Your Input: | |
| | CHMP4C | Charged multivesicular body protein 4C. (236 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (161 aa) |
| | RB1 | RB transcriptional corepressor 1. (931 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | ENSCHIP00000001380 | Reverse transcriptase domain-containing protein. (704 aa) |
| | MIIP | Migration and invasion inhibitory protein. (429 aa) |
| | LOC102177756 | HTH_48 domain-containing protein. (337 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | ENSCHIP00000000271 | Uncharacterized protein. (78 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (647 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | FBXO5 | F-box protein 5. (448 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) |
| | FANCD2 | FA complementation group D2. (1423 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa) |
| | NME6 | Nucleoside diphosphate kinase. (186 aa) |
| | TEX14 | Testis expressed 14, intercellular bridge forming factor. (1479 aa) |
| | ZW10 | Zw10 kinetochore protein. (779 aa) |
| | INHBA | Inhibin beta A subunit. (425 aa) |
| | ENSCHIP00000031547 | HTH_48 domain-containing protein. (342 aa) |
| | INTS3 | Integrator complex subunit 3. (1041 aa) |
| | STK33 | Serine/threonine kinase 33; Belongs to the protein kinase superfamily. (473 aa) |
| | GPR132 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | FBXO7 | F-box protein 7. (523 aa) |
| | ZNF655 | Zinc finger protein 655. (543 aa) |
| | NABP1 | Nucleic acid binding protein 1. (205 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (508 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | TOM1L2 | Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family. (521 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (490 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1140 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (901 aa) |
| | APC | APC regulator of WNT signaling pathway. (2880 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | BRD7 | Bromodomain containing 7. (654 aa) |
| | PLK5 | Protein kinase domain-containing protein. (562 aa) |
| | CHEK2 | Checkpoint kinase 2. (534 aa) |
| | CCL2 | C-C motif chemokine. (98 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | E2F7 | E2F transcription factor 7. (911 aa) |
| | CRADD | CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa) |
| | CLSPN | Claspin. (1339 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (795 aa) |
| | HECA | Hdc homolog, cell cycle regulator. (504 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (602 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | GPNMB | Glycoprotein nmb. (555 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (647 aa) |
| | ZFYVE19 | Zinc finger FYVE-type containing 19. (385 aa) |
| | CTDSP1 | CTD small phosphatase 1. (261 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (453 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | MUC1 | SEA domain-containing protein. (578 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (725 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa) |
| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa) |
| | CRLF3 | Cytokine receptor like factor 3. (442 aa) |
| | CHFR | Checkpoint with forkhead and ring finger domains. (662 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (328 aa) |
| | CDK2AP2 | Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (127 aa) |
| | KHDC3L | MOEP19 domain-containing protein. (325 aa) |
| | LRRC1 | Leucine rich repeat containing 1. (517 aa) |
| | PHKG1 | Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa) |
| | SYF2 | SYF2 pre-mRNA splicing factor. (243 aa) |
| | PIDD1 | P53-induced death domain protein 1. (913 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (831 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (709 aa) |
| | TRIM39 | Tripartite motif containing 39. (488 aa) |
| | DONSON | Downstream neighbor of SON. (561 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (978 aa) |
| | CTDSP2 | CTD small phosphatase 2. (271 aa) |
| | TAOK3 | TAO kinase 3. (930 aa) |
| | SCRIB | Scribble planar cell polarity protein. (1582 aa) |
| | PTPN3 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (905 aa) |
| | ENSCHIP00000020042 | MPN domain-containing protein. (245 aa) |
| | BRCC3 | MPN domain-containing protein. (288 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (761 aa) |
| | C10orf90 | Chromosome 10 open reading frame 90. (696 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (456 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (877 aa) |
| | BTG2 | BTG anti-proliferation factor 2. (164 aa) |
| | BRINP3 | BMP/retinoic acid inducible neural specific 3. (734 aa) |
| | KANK2 | KN motif and ankyrin repeat domains 2. (858 aa) |
| | TAOK1 | TAO kinase 1. (1001 aa) |
| | MRNIP | MRN complex interacting protein. (361 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (267 aa) |
| | BTG4 | BTG anti-proliferation factor 4. (229 aa) |
| | TPRA1 | Transmembrane protein adipocyte associated 1. (362 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (410 aa) |
| | BCL2 | BH4_2 domain-containing protein. (229 aa) |
| | INIP | INTS3 and NABP interacting protein. (102 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (580 aa) |
| | BUB1B | Uncharacterized protein. (1062 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | CTDSPL | CTD small phosphatase like. (276 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa) |
| | ZWILCH | Zwilch kinetochore protein. (589 aa) |
| | ANGEL2 | Angel homolog 2. (544 aa) |
| | DCUN1D3 | DCN1-like protein. (304 aa) |
| | GML | UPAR/Ly6 domain-containing protein. (154 aa) |
| | JADE1 | Jade family PHD finger 1. (863 aa) |
| | NABP2 | Nucleic acid binding protein 2. (175 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (603 aa) |
| | TAOK2 | TAO kinase 2. (1242 aa) |
| | TOM1L1 | Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (473 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (513 aa) |
| | BRINP2 | BMP/retinoic acid inducible neural specific 2. (784 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2436 aa) |
| | MTBP | MDM2 binding protein. (892 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (791 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa) |
| | BIRC5 | Uncharacterized protein. (142 aa) |
| | FOXO4 | Forkhead box O4. (535 aa) |
| | ZNF207 | Zinc finger protein 207. (494 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa) |
| | ENSCHIP00000010204 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) |
| | FBXO31 | F-box protein 31. (560 aa) |
| | ZNF830 | Zinc finger protein 830. (361 aa) |
| | NLE1 | Notchless homolog 1. (487 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (254 aa) |
| | BTG1 | B-cell translocation protein 1. (171 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1090 aa) |
| | LOC102189098 | MPN domain-containing protein. (291 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (442 aa) |
| | MEIOC | Meiosis specific with coiled-coil domain. (960 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (386 aa) |
| | AVEN | Uncharacterized protein. (218 aa) |
| | KNTC1 | Kinetochore associated 1. (2134 aa) |
| | BRINP1 | BMP/retinoic acid inducible neural specific 1. (761 aa) |
| | RAD21 | RAD21 cohesin complex component. (630 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | HASPIN | Histone H3 associated protein kinase. (781 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | ENSCHIP00000006356 | Uncharacterized protein. (101 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1068 aa) |
| | TTK | TTK protein kinase. (852 aa) |
| | RINT1 | RAD50 interactor 1. (792 aa) |
| | BMP7 | Bone morphogenetic protein 7. (431 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1391 aa) |
| | ENSCHIP00000005724 | Uncharacterized protein. (62 aa) |
| | TRIM35 | Tripartite motif containing 35. (493 aa) |
| | NOP53 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (479 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa) |
| | NAE1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (534 aa) |
| | IK | IK cytokine. (530 aa) |
| | PML | Promyelocytic leukemia. (868 aa) |
| | NEK11 | NIMA related kinase 11. (643 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | TREX1 | Three prime repair exonuclease 1. (315 aa) |
| | BTG3 | Uncharacterized protein. (252 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1900 aa) |
| | NACC2 | NACC family member 2. (585 aa) |
| | ENSCHIP00000003493 | MPN domain-containing protein. (262 aa) |
| | GAS1 | Growth arrest specific 1. (348 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa) |
| | FOXN3 | Forkhead box N3. (482 aa) |
| | PSMG2 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa) |
