STRINGSTRING
XKR8 XKR8 TGFB1 TGFB1 TBX3 TBX3 SOSTDC1 SOSTDC1 PRICKLE1 PRICKLE1 SOX4 SOX4 SRA1 SRA1 PPARD PPARD MYF5 MYF5 HIF1AN HIF1AN CXCL10 CXCL10 KAT5 KAT5 MBNL3 MBNL3 AKIRIN1 AKIRIN1 MEF2C MEF2C SOX8 SOX8 SMYD1 SMYD1 FLOT2 FLOT2 DLL1 DLL1 IL18 IL18 BMP4 BMP4 NOTCH1 NOTCH1 MYOCD MYOCD MYOG MYOG CXCL9 CXCL9 CMTM5 CMTM5 ID3 ID3 IGFBP3 IGFBP3 MAP3K5 MAP3K5 RANBP3L RANBP3L TRIP4 TRIP4 CAPN3 CAPN3 LOC108633275 LOC108633275 MSTN MSTN ZFP36L1 ZFP36L1 KLHL41 KLHL41 SOX9 SOX9 MYF6 MYF6 TMEM182 TMEM182 BOC BOC DDIT3 DDIT3 LRRC8A LRRC8A CDON CDON RIPOR2 RIPOR2 TNF TNF CXCL14 CXCL14 NMRK2 NMRK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XKR8XK-related protein. (399 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TBX3T-box transcription factor 3. (749 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
PRICKLE1Prickle planar cell polarity protein 1. (834 aa)
SOX4SRY-box transcription factor 4. (504 aa)
SRA1Steroid receptor RNA activator 1. (261 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (260 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (385 aa)
CXCL10C-X-C motif chemokine. (102 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
MBNL3Muscleblind like splicing regulator 3. (374 aa)
AKIRIN1Akirin 1. (192 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
SOX8SRY-box transcription factor 8. (534 aa)
SMYD1SET and MYND domain containing 1. (494 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (445 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NOTCH1Notch receptor 1. (2508 aa)
MYOCDMyocardin. (982 aa)
MYOGMyogenin. (224 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5. (182 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (151 aa)
IGFBP3Uncharacterized protein. (293 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
RANBP3LRAN binding protein 3 like. (466 aa)
TRIP4Thyroid hormone receptor interactor 4. (571 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (819 aa)
LOC108633275TNF_2 domain-containing protein. (230 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
KLHL41Kelch like family member 41. (606 aa)
SOX9SRY-box transcription factor 9. (525 aa)
MYF6BHLH domain-containing protein. (242 aa)
TMEM182Transmembrane protein 182. (229 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1116 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
CDONCell adhesion associated, oncogene regulated. (1254 aa)
RIPOR2Uncharacterized protein. (1052 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
CXCL14C-X-C motif chemokine ligand 14. (99 aa)
NMRK2Nicotinamide riboside kinase 2. (195 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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