(13 nodes) Purine ribonucleoside biosynthetic process network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADA2	Adenosine deaminase 2. (513 aa)
	HPRT1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	PGM2	Phosphoglucomutase 2. (629 aa)
	MTAP	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (283 aa)
	ADA	Adenosine deaminase. (400 aa)
	ENSCHIP00000026638	Uncharacterized protein. (190 aa)
	PRTFDC1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
	ADAL	Adenosine deaminase like. (352 aa)
	ADK	Adenosine kinase. (362 aa)
	LOC102176691	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	APRT	Adenine phosphoribosyltransferase. (180 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	ADA2	ENSCHIP00000033539	ENSCHIP00000016618	Adenosine deaminase.	Adenosine deaminase 2.	0.940
ADA	ADK	ENSCHIP00000033539	ENSCHIP00000000140	Adenosine deaminase.	Adenosine kinase.	0.993
ADA	APRT	ENSCHIP00000033539	ENSCHIP00000019564	Adenosine deaminase.	Adenine phosphoribosyltransferase.	0.866
ADA	ENSCHIP00000026638	ENSCHIP00000033539	ENSCHIP00000026638	Adenosine deaminase.	Uncharacterized protein.	0.439
ADA	HPRT1	ENSCHIP00000033539	ENSCHIP00000014909	Adenosine deaminase.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.499
ADA	LOC102176691	ENSCHIP00000033539	ENSCHIP00000006635	Adenosine deaminase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.988
ADA	MTAP	ENSCHIP00000033539	ENSCHIP00000013202	Adenosine deaminase.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.521
ADA	NT5E	ENSCHIP00000033539	ENSCHIP00000007021	Adenosine deaminase.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.968
ADA	PNP	ENSCHIP00000033539	ENSCHIP00000008961	Adenosine deaminase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.988
ADA	PRTFDC1	ENSCHIP00000033539	ENSCHIP00000020785	Adenosine deaminase.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.493
ADA2	ADA	ENSCHIP00000016618	ENSCHIP00000033539	Adenosine deaminase 2.	Adenosine deaminase.	0.940
ADA2	ADK	ENSCHIP00000016618	ENSCHIP00000000140	Adenosine deaminase 2.	Adenosine kinase.	0.959
ADA2	APRT	ENSCHIP00000016618	ENSCHIP00000019564	Adenosine deaminase 2.	Adenine phosphoribosyltransferase.	0.763
ADA2	ENSCHIP00000026638	ENSCHIP00000016618	ENSCHIP00000026638	Adenosine deaminase 2.	Uncharacterized protein.	0.439
ADA2	HPRT1	ENSCHIP00000016618	ENSCHIP00000014909	Adenosine deaminase 2.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.439
ADA2	LOC102176691	ENSCHIP00000016618	ENSCHIP00000006635	Adenosine deaminase 2.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.954
ADA2	MTAP	ENSCHIP00000016618	ENSCHIP00000013202	Adenosine deaminase 2.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.518
ADA2	NT5E	ENSCHIP00000016618	ENSCHIP00000007021	Adenosine deaminase 2.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.957
ADA2	PNP	ENSCHIP00000016618	ENSCHIP00000008961	Adenosine deaminase 2.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.954
ADA2	PRTFDC1	ENSCHIP00000016618	ENSCHIP00000020785	Adenosine deaminase 2.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.439