(10 nodes) Paraxial mesoderm morphogenesis network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	HNF1A	HNF1 homeobox A. (631 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	EXOC4	Uncharacterized protein. (408 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	ENSCHIP00000019018	Sec8_exocyst domain-containing protein. (413 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPR1A	LEF1	ENSCHIP00000000640	ENSCHIP00000030629	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	HMG box domain-containing protein.	0.648
BMPR1A	SMAD2	ENSCHIP00000000640	ENSCHIP00000022106	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.978
BMPR1A	SMAD3	ENSCHIP00000000640	ENSCHIP00000011729	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.971
BMPR1A	WNT3A	ENSCHIP00000000640	ENSCHIP00000015590	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.433
BMPR1A	WNT5A	ENSCHIP00000000640	ENSCHIP00000015533	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.432
ENSCHIP00000019018	EXOC4	ENSCHIP00000019018	ENSCHIP00000028518	Sec8_exocyst domain-containing protein.	Uncharacterized protein.	0.921
EXOC4	ENSCHIP00000019018	ENSCHIP00000028518	ENSCHIP00000019018	Uncharacterized protein.	Sec8_exocyst domain-containing protein.	0.921
LEF1	BMPR1A	ENSCHIP00000030629	ENSCHIP00000000640	HMG box domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.648
LEF1	SMAD2	ENSCHIP00000030629	ENSCHIP00000022106	HMG box domain-containing protein.	Mothers against decapentaplegic homolog.	0.657
LEF1	SMAD3	ENSCHIP00000030629	ENSCHIP00000011729	HMG box domain-containing protein.	Mothers against decapentaplegic homolog.	0.799
LEF1	WNT11	ENSCHIP00000030629	ENSCHIP00000024696	HMG box domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.721
LEF1	WNT3A	ENSCHIP00000030629	ENSCHIP00000015590	HMG box domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.831
LEF1	WNT5A	ENSCHIP00000030629	ENSCHIP00000015533	HMG box domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.789
SMAD2	BMPR1A	ENSCHIP00000022106	ENSCHIP00000000640	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.978
SMAD2	LEF1	ENSCHIP00000022106	ENSCHIP00000030629	Mothers against decapentaplegic homolog.	HMG box domain-containing protein.	0.657
SMAD2	SMAD3	ENSCHIP00000022106	ENSCHIP00000011729	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.999
SMAD2	WNT3A	ENSCHIP00000022106	ENSCHIP00000015590	Mothers against decapentaplegic homolog.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.560
SMAD3	BMPR1A	ENSCHIP00000011729	ENSCHIP00000000640	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.971
SMAD3	LEF1	ENSCHIP00000011729	ENSCHIP00000030629	Mothers against decapentaplegic homolog.	HMG box domain-containing protein.	0.799
SMAD3	SMAD2	ENSCHIP00000011729	ENSCHIP00000022106	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.999