STRINGSTRING
JAK1 JAK1 AGGF1 AGGF1 HK2 HK2 CYP1B1 CYP1B1 BTG1 BTG1 S100A1 S100A1 VASH2 VASH2 ENSCHIP00000008714 ENSCHIP00000008714 EMP2 EMP2 ANXA3 ANXA3 TGFBR2 TGFBR2 FGF18 FGF18 PTGIS PTGIS SMAD1 SMAD1 IL1A IL1A CELA1 CELA1 C5 C5 SIRT1 SIRT1 ITGB1 ITGB1 ECM1 ECM1 CCL24 CCL24 RAPGEF3 RAPGEF3 GREM1 GREM1 AGO2 AGO2 CHRNA7 CHRNA7 RAMP2 RAMP2 VEGFA VEGFA C3 C3 PDCD6 PDCD6 CX3CR1 CX3CR1 C3AR1 C3AR1 HSPB6 HSPB6 KDR KDR CHI3L1 CHI3L1 JMJD8 JMJD8 CCBE1 CCBE1 EMILIN2 EMILIN2 NODAL NODAL SMOC2 SMOC2 VEGFB VEGFB GAB1 GAB1 ENSCHIP00000029391 ENSCHIP00000029391 APELA APELA IL1B IL1B PRKCA PRKCA CD40 CD40 VEGFC VEGFC AAMP AAMP VEGFD VEGFD APLNR APLNR XBP1 XBP1 HYAL1 HYAL1 SFRP2 SFRP2 ISL1 ISL1 PGF PGF ZC3H12A ZC3H12A ABL1 ABL1 SPHK1 SPHK1 EPHA1 EPHA1 PRKD2 PRKD2 HIPK2 HIPK2 DLL1 DLL1 NR2E1 NR2E1 STAT3 STAT3 MTDH MTDH EMILIN1 EMILIN1 CXCL8 CXCL8 FUT1 FUT1 FLT1 FLT1 ITGB8 ITGB8 GATA6 GATA6 BMPER BMPER ANGPTL3 ANGPTL3 FGF2 FGF2 ANGPT4 ANGPT4 GDF2 GDF2 THBS1 THBS1 PRKD1 PRKD1 ZNF304 ZNF304 LRG1 LRG1 PRKCB PRKCB LOC102170474 LOC102170474 MYDGF MYDGF HMOX1 HMOX1 TNN TNN C5AR1 C5AR1 WNT5A WNT5A PKM PKM HSPB1 HSPB1 TLR3 TLR3 ETS1 ETS1 EMC10 EMC10 ACVRL1 ACVRL1 ENG ENG FGF1 FGF1 BRCA1 BRCA1 AQP1 AQP1 JUP JUP PTK2B PTK2B ENSCHIP00000031987 ENSCHIP00000031987 CTSH CTSH SIRT6 SIRT6 AKT3 AKT3 RRAS RRAS PIK3R6 PIK3R6 HIF1A HIF1A CDH5 CDH5 PDPK1 PDPK1 PAK4 PAK4 CXCR3 CXCR3 ITGA5 ITGA5 SASH1 SASH1 FUT2 FUT2 TEK TEK JCAD JCAD TIE1 TIE1 PDCL3 PDCL3 NOS3 NOS3 CCL11 CCL11 SP1 SP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1159 aa)
AGGF1Uncharacterized protein. (714 aa)
HK2Hexokinase 2. (917 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
BTG1B-cell translocation protein 1. (171 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
VASH2Vasohibin 2. (355 aa)
ENSCHIP00000008714Uncharacterized protein. (170 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ANXA3Annexin. (323 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (266 aa)
C5Complement C5. (1675 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ECM1Extracellular matrix protein 1. (524 aa)
CCL24C-C motif chemokine ligand 24. (116 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (924 aa)
GREM1Gremlin. (184 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
CHRNA7Uncharacterized protein. (559 aa)
RAMP2Receptor activity modifying protein 2. (177 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
C3Complement C3. (1663 aa)
PDCD6Uncharacterized protein. (185 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (476 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (164 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
CHI3L1Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (391 aa)
JMJD8Jumonji domain containing 8. (344 aa)
CCBE1Collagen and calcium binding EGF domains 1. (407 aa)
EMILIN2Elastin microfibril interfacer 2. (1076 aa)
NODALNodal growth differentiation factor. (346 aa)
SMOC2SPARC related modular calcium binding 2. (445 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
ENSCHIP00000029391Uncharacterized protein. (179 aa)
APELAUncharacterized protein. (54 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
PRKCAUncharacterized protein. (605 aa)
CD40CD40 molecule. (280 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
AAMPAngio associated migratory cell protein. (435 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
XBP1BZIP domain-containing protein. (261 aa)
HYAL1Hyaluronidase. (450 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (140 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
SPHK1Sphingosine kinase 1. (392 aa)
EPHA1EPH receptor A1. (968 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
HIPK2Homeodomain interacting protein kinase 2. (1228 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MTDHMetadherin. (583 aa)
EMILIN1Elastin microfibril interfacer 1. (1017 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (348 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (772 aa)
GATA6GATA binding protein 6. (592 aa)
BMPERBMP binding endothelial regulator. (685 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (459 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ANGPT4Angiopoietin 4. (498 aa)
GDF2Growth differentiation factor 2. (430 aa)
THBS1Thrombospondin 1. (1218 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
ZNF304Zinc finger protein 304. (662 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (353 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC102170474Uncharacterized protein. (238 aa)
MYDGFMyeloid derived growth factor. (174 aa)
HMOX1Heme oxygenase 1. (288 aa)
TNNTenascin N. (1384 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
ETS1Uncharacterized protein. (485 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ENGEndoglin. (649 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
JUPJunction plakoglobin. (745 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSCHIP00000031987Non-specific serine/threonine protein kinase. (199 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
SIRT6Sirtuin 6. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RRASRAS related. (218 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (762 aa)
HIF1AUncharacterized protein. (823 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PAK4Non-specific serine/threonine protein kinase. (584 aa)
CXCR3C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (367 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1100 aa)
SASH1SAM and SH3 domain containing 1. (1236 aa)
FUT2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (339 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
JCADJunctional cadherin 5 associated. (1301 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
PDCL3Phosducin like 3. (241 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
CCL11C-C motif chemokine. (97 aa)
SP1Uncharacterized protein. (786 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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