(81 nodes) Developmental cell growth network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	LIMK1	LIM domain kinase 1. (647 aa)
	ARIH2	RBR-type E3 ubiquitin transferase. (491 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	CPNE1	Copine 1. (537 aa)
	SLIT2	Slit guidance ligand 2. (1457 aa)
	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1256 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SEMA7A	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
	LOC102177760	Plexin A1. (1661 aa)
	SPAG6	Sperm associated antigen 6. (509 aa)
	LHX2	Uncharacterized protein. (422 aa)
	SPART	Spartin. (668 aa)
	NIN	Ninein. (2137 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
	EDN2	Endothelin 2. (177 aa)
	ALCAM	Activated leukocyte cell adhesion molecule. (583 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	NRN1	Neuritin 1. (142 aa)
	RYK	Receptor like tyrosine kinase. (609 aa)
	DCLK1	Doublecortin like kinase 1. (741 aa)
	COBL	Cordon-bleu WH2 repeat protein. (1321 aa)
	PLXNA3	Plexin A3. (1822 aa)
	USP9X	Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2570 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (764 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	NDEL1	NudE neurodevelopment protein 1 like 1. (345 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	DDR1	Tyrosine-protein kinase receptor. (915 aa)
	SEMA5B	Semaphorin 5B. (1043 aa)
	ADRA1A	Adrenoceptor alpha 1A. (466 aa)
	SHBG	Sex hormone binding globulin. (405 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	LLPH	LLP homolog, long-term synaptic facilitation factor. (127 aa)
	ULK1	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1055 aa)
	POU4F3	POU domain protein. (338 aa)
	MEX3C	Mex-3 RNA binding family member C. (664 aa)
	LPAR3	Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1268 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2432 aa)
	SSNA1	SS nuclear autoantigen 1. (119 aa)
	AUTS2	Activator of transcription and developmental regulator AUTS2. (1098 aa)
	TNN	Tenascin N. (1384 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	LAMB2	Laminin subunit beta 2. (1802 aa)
	DVL1	Dishevelled segment polarity protein 1. (682 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (481 aa)
	LOC108634550	USP domain-containing protein; Belongs to the peptidase C19 family. (2572 aa)
	NRN1L	Neuritin 1 like. (171 aa)
	MAP1B	Microtubule associated protein 1B. (2468 aa)
	SEMA5A	Semaphorin 5A. (1073 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (205 aa)
	JADE2	Jade family PHD finger 2. (861 aa)
	POU4F2	POU domain protein. (408 aa)
	PLXNA1	Plexin_cytopl domain-containing protein. (255 aa)
	WASF1	WASP family member 1. (570 aa)
	SRF	Serum response factor. (509 aa)
	EDN1	Endothelin 1. (202 aa)
	EMX1	Empty spiracles homeobox 1. (288 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	SLIT1	Slit guidance ligand 1. (1534 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	HDAC6	Histone deacetylase 6. (988 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
	TNR	Tenascin R. (1358 aa)
	CDKL3	Cyclin dependent kinase like 3. (717 aa)
	NDN	Necdin, MAGE family member. (325 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	CYFIP2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
	GDF9	Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
	CDH4	Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (903 aa)
	SLIT3	Slit guidance ligand 3. (1320 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
	IST1	IST1 factor associated with ESCRT-III. (364 aa)
	LOC108635284	Uncharacterized protein. (299 aa)
	TMEM108	Transmembrane protein 108. (581 aa)
	VCL	Vinculin. (1134 aa)
	IMPACT	Impact RWD domain protein. (318 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	EDN1	ENSCHIP00000023421	ENSCHIP00000008821	Adrenoceptor alpha 1A.	Endothelin 1.	0.671
ADRA1A	EDN2	ENSCHIP00000023421	ENSCHIP00000028604	Adrenoceptor alpha 1A.	Endothelin 2.	0.659
ALCAM	ITGB1	ENSCHIP00000028594	ENSCHIP00000007508	Activated leukocyte cell adhesion molecule.	Integrin beta; Belongs to the integrin beta chain family.	0.610
APP	BDNF	ENSCHIP00000032622	ENSCHIP00000003028	Amyloid beta precursor protein.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.649
APP	C9orf72	ENSCHIP00000032622	ENSCHIP00000013283	Amyloid beta precursor protein.	C9orf72-SMCR8 complex subunit.	0.489
APP	CTNNB1	ENSCHIP00000032622	ENSCHIP00000031016	Amyloid beta precursor protein.	Catenin beta 1.	0.483
APP	EDN1	ENSCHIP00000032622	ENSCHIP00000008821	Amyloid beta precursor protein.	Endothelin 1.	0.421
APP	ITGB1	ENSCHIP00000032622	ENSCHIP00000007508	Amyloid beta precursor protein.	Integrin beta; Belongs to the integrin beta chain family.	0.536
AURKA	CTNNB1	ENSCHIP00000029258	ENSCHIP00000031016	Aurora kinase A; Belongs to the protein kinase superfamily.	Catenin beta 1.	0.456
AURKA	HDAC6	ENSCHIP00000029258	ENSCHIP00000006126	Aurora kinase A; Belongs to the protein kinase superfamily.	Histone deacetylase 6.	0.619
AURKA	NIN	ENSCHIP00000029258	ENSCHIP00000029370	Aurora kinase A; Belongs to the protein kinase superfamily.	Ninein.	0.442
BDNF	APP	ENSCHIP00000003028	ENSCHIP00000032622	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Amyloid beta precursor protein.	0.649
BDNF	C9orf72	ENSCHIP00000003028	ENSCHIP00000013283	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	C9orf72-SMCR8 complex subunit.	0.604
BDNF	CTNNB1	ENSCHIP00000003028	ENSCHIP00000031016	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Catenin beta 1.	0.551
BDNF	EDN1	ENSCHIP00000003028	ENSCHIP00000008821	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Endothelin 1.	0.424
BDNF	EFNA5	ENSCHIP00000003028	ENSCHIP00000010250	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Ephrin A5; Belongs to the ephrin family.	0.427
BDNF	EMX1	ENSCHIP00000003028	ENSCHIP00000008644	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Empty spiracles homeobox 1.	0.435
BDNF	ITGB1	ENSCHIP00000003028	ENSCHIP00000007508	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Integrin beta; Belongs to the integrin beta chain family.	0.407
BDNF	LIMK1	ENSCHIP00000003028	ENSCHIP00000033612	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	LIM domain kinase 1.	0.446
BDNF	LOC108635284	ENSCHIP00000003028	ENSCHIP00000001298	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Uncharacterized protein.	0.517