STRINGSTRING
ENSCHIP00000008932 ENSCHIP00000008932 GPR137B GPR137B FSTL3 FSTL3 IL23A IL23A NF1 NF1 PIAS3 PIAS3 TMEM178A TMEM178A GPR68 GPR68 TNF TNF TREM2 TREM2 PPARGC1B PPARGC1B PRXL2A PRXL2A TOB2 TOB2 LRRC17 LRRC17 MTOR MTOR IL4 IL4 INPP5D INPP5D GPR137 GPR137 LOC102181154 LOC102181154 IL12B IL12B LTF LTF KLF10 KLF10 IFNG IFNG GPR55 GPR55 TRAF6 TRAF6 TMEM64 TMEM64 TNFSF11 TNFSF11 IAPP IAPP TCTA TCTA SFRP1 SFRP1 SLC9B2 SLC9B2 TNFRSF11B TNFRSF11B POU4F1 POU4F1 TFE3 TFE3 FOS FOS CTNNB1 CTNNB1 CEBPB CEBPB PPP3CA PPP3CA UBASH3B UBASH3B CSF1 CSF1 CREB1 CREB1 FBXW9 FBXW9 RASSF2 RASSF2 FBXW7 FBXW7 CLDN18 CLDN18 NOTCH2 NOTCH2 IL17A IL17A MITF MITF FBN1 FBN1 PIK3R1 PIK3R1 FSHR FSHR NEDD9 NEDD9 OCSTAMP OCSTAMP TNFAIP6 TNFAIP6 MAFB MAFB IL20 IL20 POU4F2 POU4F2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000008932Uncharacterized protein. (166 aa)
GPR137BG protein-coupled receptor 137B. (394 aa)
FSTL3Follistatin like 3. (274 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
NF1Neurofibromin 1. (2848 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (371 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
PPARGC1BPPARG coactivator 1 beta. (1021 aa)
PRXL2APeroxiredoxin like 2A. (229 aa)
TOB2Transducer of ERBB2, 2. (345 aa)
LRRC17Leucine rich repeat containing 17. (443 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1202 aa)
GPR137G protein-coupled receptor 137. (402 aa)
LOC102181154C-C motif chemokine. (93 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (754 aa)
KLF10Kruppel like factor 10. (482 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (329 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
TMEM64Transmembrane protein 64. (383 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
IAPPIslet amyloid polypeptide. (94 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (122 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
SLC9B2Solute carrier family 9 member B2. (535 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
POU4F1POU domain protein. (421 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (573 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CTNNB1Catenin beta 1. (781 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
RASSF2Ras association domain family member 2. (326 aa)
FBXW7F-box and WD repeat domain containing 7. (705 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
NOTCH2Notch receptor 2. (2471 aa)
IL17AInterleukin-17A. (153 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
FBN1Fibrillin 1. (2860 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (670 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (826 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (513 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
MAFBMAF bZIP transcription factor B. (329 aa)
IL20Interleukin 20. (175 aa)
POU4F2POU domain protein. (408 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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