(17 nodes) Negative regulation of translational initiation network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TPR	Translocated promoter region, nuclear basket protein. (2436 aa)
	LOC108636572	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family. (197 aa)
	C8orf88	Chromosome 8 open reading frame 88. (116 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	PAIP2	Poly(A) binding protein interacting protein 2. (124 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
	EIF4EBP2	Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
	LOC102175844	Uncharacterized protein. (204 aa)
	EIF4EBP3	Eukaryotic translation initiation factor 4E binding protein 3. (102 aa)
	RPL13A	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family. (203 aa)
	PAIP2B	Poly(A) binding protein interacting protein 2B. (138 aa)
	RBM4	RNA binding motif protein 4. (362 aa)
	ENSCHIP00000022448	Uncharacterized protein. (128 aa)
	ENSCHIP00000021691	Uncharacterized protein. (107 aa)
	EIF4EBP1	Uncharacterized protein. (118 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (771 aa)
	LARP1	La ribonucleoprotein domain family member 1. (1144 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	RBM4	ENSCHIP00000006557	ENSCHIP00000022762	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RNA binding motif protein 4.	0.478
EIF2S1	EIF4EBP1	ENSCHIP00000007635	ENSCHIP00000020433	Eukaryotic translation initiation factor 2 subunit alpha.	Uncharacterized protein.	0.456
EIF2S1	ENSCHIP00000021691	ENSCHIP00000007635	ENSCHIP00000021691	Eukaryotic translation initiation factor 2 subunit alpha.	Uncharacterized protein.	0.518
EIF2S1	ENSCHIP00000022448	ENSCHIP00000007635	ENSCHIP00000022448	Eukaryotic translation initiation factor 2 subunit alpha.	Uncharacterized protein.	0.518
EIF2S1	LOC102175844	ENSCHIP00000007635	ENSCHIP00000033535	Eukaryotic translation initiation factor 2 subunit alpha.	Uncharacterized protein.	0.518
EIF2S1	LOC108636572	ENSCHIP00000007635	ENSCHIP00000009869	Eukaryotic translation initiation factor 2 subunit alpha.	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family.	0.518
EIF2S1	RPL13A	ENSCHIP00000007635	ENSCHIP00000024652	Eukaryotic translation initiation factor 2 subunit alpha.	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family.	0.518
EIF4EBP1	EIF2S1	ENSCHIP00000020433	ENSCHIP00000007635	Uncharacterized protein.	Eukaryotic translation initiation factor 2 subunit alpha.	0.456
EIF4EBP1	EIF4EBP2	ENSCHIP00000020433	ENSCHIP00000000591	Uncharacterized protein.	Eukaryotic translation initiation factor 4E binding protein 2.	0.906
EIF4EBP1	EIF4EBP3	ENSCHIP00000020433	ENSCHIP00000032774	Uncharacterized protein.	Eukaryotic translation initiation factor 4E binding protein 3.	0.907
EIF4EBP2	EIF4EBP1	ENSCHIP00000000591	ENSCHIP00000020433	Eukaryotic translation initiation factor 4E binding protein 2.	Uncharacterized protein.	0.906
EIF4EBP2	EIF4EBP3	ENSCHIP00000000591	ENSCHIP00000032774	Eukaryotic translation initiation factor 4E binding protein 2.	Eukaryotic translation initiation factor 4E binding protein 3.	0.904
EIF4EBP3	EIF4EBP1	ENSCHIP00000032774	ENSCHIP00000020433	Eukaryotic translation initiation factor 4E binding protein 3.	Uncharacterized protein.	0.907
EIF4EBP3	EIF4EBP2	ENSCHIP00000032774	ENSCHIP00000000591	Eukaryotic translation initiation factor 4E binding protein 3.	Eukaryotic translation initiation factor 4E binding protein 2.	0.904
ENSCHIP00000021691	EIF2S1	ENSCHIP00000021691	ENSCHIP00000007635	Uncharacterized protein.	Eukaryotic translation initiation factor 2 subunit alpha.	0.518
ENSCHIP00000021691	ENSCHIP00000022448	ENSCHIP00000021691	ENSCHIP00000022448	Uncharacterized protein.	Uncharacterized protein.	0.413
ENSCHIP00000022448	EIF2S1	ENSCHIP00000022448	ENSCHIP00000007635	Uncharacterized protein.	Eukaryotic translation initiation factor 2 subunit alpha.	0.518
ENSCHIP00000022448	ENSCHIP00000021691	ENSCHIP00000022448	ENSCHIP00000021691	Uncharacterized protein.	Uncharacterized protein.	0.413
LOC102175844	EIF2S1	ENSCHIP00000033535	ENSCHIP00000007635	Uncharacterized protein.	Eukaryotic translation initiation factor 2 subunit alpha.	0.518
LOC108636572	EIF2S1	ENSCHIP00000009869	ENSCHIP00000007635	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family.	Eukaryotic translation initiation factor 2 subunit alpha.	0.518