STRINGSTRING
DUSP10 DUSP10 ENSCHIP00000022485 ENSCHIP00000022485 SASH3 SASH3 CBFB CBFB IL7R IL7R LOC102183203 LOC102183203 ANXA1 ANXA1 IL18 IL18 LOC102178618 LOC102178618 CD27 CD27 STAT5B STAT5B STAT5A STAT5A PTPRC PTPRC EGR3 EGR3 IL12A IL12A SHH SHH XBP1 XBP1 IL15 IL15 TOX TOX IL2 IL2 PIK3R6 PIK3R6 GATA3 GATA3 LEF1 LEF1 SHB SHB ZBTB7B ZBTB7B IL1RL2 IL1RL2 NFKBIZ NFKBIZ BCL6 BCL6 ADA ADA PCID2 PCID2 ZMIZ1 ZMIZ1 LOC102183503 LOC102183503 GIMAP5 GIMAP5 SOCS1 SOCS1 SOCS5 SOCS5 NKAP NKAP PCK1 PCK1 TNFSF9 TNFSF9 VSIR VSIR IL2RG IL2RG RHOH RHOH ENSCHIP00000003765 ENSCHIP00000003765 SOX12 SOX12 ZBTB16 ZBTB16 NCKAP1L NCKAP1L MYB MYB RASGRP1 RASGRP1 IL36B IL36B WNT10B WNT10B IL23A IL23A PRKCZ PRKCZ MMP14 MMP14 TGFBR2 TGFBR2 TGFB1 TGFB1 SYK SYK ZAP70 ZAP70 SOX13 SOX13 LOC108635823 LOC108635823 IL7 IL7 RAG1 RAG1 ENSCHIP00000011371 ENSCHIP00000011371 RHOA RHOA CD74 CD74 IL4I1 IL4I1 HLX HLX FOXP3 FOXP3 RARA RARA PPP2R3C PPP2R3C GLI3 GLI3 BAD BAD KAT5 KAT5 GAS6 GAS6 ITPKB ITPKB SART1 SART1 IFNG IFNG IHH IHH MALT1 MALT1 LOC102170474 LOC102170474 AMBRA1 AMBRA1 CD83 CD83 VNN1 VNN1 FOXO3 FOXO3 CCL19 CCL19 RIPK2 RIPK2 INPP5D INPP5D AP3B1 AP3B1 IL4 IL4 ADAM8 ADAM8 ZBTB1 ZBTB1 AXL AXL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ENSCHIP00000022485AIG1-type G domain-containing protein. (295 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
CBFBCore-binding factor subunit beta. (187 aa)
IL7RInterleukin 7 receptor. (459 aa)
LOC102183203Amine oxidase. (517 aa)
ANXA1Annexin. (346 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LOC102178618AIG1-type G domain-containing protein. (214 aa)
CD27CD27 molecule. (270 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
EGR3Early growth response 3. (387 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
XBP1BZIP domain-containing protein. (261 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
TOXThymocyte selection associated high mobility group box. (527 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (762 aa)
GATA3GATA binding protein 3. (467 aa)
LEF1HMG box domain-containing protein. (430 aa)
SHBSH2 domain-containing protein. (507 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (539 aa)
IL1RL2Interleukin 1 receptor like 2. (552 aa)
NFKBIZMolecule possessing ankyrin-repeats induced by lipopolysaccharide. (719 aa)
BCL6BCL6 transcription repressor. (706 aa)
ADAAdenosine deaminase. (400 aa)
PCID2PCI domain containing 2. (393 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1072 aa)
LOC102183503AIG1-type G domain-containing protein. (309 aa)
GIMAP5AIG1-type G domain-containing protein. (298 aa)
SOCS1Suppressor of cytokine signaling 1. (219 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
NKAPNFKB activating protein. (370 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
TNFSF9TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa)
VSIRV-set immunoregulatory receptor. (312 aa)
IL2RGFibronectin type-III domain-containing protein. (378 aa)
RHOHRas homolog family member H. (191 aa)
ENSCHIP00000003765AIG1-type G domain-containing protein. (277 aa)
SOX12Transcription factor SOX. (314 aa)
ZBTB16Uncharacterized protein. (673 aa)
NCKAP1LNCK associated protein 1 like. (1178 aa)
MYBMYB proto-oncogene, transcription factor. (640 aa)
RASGRP1RAS guanyl releasing protein 1. (773 aa)
IL36BInterleukin-1. (158 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
MMP14ZnMc domain-containing protein. (584 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
ZAP70Tyrosine-protein kinase. (622 aa)
SOX13SRY-box transcription factor 13. (592 aa)
LOC108635823AIG1-type G domain-containing protein. (297 aa)
IL7Interleukin 7. (181 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
RHOARas-like protein family member A. (193 aa)
CD74CD74 molecule. (261 aa)
IL4I1Interleukin 4 induced 1. (582 aa)
HLXH2.0 like homeobox. (488 aa)
FOXP3Forkhead box P3. (463 aa)
RARARetinoic acid receptor alpha. (462 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GLI3GLI family zinc finger 3. (1614 aa)
BADBCL2 associated agonist of cell death. (198 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
GAS6Growth arrest specific 6. (671 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (942 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (796 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MALT1MALT1 paracaspase. (830 aa)
LOC102170474Uncharacterized protein. (238 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1300 aa)
CD83CD83 molecule. (199 aa)
VNN1Vanin 1. (529 aa)
FOXO3Forkhead box O3. (672 aa)
CCL19C-C motif chemokine. (102 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1202 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
ADAM8ADAM metallopeptidase domain 8. (827 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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