STRINGSTRING
TP63 TP63 VPS52 VPS52 SHH SHH PRDM1 PRDM1 NKX2-6 NKX2-6 SMO SMO SFRP2 SFRP2 COBL COBL TGFB2 TGFB2 KIT KIT WNT11 WNT11 ZIC3 ZIC3 SOX9 SOX9 MYOCD MYOCD NOTCH1 NOTCH1 BMP4 BMP4 SOX17 SOX17 ENSCHIP00000023179 ENSCHIP00000023179 KCNQ1 KCNQ1 FGF9 FGF9 STRA6 STRA6 FOXF2 FOXF2 SMAD2 SMAD2 CXCL8 CXCL8 SOX10 SOX10 YIPF6 YIPF6 FOXF1 FOXF1 GATA6 GATA6 ID2 ID2 HES1 HES1 NKX2-3 NKX2-3 MIXL1 MIXL1 YAP1 YAP1 SPDEF SPDEF IHH IHH PKD1 PKD1 BCL2 BCL2 PDX1 PDX1 WNT5A WNT5A SHOX2 SHOX2 HNF1B HNF1B PDGFC PDGFC FAT4 FAT4 NPHP3 NPHP3 HIF1A HIF1A TCF21 TCF21 CCDC103 CCDC103 GLI3 GLI3 MEGF8 MEGF8 GATA5 GATA5 TBX2 TBX2 SFRP1 SFRP1 HLX HLX EPB41L5 EPB41L5 SMAD3 SMAD3 ASCL1 ASCL1 DCHS1 DCHS1 SAV1 SAV1 FGF10 FGF10 KLF5 KLF5 AGR2 AGR2 RARB RARB GRP GRP EDNRB EDNRB PKDCC PKDCC NIPBL NIPBL NKX3-2 NKX3-2 CLMP CLMP SIX2 SIX2 ALX4 ALX4 RARRES2 RARRES2 TIGAR TIGAR GATA4 GATA4 ENSCHIP00000005279 ENSCHIP00000005279 EXT1 EXT1 ENSCHIP00000005210 ENSCHIP00000005210 TNF TNF IL6ST IL6ST FZD5 FZD5 DNAAF1 DNAAF1 ENSCHIP00000003193 ENSCHIP00000003193 CRKL CRKL CCDC40 CCDC40 SRC SRC FOXE1 FOXE1 EPHB3 EPHB3 HOXA5 HOXA5 PDGFRA PDGFRA PCSK5 PCSK5 RB1 RB1 FOXL1 FOXL1 NODAL NODAL LGR4 LGR4 ADA ADA CHD8 CHD8 SALL1 SALL1 ALDH1A2 ALDH1A2 CTNNB1 CTNNB1 CCDC39 CCDC39 AHI1 AHI1 PTK6 PTK6 C1GALT1 C1GALT1 NKX2-2 NKX2-2 CDX2 CDX2 CLDN18 CLDN18 RBPMS2 RBPMS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
VPS52VPS52 subunit of GARP complex. (725 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
PRDM1PR/SET domain 1. (851 aa)
NKX2-6NK2 homeobox 6. (300 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
COBLCordon-bleu WH2 repeat protein. (1321 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ZIC3Zic family member 3. (465 aa)
SOX9SRY-box transcription factor 9. (525 aa)
MYOCDMyocardin. (982 aa)
NOTCH1Notch receptor 1. (2508 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SOX17SRY-box transcription factor 17. (410 aa)
ENSCHIP00000023179Uncharacterized protein. (330 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (670 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
STRA6Stimulated by retinoic acid 6. (654 aa)
FOXF2Forkhead box F2. (437 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SOX10SRY-box transcription factor 10. (469 aa)
YIPF6Protein YIPF. (236 aa)
FOXF1Forkhead box F1. (391 aa)
GATA6GATA binding protein 6. (592 aa)
ID2BHLH domain-containing protein. (134 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NKX2-3NK2 homeobox 3. (367 aa)
MIXL1Mix paired-like homeobox. (233 aa)
YAP1Yes associated protein 1. (503 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (330 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
PDX1Pancreatic and duodenal homeobox 1. (284 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
SHOX2Short stature homeobox 2. (319 aa)
HNF1BHNF1 homeobox B. (558 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
FAT4FAT atypical cadherin 4. (4982 aa)
NPHP3TPR_REGION domain-containing protein. (1325 aa)
HIF1AUncharacterized protein. (823 aa)
TCF21Transcription factor 21. (179 aa)
CCDC103Coiled-coil domain containing 103. (235 aa)
GLI3GLI family zinc finger 3. (1614 aa)
MEGF8Multiple EGF like domains 8. (2836 aa)
GATA5GATA binding protein 5. (403 aa)
TBX2T-box transcription factor 2. (771 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
HLXH2.0 like homeobox. (488 aa)
EPB41L5FERM domain-containing protein. (505 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
DCHS1Dachsous cadherin-related 1. (3258 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
KLF5Uncharacterized protein. (454 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
RARBRetinoic acid receptor beta. (448 aa)
GRPGastrin releasing peptide. (159 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
NIPBLNipped-B protein. (2804 aa)
NKX3-2NK3 homeobox 2. (330 aa)
CLMPCXADR like membrane protein. (373 aa)
SIX2SIX homeobox 2. (296 aa)
ALX4ALX homeobox 4. (397 aa)
RARRES2Chemerin. (162 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
GATA4GATA binding protein 4. (442 aa)
ENSCHIP00000005279RRM domain-containing protein. (80 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
ENSCHIP00000005210Uncharacterized protein. (237 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
DNAAF1Dynein assembly factor 1, axonemal. (643 aa)
ENSCHIP00000003193BHLH domain-containing protein. (122 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
CCDC40Coiled-coil domain containing 40. (937 aa)
SRCTyrosine-protein kinase. (538 aa)
FOXE1Forkhead box E1. (373 aa)
EPHB3EPH receptor B3. (999 aa)
HOXA5Homeobox A5. (270 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1884 aa)
RB1RB transcriptional corepressor 1. (931 aa)
FOXL1Forkhead box L1. (346 aa)
NODALNodal growth differentiation factor. (346 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
ADAAdenosine deaminase. (400 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
SALL1Spalt like transcription factor 1. (1317 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
CTNNB1Catenin beta 1. (781 aa)
CCDC39Coiled-coil domain containing 39. (931 aa)
AHI1Abelson helper integration site 1. (1194 aa)
PTK6Tyrosine-protein kinase. (450 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (372 aa)
NKX2-2NK2 homeobox 2. (273 aa)
CDX2Caudal type homeobox 2. (306 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (197 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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