(17 nodes) Regulation of macrophage differentiation network (Capra hircus)

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Your Input:
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (488 aa)
	IL34	Interleukin 34. (233 aa)
	TRIB1	Tribbles pseudokinase 1. (372 aa)
	PRKCA	Uncharacterized protein. (605 aa)
	ENSCHIP00000031987	Non-specific serine/threonine protein kinase. (199 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (471 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	ADIPOQ	C1q domain-containing protein. (283 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	ZBTB46	Zinc finger and BTB domain containing 46. (589 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (417 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	C1QC	Complement C1q C chain. (244 aa)
	HSF1	HSF_DOMAIN domain-containing protein. (537 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
	RB1	RB transcriptional corepressor 1. (931 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	TGFB1	ENSCHIP00000032803	ENSCHIP00000008885	C1q domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.432
CASP8	FADD	ENSCHIP00000020513	ENSCHIP00000004023	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	RIPK1	ENSCHIP00000020513	ENSCHIP00000032711	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.999
CSF1	IL34	ENSCHIP00000033660	ENSCHIP00000022249	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Interleukin 34.	0.994
CSF1	LIF	ENSCHIP00000033660	ENSCHIP00000012397	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	LIF interleukin 6 family cytokine.	0.438
CSF1	TGFB1	ENSCHIP00000033660	ENSCHIP00000008885	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.636
ENSCHIP00000031987	PRKCA	ENSCHIP00000031987	ENSCHIP00000029152	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.806
FADD	CASP8	ENSCHIP00000004023	ENSCHIP00000020513	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.999
FADD	RIPK1	ENSCHIP00000004023	ENSCHIP00000032711	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.999
IL34	CSF1	ENSCHIP00000022249	ENSCHIP00000033660	Interleukin 34.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.994
LIF	CSF1	ENSCHIP00000012397	ENSCHIP00000033660	LIF interleukin 6 family cytokine.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.438
LIF	TGFB1	ENSCHIP00000012397	ENSCHIP00000008885	LIF interleukin 6 family cytokine.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.484
PRKCA	ENSCHIP00000031987	ENSCHIP00000029152	ENSCHIP00000031987	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.806
RIPK1	CASP8	ENSCHIP00000032711	ENSCHIP00000020513	Receptor interacting serine/threonine kinase 1.	Caspase 8; Belongs to the peptidase C14A family.	0.999
RIPK1	FADD	ENSCHIP00000032711	ENSCHIP00000004023	Receptor interacting serine/threonine kinase 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
TGFB1	ADIPOQ	ENSCHIP00000008885	ENSCHIP00000032803	Transforming growth factor beta; Belongs to the TGF-beta family.	C1q domain-containing protein.	0.432
TGFB1	CSF1	ENSCHIP00000008885	ENSCHIP00000033660	Transforming growth factor beta; Belongs to the TGF-beta family.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.636
TGFB1	LIF	ENSCHIP00000008885	ENSCHIP00000012397	Transforming growth factor beta; Belongs to the TGF-beta family.	LIF interleukin 6 family cytokine.	0.484