(46 nodes) Regulation of glial cell differentiation network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP2	TGF_BETA_2 domain-containing protein. (381 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	TENM4	Teneurin transmembrane protein 4. (2855 aa)
	PTN	Pleiotrophin. (183 aa)
	TNFRSF21	TNF receptor superfamily member 21. (652 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ASPA	Aspartoacylase. (313 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	EPHA4	EPH receptor A4. (986 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	ZNF365	Zinc finger protein 365. (406 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	NKX6-1	NK6 homeobox 1. (367 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	DUSP15	Dual specificity phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (228 aa)
	DLX6	Distal-less homeobox 6. (230 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (459 aa)
	IL34	Interleukin 34. (233 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	LDLR	Low density lipoprotein receptor. (787 aa)
	EGR2	Early growth response 2. (472 aa)
	BIN1	Bridging integrator 1. (587 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	GSX2	GS homeobox 2. (305 aa)
	CNTN2	Contactin 2. (1046 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (616 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (220 aa)
	OPALIN	Oligodendrocytic myelin paranodal and inner loop protein. (151 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (397 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1087 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	NF1	Neurofibromin 1. (2848 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (478 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	RNF112	Ring finger protein 112. (628 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	IL6ST	Interleukin 6 signal transducer. (918 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (329 aa)
	NKX6-2	NK6 homeobox 2. (286 aa)
	SLC45A3	Solute carrier family 45 member 3. (550 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPA	OLIG2	ENSCHIP00000030855	ENSCHIP00000003324	Aspartoacylase.	Oligodendrocyte transcription factor 2.	0.725
BIN1	CTNNB1	ENSCHIP00000018547	ENSCHIP00000031016	Bridging integrator 1.	Catenin beta 1.	0.482
BIN1	TREM2	ENSCHIP00000018547	ENSCHIP00000003876	Bridging integrator 1.	Triggering receptor expressed on myeloid cells 2.	0.497
BMP2	CTNNB1	ENSCHIP00000010414	ENSCHIP00000031016	TGF_BETA_2 domain-containing protein.	Catenin beta 1.	0.701
BMP2	NOG	ENSCHIP00000010414	ENSCHIP00000005264	TGF_BETA_2 domain-containing protein.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.995
BMP2	SHH	ENSCHIP00000010414	ENSCHIP00000027767	TGF_BETA_2 domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.543
BMP2	TGFB1	ENSCHIP00000010414	ENSCHIP00000008885	TGF_BETA_2 domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.517
CLCF1	IL6ST	ENSCHIP00000017289	ENSCHIP00000003863	Cardiotrophin like cytokine factor 1.	Interleukin 6 signal transducer.	0.936
CLCF1	LIF	ENSCHIP00000017289	ENSCHIP00000012397	Cardiotrophin like cytokine factor 1.	LIF interleukin 6 family cytokine.	0.423
CNTN2	NKX6-2	ENSCHIP00000018185	ENSCHIP00000000992	Contactin 2.	NK6 homeobox 2.	0.422
CTNNB1	BIN1	ENSCHIP00000031016	ENSCHIP00000018547	Catenin beta 1.	Bridging integrator 1.	0.482
CTNNB1	BMP2	ENSCHIP00000031016	ENSCHIP00000010414	Catenin beta 1.	TGF_BETA_2 domain-containing protein.	0.701
CTNNB1	DAAM2	ENSCHIP00000031016	ENSCHIP00000013273	Catenin beta 1.	Dishevelled associated activator of morphogenesis 2.	0.472
CTNNB1	HDAC1	ENSCHIP00000031016	ENSCHIP00000022688	Catenin beta 1.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.831
CTNNB1	HES5	ENSCHIP00000031016	ENSCHIP00000025014	Catenin beta 1.	Hes family bHLH transcription factor 5.	0.449
CTNNB1	LIF	ENSCHIP00000031016	ENSCHIP00000012397	Catenin beta 1.	LIF interleukin 6 family cytokine.	0.467
CTNNB1	MTOR	ENSCHIP00000031016	ENSCHIP00000021872	Catenin beta 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.517
CTNNB1	NOG	ENSCHIP00000031016	ENSCHIP00000005264	Catenin beta 1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.707
CTNNB1	NOTCH1	ENSCHIP00000031016	ENSCHIP00000023681	Catenin beta 1.	Notch receptor 1.	0.900
CTNNB1	OLIG2	ENSCHIP00000031016	ENSCHIP00000003324	Catenin beta 1.	Oligodendrocyte transcription factor 2.	0.513