(41 nodes) Embryonic cranial skeleton morphogenesis network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRX5	Iroquois homeobox 5. (483 aa)
	SLC39A1	Uncharacterized protein. (324 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	MMP14	ZnMc domain-containing protein. (584 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	RUNX2	RUNX family transcription factor 2. (585 aa)
	CHST11	Carbohydrate sulfotransferase. (362 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	TBX15	T-box transcription factor 15. (602 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SLC39A3	Uncharacterized protein. (283 aa)
	WDR19	WD repeat domain 19. (1335 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	SIX1	SIX homeobox 1. (284 aa)
	ALX3	ALX homeobox 3. (343 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (975 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (488 aa)
	MED12	Med12 domain-containing protein. (2040 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2556 aa)
	TFAP2A	Transcription factor AP-2 alpha. (485 aa)
	PAX5	Paired box 5. (392 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	GRHL2	Grainyhead like transcription factor 2. (622 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (882 aa)
	IFT140	Intraflagellar transport 140. (1457 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	HOXA2	Homeobox A2. (372 aa)
	EIF4A3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	LHX1	LIM homeobox 1. (406 aa)
	NODAL	Nodal growth differentiation factor. (346 aa)
	ENSCHIP00000000097	Med12-PQL domain-containing protein. (315 aa)
	SIX2	SIX homeobox 2. (296 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
	PRRX1	Paired related homeobox 1. (245 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SIX4	SIX homeobox 4. (784 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	DLX2	ENSCHIP00000023678	ENSCHIP00000029902	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.542
BMP4	FGF8	ENSCHIP00000023678	ENSCHIP00000016903	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.763
BMP4	FGFR2	ENSCHIP00000023678	ENSCHIP00000018620	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.647
BMP4	GLI3	ENSCHIP00000023678	ENSCHIP00000014153	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.499
BMP4	LHX1	ENSCHIP00000023678	ENSCHIP00000025202	Bone morphogenetic protein 4.	LIM homeobox 1.	0.400
BMP4	PDGFRA	ENSCHIP00000023678	ENSCHIP00000002297	Bone morphogenetic protein 4.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.678
BMP4	RUNX2	ENSCHIP00000023678	ENSCHIP00000015454	Bone morphogenetic protein 4.	RUNX family transcription factor 2.	0.900
BMP4	SIX1	ENSCHIP00000023678	ENSCHIP00000029952	Bone morphogenetic protein 4.	SIX homeobox 1.	0.531
BMP4	SMAD2	ENSCHIP00000023678	ENSCHIP00000022106	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.866
BMP4	SMAD3	ENSCHIP00000023678	ENSCHIP00000011729	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.808
BMP4	TFAP2A	ENSCHIP00000023678	ENSCHIP00000019210	Bone morphogenetic protein 4.	Transcription factor AP-2 alpha.	0.445
BMP4	TGFBR1	ENSCHIP00000023678	ENSCHIP00000025782	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.799
BMP4	TGFBR2	ENSCHIP00000023678	ENSCHIP00000008226	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.657
DLX2	BMP4	ENSCHIP00000029902	ENSCHIP00000023678	Distal-less homeobox 2.	Bone morphogenetic protein 4.	0.542
DLX2	FGF8	ENSCHIP00000029902	ENSCHIP00000016903	Distal-less homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
DLX2	IRX5	ENSCHIP00000029902	ENSCHIP00000009248	Distal-less homeobox 2.	Iroquois homeobox 5.	0.455
DLX2	PDGFRA	ENSCHIP00000029902	ENSCHIP00000002297	Distal-less homeobox 2.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.521
DLX2	RUNX2	ENSCHIP00000029902	ENSCHIP00000015454	Distal-less homeobox 2.	RUNX family transcription factor 2.	0.435
DLX2	SIX1	ENSCHIP00000029902	ENSCHIP00000029952	Distal-less homeobox 2.	SIX homeobox 1.	0.417
FGF8	BMP4	ENSCHIP00000016903	ENSCHIP00000023678	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.763