(42 nodes) Positive regulation of fibroblast proliferation network (Capra hircus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ENSCHIP00000000380	Uncharacterized protein. (305 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1072 aa)
	EREG	Epiregulin. (163 aa)
	LIG4	DNA ligase. (911 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	CD248	CD248 molecule. (773 aa)
	ENSCHIP00000003472	Uncharacterized protein. (75 aa)
	PML	Promyelocytic leukemia. (868 aa)
	FOSL2	FOS like 2, AP-1 transcription factor subunit. (327 aa)
	PLA2G1B	Phospholipase A(2). (145 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	WAPL	WAPL cohesin release factor. (1193 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	CD74	CD74 molecule. (261 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	GAS6	Growth arrest specific 6. (671 aa)
	E2F1	E2F transcription factor 1. (441 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	BMI1	RING-type domain-containing protein. (437 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	DHX9	DExH-box helicase 9. (1271 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	BRK1	Uncharacterized protein. (75 aa)
	FBRS	Uncharacterized protein. (461 aa)
	SPHK1	Sphingosine kinase 1. (392 aa)
	FN1	Fibronectin 1. (2478 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (889 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)
	CTC1	CST telomere replication complex component 1. (1210 aa)
	NDUFS4	NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMI1	CDK6	ENSCHIP00000016491	ENSCHIP00000008415	RING-type domain-containing protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.419
BMI1	E2F1	ENSCHIP00000016491	ENSCHIP00000014803	RING-type domain-containing protein.	E2F transcription factor 1.	0.497
BMI1	MYC	ENSCHIP00000016491	ENSCHIP00000011576	RING-type domain-containing protein.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.554
CD248	PDGFB	ENSCHIP00000002817	ENSCHIP00000031260	CD248 molecule.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.400
CD248	PDGFRA	ENSCHIP00000002817	ENSCHIP00000002297	CD248 molecule.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.471
CDK6	BMI1	ENSCHIP00000008415	ENSCHIP00000016491	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	RING-type domain-containing protein.	0.419
CDK6	CDKN1A	ENSCHIP00000008415	ENSCHIP00000002564	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.998
CDK6	E2F1	ENSCHIP00000008415	ENSCHIP00000014803	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	E2F transcription factor 1.	0.863
CDK6	ESR1	ENSCHIP00000008415	ENSCHIP00000012243	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.621
CDK6	FBRS	ENSCHIP00000008415	ENSCHIP00000024506	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.453
CDK6	JUN	ENSCHIP00000008415	ENSCHIP00000001903	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.507
CDK6	MYC	ENSCHIP00000008415	ENSCHIP00000011576	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.527
CDKN1A	CDK6	ENSCHIP00000002564	ENSCHIP00000008415	Cyclin dependent kinase inhibitor 1A.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.998
CDKN1A	E2F1	ENSCHIP00000002564	ENSCHIP00000014803	Cyclin dependent kinase inhibitor 1A.	E2F transcription factor 1.	0.794
CDKN1A	ESR1	ENSCHIP00000002564	ENSCHIP00000012243	Cyclin dependent kinase inhibitor 1A.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.619
CDKN1A	JUN	ENSCHIP00000002564	ENSCHIP00000001903	Cyclin dependent kinase inhibitor 1A.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.570
CDKN1A	MYC	ENSCHIP00000002564	ENSCHIP00000011576	Cyclin dependent kinase inhibitor 1A.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.653
CDKN1A	PDGFRA	ENSCHIP00000002564	ENSCHIP00000002297	Cyclin dependent kinase inhibitor 1A.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.470
E2F1	BMI1	ENSCHIP00000014803	ENSCHIP00000016491	E2F transcription factor 1.	RING-type domain-containing protein.	0.497
E2F1	CDK6	ENSCHIP00000014803	ENSCHIP00000008415	E2F transcription factor 1.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.863