(47 nodes) Positive regulation of smooth muscle cell proliferation network (Capra hircus)

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Predicted Interactions

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Your Input:
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (310 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (328 aa)
	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
	ENSCHIP00000003193	BHLH domain-containing protein. (122 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	HTR1B	5-hydroxytryptamine receptor 1B. (389 aa)
	ENSCHIP00000005279	RRM domain-containing protein. (80 aa)
	MEF2D	MADS-box domain-containing protein. (513 aa)
	NF1	Neurofibromin 1. (2848 aa)
	CDH13	Cadherin 13. (663 aa)
	IGFBP5	Insulin-like growth factor binding protein 5. (272 aa)
	EDN1	Endothelin 1. (202 aa)
	CALCRL	Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
	IL6R	Interleukin 6 receptor. (441 aa)
	PHB	Prohibitin. (272 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	HMOX1	Heme oxygenase 1. (288 aa)
	MMP9	Uncharacterized protein. (709 aa)
	THBS1	Thrombospondin 1. (1218 aa)
	FOXP1	Fork-head domain-containing protein. (675 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ID2	BHLH domain-containing protein. (134 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (648 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FOXJ2	Forkhead box J2. (561 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (476 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	RBPMS2	RNA binding protein, mRNA processing factor 2. (197 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (267 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (955 aa)
	ENSCHIP00000032320	Prohibitin. (189 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS1	EDN1	ENSCHIP00000002973	ENSCHIP00000008821	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Endothelin 1.	0.446
ADAMTS1	HBEGF	ENSCHIP00000002973	ENSCHIP00000026288	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Heparin binding EGF like growth factor.	0.557
ADAMTS1	MMP9	ENSCHIP00000002973	ENSCHIP00000016938	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Uncharacterized protein.	0.487
ADAMTS1	THBS1	ENSCHIP00000002973	ENSCHIP00000018114	ADAM metallopeptidase with thrombospondin type 1 motif 1.	Thrombospondin 1.	0.422
AIF1	TLR4	ENSCHIP00000028430	ENSCHIP00000019512	Allograft inflammatory factor 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.407
AIF1	TNF	ENSCHIP00000028430	ENSCHIP00000004561	Allograft inflammatory factor 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.496
AKT1	DNMT1	ENSCHIP00000027335	ENSCHIP00000027359	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.452
AKT1	EDN1	ENSCHIP00000027335	ENSCHIP00000008821	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Endothelin 1.	0.422
AKT1	FGF2	ENSCHIP00000027335	ENSCHIP00000019134	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.476
AKT1	HMOX1	ENSCHIP00000027335	ENSCHIP00000016460	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heme oxygenase 1.	0.445
AKT1	IGF1	ENSCHIP00000027335	ENSCHIP00000020185	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.695
AKT1	JUN	ENSCHIP00000027335	ENSCHIP00000001903	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.963
AKT1	MMP2	ENSCHIP00000027335	ENSCHIP00000015816	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Matrix metallopeptidase 2.	0.544
AKT1	MMP9	ENSCHIP00000027335	ENSCHIP00000016938	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.617
AKT1	NF1	ENSCHIP00000027335	ENSCHIP00000007274	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Neurofibromin 1.	0.421
AKT1	NR4A3	ENSCHIP00000027335	ENSCHIP00000022269	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear receptor subfamily 4 group A member 3.	0.414
AKT1	TLR4	ENSCHIP00000027335	ENSCHIP00000019512	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.535
AKT1	TNF	ENSCHIP00000027335	ENSCHIP00000004561	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.622
BMP4	BMPR1A	ENSCHIP00000023678	ENSCHIP00000000640	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP4	EDN1	ENSCHIP00000023678	ENSCHIP00000008821	Bone morphogenetic protein 4.	Endothelin 1.	0.487