82 items (Capra hircus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	CALCRL	Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	RBM10	RNA binding motif protein 10. (921 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (310 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (328 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
	ENSCHIP00000003193	BHLH domain-containing protein. (122 aa)
	CCDC142	Coiled-coil domain containing 142. (725 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	HTR1B	5-hydroxytryptamine receptor 1B. (389 aa)
	ENSCHIP00000005279	RRM domain-containing protein. (80 aa)
	TCF7L2	Transcription factor 7 like 2. (669 aa)
	MEF2D	MADS-box domain-containing protein. (513 aa)
	RNASE4	Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (163 aa)
	NF1	Neurofibromin 1. (2848 aa)
	CDH13	Cadherin 13. (663 aa)
	IGFBP5	Insulin-like growth factor binding protein 5. (272 aa)
	EDN1	Endothelin 1. (202 aa)
	NDRG2	NDRG family member 2. (371 aa)
	PRKG1	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (465 aa)
	IL6R	Interleukin 6 receptor. (441 aa)
	PHB	Prohibitin. (272 aa)
	XRCC6	X-ray repair cross complementing 6. (607 aa)
	BMP2	TGF_BETA_2 domain-containing protein. (381 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
	DBH	Dopamine beta-hydroxylase. (616 aa)
	VIP	Vasoactive intestinal peptide. (170 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	PPARGC1A	RRM domain-containing protein. (797 aa)
	MEF2C	MADS-box domain-containing protein. (441 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	APOD	Apolipoprotein D. (213 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	PTGIR	Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	HMOX1	Heme oxygenase 1. (288 aa)
	MMP9	Uncharacterized protein. (709 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
	THBS1	Thrombospondin 1. (1218 aa)
	FOXP1	Fork-head domain-containing protein. (675 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ID2	BHLH domain-containing protein. (134 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	CNN1	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (648 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FOXJ2	Forkhead box J2. (561 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	MYOCD	Myocardin. (982 aa)
	TRIB1	Tribbles pseudokinase 1. (372 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	NDRG4	NDRG family member 4. (391 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	APOE	Apolipoprotein E. (326 aa)
	XRCC5	X-ray repair cross complementing 5. (736 aa)
	PDCD4	Programmed cell death 4. (513 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (476 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	IGFBP3	Uncharacterized protein. (293 aa)
	RBPMS2	RNA binding protein, mRNA processing factor 2. (197 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (267 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (955 aa)
	ENSCHIP00000032320	Prohibitin. (189 aa)
	ADIPOQ	C1q domain-containing protein. (283 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS1	EDN1	ENSCHIP00000002973	ENSCHIP00000008821	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Endothelin 1.	0.446
ADAMTS1	HBEGF	ENSCHIP00000002973	ENSCHIP00000026288	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Heparin binding EGF like growth factor.	0.557
ADAMTS1	MMP9	ENSCHIP00000002973	ENSCHIP00000016938	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Uncharacterized protein.	0.487
ADAMTS1	THBS1	ENSCHIP00000002973	ENSCHIP00000018114	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Thrombospondin 1.	0.422
ADIPOQ	AKT1	ENSCHIP00000032803	ENSCHIP00000027335	C1q domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.433
ADIPOQ	APOE	ENSCHIP00000032803	ENSCHIP00000025098	C1q domain-containing protein.	Apolipoprotein E.	0.659
ADIPOQ	CDH13	ENSCHIP00000032803	ENSCHIP00000007913	C1q domain-containing protein.	Cadherin 13.	0.570
ADIPOQ	CTNNB1	ENSCHIP00000032803	ENSCHIP00000031016	C1q domain-containing protein.	Catenin beta 1.	0.424
ADIPOQ	HMOX1	ENSCHIP00000032803	ENSCHIP00000016460	C1q domain-containing protein.	Heme oxygenase 1.	0.437
ADIPOQ	IFNG	ENSCHIP00000032803	ENSCHIP00000016152	C1q domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.501
ADIPOQ	IGF1	ENSCHIP00000032803	ENSCHIP00000020185	C1q domain-containing protein.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.702
ADIPOQ	MMP9	ENSCHIP00000032803	ENSCHIP00000016938	C1q domain-containing protein.	Uncharacterized protein.	0.420
ADIPOQ	PPARGC1A	ENSCHIP00000032803	ENSCHIP00000015380	C1q domain-containing protein.	RRM domain-containing protein.	0.732
ADIPOQ	TLR4	ENSCHIP00000032803	ENSCHIP00000019512	C1q domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.530
ADIPOQ	TNF	ENSCHIP00000032803	ENSCHIP00000004561	C1q domain-containing protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.762
AIF1	TLR4	ENSCHIP00000028430	ENSCHIP00000019512	Allograft inflammatory factor 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.407
AIF1	TNF	ENSCHIP00000028430	ENSCHIP00000004561	Allograft inflammatory factor 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.496
AKT1	ADIPOQ	ENSCHIP00000027335	ENSCHIP00000032803	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	C1q domain-containing protein.	0.433
AKT1	CDKN1A	ENSCHIP00000027335	ENSCHIP00000002564	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.969
AKT1	CDKN1B	ENSCHIP00000027335	ENSCHIP00000015316	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.962