor subunit beta.	0.424
BMP4	GLI3	ENSCHIP00000023678	ENSCHIP00000014153	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.499
BMP4	IHH	ENSCHIP00000023678	ENSCHIP00000016239	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.790
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SMAD7	ENSCHIP00000023678	ENSCHIP00000021001	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.837
CBFB	BMP4	ENSCHIP00000022846	ENSCHIP00000023678	Core-binding factor subunit beta.	Bone morphogenetic protein 4.	0.424
CBFB	FOXP3	ENSCHIP00000022846	ENSCHIP00000012575	Core-binding factor subunit beta.	Forkhead box P3.	0.583
CBFB	IHH	ENSCHIP00000022846	ENSCHIP00000016239	Core-binding factor subunit beta.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.437
CD74	IRF1	ENSCHIP00000012352	ENSCHIP00000021648	CD74 molecule.	Interferon regulatory factor.	0.420
CLEC4G	LAG3	ENSCHIP00000030215	ENSCHIP00000009958	C-type lectin domain family 4 member G.	Lymphocyte activating 3.	0.470
CTLA4	BCL6	ENSCHIP00000003886	ENSCHIP00000032540	Cytotoxic T-lymphocyte associated protein 4.	BCL6 transcription repressor.	0.773
CTLA4	FGL2	ENSCHIP00000003886	ENSCHIP00000028063	Cytotoxic T-lymphocyte associated protein 4.	Fibrinogen like 2.	0.631
CTLA4	FOXP3	ENSCHIP00000003886	ENSCHIP00000012575	Cytotoxic T-lymphocyte associated protein 4.	Forkhead box P3.	0.921