(31 nodes) Spleen development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CACNB4	SH3 domain-containing protein. (505 aa)
	RBM15	RNA binding motif protein 15. (962 aa)
	HOXB4	Homeobox B4. (251 aa)
	BARX1	BARX homeobox 1. (254 aa)
	ONECUT1	One cut domain family member. (464 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1189 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (572 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (900 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
	ABL1	Tyrosine-protein kinase. (1151 aa)
	FLVCR1	Feline leukemia virus subgroup C cellular receptor 1. (556 aa)
	CTC1	CST telomere replication complex component 1. (1210 aa)
	PCID2	PCI domain containing 2. (393 aa)
	ENSCHIP00000000670	DNA_pol_B_thumb domain-containing protein. (54 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1258 aa)
	SAMD9	Sterile alpha motif domain containing 9. (1581 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
	PKN1	Protein kinase N1. (950 aa)
	NKX3-2	NK3 homeobox 2. (330 aa)
	CDH17	Cadherin 17. (832 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (453 aa)
	TCF21	Transcription factor 21. (179 aa)
	BCL3	BCL3 transcription coactivator. (454 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	RIPK3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (243 aa)
	KMT2A	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3871 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	NKX2-3	NK2 homeobox 3. (367 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	KMT2A	ENSCHIP00000024651	ENSCHIP00000017658	Tyrosine-protein kinase.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	0.422
BARX1	FGF10	ENSCHIP00000018825	ENSCHIP00000010028	BARX homeobox 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.423
BARX1	NKX3-2	ENSCHIP00000018825	ENSCHIP00000007698	BARX homeobox 1.	NK3 homeobox 2.	0.420
BCL2	BCL2L11	ENSCHIP00000015831	ENSCHIP00000022113	BH4_2 domain-containing protein.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.997
BCL2	FADD	ENSCHIP00000015831	ENSCHIP00000004023	BH4_2 domain-containing protein.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.794
BCL2	PPP2R3C	ENSCHIP00000015831	ENSCHIP00000013768	BH4_2 domain-containing protein.	Protein phosphatase 2 regulatory subunit B''gamma.	0.900
BCL2	RIPK3	ENSCHIP00000015831	ENSCHIP00000016204	BH4_2 domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.488
BCL2L11	BCL2	ENSCHIP00000022113	ENSCHIP00000015831	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	BH4_2 domain-containing protein.	0.997
BCL3	NFKB2	ENSCHIP00000015746	ENSCHIP00000021741	BCL3 transcription coactivator.	Nuclear factor kappa B subunit 2.	0.789
FADD	BCL2	ENSCHIP00000004023	ENSCHIP00000015831	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	BH4_2 domain-containing protein.	0.794
FADD	RIPK3	ENSCHIP00000004023	ENSCHIP00000016204	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
FGF10	BARX1	ENSCHIP00000010028	ENSCHIP00000018825	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	BARX homeobox 1.	0.423
FGF10	NKX2-5	ENSCHIP00000010028	ENSCHIP00000017688	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NK2 homeobox 5.	0.478
KMT2A	ABL1	ENSCHIP00000017658	ENSCHIP00000024651	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	Tyrosine-protein kinase.	0.422
NFKB2	BCL3	ENSCHIP00000021741	ENSCHIP00000015746	Nuclear factor kappa B subunit 2.	BCL3 transcription coactivator.	0.789
NKX2-5	FGF10	ENSCHIP00000017688	ENSCHIP00000010028	NK2 homeobox 5.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
NKX2-5	TCF21	ENSCHIP00000017688	ENSCHIP00000014722	NK2 homeobox 5.	Transcription factor 21.	0.473
NKX3-2	BARX1	ENSCHIP00000007698	ENSCHIP00000018825	NK3 homeobox 2.	BARX homeobox 1.	0.420
PPP2R3C	BCL2	ENSCHIP00000013768	ENSCHIP00000015831	Protein phosphatase 2 regulatory subunit B''gamma.	BH4_2 domain-containing protein.	0.900
RC3H1	RC3H2	ENSCHIP00000001488	ENSCHIP00000020775	Ring finger and CCCH-type domains 1.	Ring finger and CCCH-type domains 2.	0.586