STRINGSTRING
VEGFC VEGFC RASSF2 RASSF2 TENT5A TENT5A CLIC1 CLIC1 ID3 ID3 SNAI2 SNAI2 HOXA2 HOXA2 HDAC7 HDAC7 SMAD6 SMAD6 TMEM119 TMEM119 CTHRC1 CTHRC1 BMP2 BMP2 TNFAIP6 TNFAIP6 FBN2 FBN2 ACVR2A ACVR2A MEN1 MEN1 SMAD3 SMAD3 PTCH1 PTCH1 SUCO SUCO SFRP1 SFRP1 ENSCHIP00000012753 ENSCHIP00000012753 SMAD5 SMAD5 ATF4 ATF4 ATRAID ATRAID CCN4 CCN4 BAMBI BAMBI GLI3 GLI3 TMEM64 TMEM64 REST REST RUNX2 RUNX2 MEF2C MEF2C TNN TNN PRKACA PRKACA FGF23 FGF23 LTF LTF WDR63 WDR63 YAP1 YAP1 LRP3 LRP3 WWTR1 WWTR1 ILK ILK SCUBE2 SCUBE2 LIMD1 LIMD1 PRKD1 PRKD1 BMPR1B BMPR1B FGF2 FGF2 HDAC4 HDAC4 IGF1 IGF1 NPNT NPNT LRP5 LRP5 BMPR2 BMPR2 AXIN2 AXIN2 JAG1 JAG1 OSTN OSTN BMP4 BMP4 NOTCH1 NOTCH1 ZHX3 ZHX3 SOX9 SOX9 TCIRG1 TCIRG1 DDR2 DDR2 SFRP2 SFRP2 TWIST1 TWIST1 PDLIM7 PDLIM7 FFAR4 FFAR4 CDK6 CDK6 SMOC1 SMOC1 SKI SKI CHRD CHRD SMAD1 SMAD1 WNT10B WNT10B GREM1 GREM1 GDF10 GDF10 CRIM1 CRIM1 BMP7 BMP7 NOG NOG TNF TNF IL6ST IL6ST TWIST2 TWIST2 GLI1 GLI1 TOB1 TOB1 SEMA4D SEMA4D BMPR1A BMPR1A HAND2 HAND2 RIOX1 RIOX1 SOX11 SOX11 GDPD2 GDPD2 UCMA UCMA CTNNB1 CTNNB1 RORB RORB CEBPB CEBPB TWSG1 TWSG1 BMP6 BMP6 PPP3CA PPP3CA FBXO5 FBXO5 ENSCHIP00000033232 ENSCHIP00000033232 CCN1 CCN1 HEMGN HEMGN SCUBE3 SCUBE3 NBR1 NBR1 NOCT NOCT TP63 TP63 FERMT2 FERMT2 RANBP3L RANBP3L FNDC3B FNDC3B CTNNBIP1 CTNNBIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
RASSF2Ras association domain family member 2. (326 aa)
TENT5ATerminal nucleotidyltransferase 5A. (412 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (151 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
HOXA2Homeobox A2. (372 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
TMEM119Transmembrane protein 119. (284 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
FBN2Fibrillin 2. (2900 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
MEN1Menin 1. (609 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PTCH1Patched 1. (1453 aa)
SUCOSUN domain containing ossification factor. (1254 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
ENSCHIP00000012753Uncharacterized protein. (184 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ATF4Activating transcription factor 4. (352 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (229 aa)
CCN4Cellular communication network factor 4. (368 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
GLI3GLI family zinc finger 3. (1614 aa)
TMEM64Transmembrane protein 64. (383 aa)
RESTUncharacterized protein. (998 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
TNNTenascin N. (1384 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (360 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (754 aa)
WDR63WD repeat domain 63. (892 aa)
YAP1Yes associated protein 1. (503 aa)
LRP3LDL receptor related protein 3. (782 aa)
WWTR1WW domain containing transcription regulator 1. (419 aa)
ILKIntegrin linked kinase. (452 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1022 aa)
LIMD1LIM domains containing 1. (671 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
NPNTNephronectin. (606 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
AXIN2Axin 2. (844 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
OSTNOsteocrin. (132 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NOTCH1Notch receptor 1. (2508 aa)
ZHX3Zinc fingers and homeoboxes 3. (943 aa)
SOX9SRY-box transcription factor 9. (525 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (889 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TWIST1BHLH domain-containing protein. (163 aa)
PDLIM7PDZ and LIM domain 7. (508 aa)
FFAR4Free fatty acid receptor 4. (378 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
SMOC1SPARC related modular calcium binding 1. (435 aa)
SKISKI proto-oncogene. (729 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (957 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
GREM1Gremlin. (184 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (478 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1035 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
GLI1GLI family zinc finger 1. (1105 aa)
TOB1Transducer of ERBB2, 1. (342 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (594 aa)
SOX11Transcription factor SOX. (444 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (513 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (132 aa)
CTNNB1Catenin beta 1. (781 aa)
RORBRAR related orphan receptor B. (468 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
FBXO5F-box protein 5. (448 aa)
ENSCHIP00000033232Uncharacterized protein. (321 aa)
CCN1Cellular communication network factor 1. (382 aa)
HEMGNHemogen. (448 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (936 aa)
NBR1NBR1 autophagy cargo receptor. (988 aa)
NOCTNocturnin. (530 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
FERMT2Fermitin family member 2. (680 aa)
RANBP3LRAN binding protein 3 like. (466 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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