(42 nodes) Negative regulation of osteoblast differentiation network (Capra hircus)

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Predicted Interactions

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Your Input:
	TWIST1	BHLH domain-containing protein. (163 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (863 aa)
	TOB1	Transducer of ERBB2, 1. (342 aa)
	TWIST2	Twist family bHLH transcription factor 2. (160 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	CRIM1	Cysteine rich transmembrane BMP regulator 1. (1035 aa)
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (478 aa)
	GREM1	Gremlin. (184 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (957 aa)
	SKI	SKI proto-oncogene. (729 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
	SMAD6	Mothers against decapentaplegic homolog. (497 aa)
	TNFAIP6	TNF alpha induced protein 6. (280 aa)
	MEN1	Menin 1. (609 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	PTCH1	Patched 1. (1453 aa)
	SFRP1	Secreted frizzled related protein 1. (308 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	TMEM64	Transmembrane protein 64. (383 aa)
	TNN	Tenascin N. (1384 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
	LIMD1	LIM domains containing 1. (671 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	AXIN2	Axin 2. (844 aa)
	OSTN	Osteocrin. (132 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	NBR1	NBR1 autophagy cargo receptor. (988 aa)
	NOCT	Nocturnin. (530 aa)
	RANBP3L	RAN binding protein 3 like. (466 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (151 aa)
	HOXA2	Homeobox A2. (372 aa)
	RIOX1	Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (594 aa)
	UCMA	Upper zone of growth plate and cartilage matrix associated. (132 aa)
	RORB	RAR related orphan receptor B. (468 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	LRP5	ENSCHIP00000022676	ENSCHIP00000021146	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.946
AXIN2	NOG	ENSCHIP00000022676	ENSCHIP00000005264	Axin 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.607
AXIN2	PTCH1	ENSCHIP00000022676	ENSCHIP00000011891	Axin 2.	Patched 1.	0.601
AXIN2	SFRP1	ENSCHIP00000022676	ENSCHIP00000012579	Axin 2.	Secreted frizzled related protein 1.	0.789
AXIN2	SOX9	ENSCHIP00000022676	ENSCHIP00000024523	Axin 2.	SRY-box transcription factor 9.	0.731
AXIN2	TWIST1	ENSCHIP00000022676	ENSCHIP00000009424	Axin 2.	BHLH domain-containing protein.	0.463
BAMBI	CHRD	ENSCHIP00000013920	ENSCHIP00000008141	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.517
BAMBI	LRP5	ENSCHIP00000013920	ENSCHIP00000021146	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.923
BAMBI	NOG	ENSCHIP00000013920	ENSCHIP00000005264	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.470
BAMBI	SMAD3	ENSCHIP00000013920	ENSCHIP00000011729	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.733
BAMBI	SMAD6	ENSCHIP00000013920	ENSCHIP00000009966	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.824
CDK6	NOTCH1	ENSCHIP00000008415	ENSCHIP00000023681	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Notch receptor 1.	0.495
CDK6	SMAD3	ENSCHIP00000008415	ENSCHIP00000011729	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.416
CHRD	BAMBI	ENSCHIP00000008141	ENSCHIP00000013920	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.517
CHRD	GREM1	ENSCHIP00000008141	ENSCHIP00000006985	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Gremlin.	0.429
CHRD	NOG	ENSCHIP00000008141	ENSCHIP00000005264	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.912
CHRD	SMAD3	ENSCHIP00000008141	ENSCHIP00000011729	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Mothers against decapentaplegic homolog.	0.418
CHRD	SMAD6	ENSCHIP00000008141	ENSCHIP00000009966	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Mothers against decapentaplegic homolog.	0.738
CHRD	TNFAIP6	ENSCHIP00000008141	ENSCHIP00000010743	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	TNF alpha induced protein 6.	0.578
CHRD	TWSG1	ENSCHIP00000008141	ENSCHIP00000032482	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Twisted gastrulation BMP signaling modulator 1.	0.910