STRINGSTRING
ENSCHIP00000029680 ENSCHIP00000029680 BMPR1A BMPR1A LOC102191748 LOC102191748 KIF18A KIF18A KDM5A KDM5A FANCA FANCA LOC108633554 LOC108633554 HOXA9 HOXA9 PDGFRA PDGFRA PLEKHA1 PLEKHA1 CRKL CRKL LHCGR LHCGR LOC102182848 LOC102182848 NHLH2 NHLH2 LOC108636012 LOC108636012 RXFP2 RXFP2 HOXA13 HOXA13 LRRC6 LRRC6 GATA1 GATA1 WNT2B WNT2B WDR48 WDR48 ADAM21 ADAM21 GATA4 GATA4 DHH DHH HOXD13 HOXD13 LOC108633916 LOC108633916 NKX3-1 NKX3-1 ASB1 ASB1 YBX3 YBX3 LOC102171353 LOC102171353 LOC108633166 LOC108633166 ING2 ING2 NHLH1 NHLH1 SIX4 SIX4 TBX3 TBX3 HSD17B4 HSD17B4 BCL2L2 BCL2L2 TMF1 TMF1 FGF10 FGF10 DMRT3 DMRT3 WT1 WT1 SYCP2 SYCP2 ATN1 ATN1 NR0B1 NR0B1 ATRX ATRX ESR1 ESR1 SGPL1 SGPL1 LHFPL2 LHFPL2 SFRP1 SFRP1 RARA RARA TCF21 TCF21 REN REN BRIP1 BRIP1 WNT5A WNT5A TFAP2C TFAP2C BCL2 BCL2 TBC1D20 TBC1D20 SOX8 SOX8 FGF8 FGF8 KLHL10 KLHL10 NUPR1 NUPR1 GREB1 GREB1 CSMD2 CSMD2 LHX9 LHX9 GATA6 GATA6 LRP2 LRP2 CSMD1 CSMD1 SMAD4 SMAD4 ARID5B ARID5B NR5A1 NR5A1 ADGRG1 ADGRG1 REC8 REC8 BCL2L11 BCL2L11 PATZ1 PATZ1 HOXA11 HOXA11 FGF9 FGF9 AR AR ARID4A ARID4A ENSCHIP00000024414 ENSCHIP00000024414 SOX9 SOX9 LOC102177554 LOC102177554 STAT5B STAT5B LOC102189503 LOC102189503 MSH2 MSH2 RAD21L1 RAD21L1 RAB13 RAB13 KIT KIT TGFBR1 TGFBR1 PRDX4 PRDX4 COL9A3 COL9A3 SFRP2 SFRP2 SCAPER SCAPER LOC102190909 LOC102190909 FSHR FSHR SHH SHH NKX2-1 NKX2-1 DMRT1 DMRT1 AMH AMH SAFB2 SAFB2 GATA3 GATA3 KITLG KITLG CTNNB1 CTNNB1 DHCR24 DHCR24 ERCC1 ERCC1 SRD5A2 SRD5A2 SF1 SF1 INHBA INHBA GREB1L GREB1L EIF2S2 EIF2S2 BMP6 BMP6 AGO4 AGO4 ADAM20 ADAM20 WNT9B WNT9B HSD17B3 HSD17B3 LGR4 LGR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000029680Uncharacterized protein. (789 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC102191748Histone domain-containing protein. (136 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (893 aa)
KDM5ALysine demethylase 5A. (1690 aa)
FANCAFA complementation group A. (1416 aa)
LOC108633554Histone domain-containing protein. (136 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (279 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
NHLH2Nescient helix-loop-helix 2. (133 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
RXFP2Relaxin family peptide receptor 2. (725 aa)
HOXA13Homeobox A13. (388 aa)
LRRC6Leucine rich repeat containing 6. (474 aa)
GATA1GATA binding protein 1. (413 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
WDR48WD repeat domain 48. (678 aa)
ADAM21ADAM metallopeptidase domain 21. (719 aa)
GATA4GATA binding protein 4. (442 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
HOXD13Homeobox D13. (340 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
NKX3-1NK3 homeobox 1. (239 aa)
ASB1Ankyrin repeat and SOCS box containing 1. (332 aa)
YBX3Y-box binding protein 3. (376 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633166eIF2B_5 domain-containing protein. (333 aa)
ING2Inhibitor of growth protein. (283 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
SIX4SIX homeobox 4. (784 aa)
TBX3T-box transcription factor 3. (749 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (736 aa)
BCL2L2BCL2 like 2. (193 aa)
TMF1TATA element modulatory factor 1. (1089 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
WT1WT1 transcription factor. (450 aa)
SYCP2Synaptonemal complex protein 2. (1456 aa)
ATN1Atrophin 1. (1207 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
ATRXATRX chromatin remodeler. (2105 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
LHFPL2LHFPL tetraspan subfamily member 2. (228 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
RARARetinoic acid receptor alpha. (462 aa)
TCF21Transcription factor 21. (179 aa)
RENRenin; Belongs to the peptidase A1 family. (403 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
TFAP2CTranscription factor AP-2 gamma. (450 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
SOX8SRY-box transcription factor 8. (534 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
KLHL10Kelch like family member 10. (599 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
GREB1Uncharacterized protein. (1944 aa)
CSMD2CUB and Sushi multiple domains 2. (3313 aa)
LHX9LIM homeobox 9. (397 aa)
GATA6GATA binding protein 6. (592 aa)
LRP2LDL receptor related protein 2. (4649 aa)
CSMD1CUB and Sushi multiple domains 1. (3068 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
ARID5BAT-rich interaction domain 5B. (1187 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (686 aa)
REC8REC8 meiotic recombination protein. (564 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
HOXA11Homeobox A11. (317 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ARAndrogen receptor. (891 aa)
ARID4AAT-rich interaction domain 4A. (1257 aa)
ENSCHIP00000024414Uncharacterized protein. (57 aa)
SOX9SRY-box transcription factor 9. (525 aa)
LOC102177554Uncharacterized protein. (798 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
RAD21L1RAD21 cohesin complex component like 1. (554 aa)
RAB13Uncharacterized protein. (203 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
PRDX4Peroxiredoxin 4. (275 aa)
COL9A3Uncharacterized protein. (392 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1400 aa)
LOC102190909Histone H3.3. (136 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (670 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
NKX2-1NK2 homeobox 1. (370 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
AMHAnti-Mullerian hormone. (575 aa)
SAFB2Scaffold attachment factor B2. (942 aa)
GATA3GATA binding protein 3. (467 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
CTNNB1Catenin beta 1. (781 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
SF1Splicing factor 1. (639 aa)
INHBAInhibin beta A subunit. (425 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1911 aa)
EIF2S2eIF2B_5 domain-containing protein. (340 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (875 aa)
ADAM20ADAM metallopeptidase domain 20. (731 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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