(21 nodes) Smooth muscle tissue development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STRA6	Stimulated by retinoic acid 6. (654 aa)
	PROX1	Prospero homeobox 1. (734 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (901 aa)
	SIX1	SIX homeobox 1. (284 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (213 aa)
	ENG	Endoglin. (649 aa)
	LOC102180704	SCHIP-1 domain-containing protein. (260 aa)
	TFAP2B	Transcription factor AP-2 beta. (476 aa)
	ENSCHIP00000005724	Uncharacterized protein. (62 aa)
	NF1	Neurofibromin 1. (2848 aa)
	SRF	Serum response factor. (509 aa)
	PTCH1	Patched 1. (1453 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (656 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (978 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENG	ENSCHIP00000023678	ENSCHIP00000033223	Bone morphogenetic protein 4.	Endoglin.	0.417
BMP4	IHH	ENSCHIP00000023678	ENSCHIP00000016239	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.790
BMP4	PTCH1	ENSCHIP00000023678	ENSCHIP00000011891	Bone morphogenetic protein 4.	Patched 1.	0.737
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SIX1	ENSCHIP00000023678	ENSCHIP00000029952	Bone morphogenetic protein 4.	SIX homeobox 1.	0.531
BMP4	SMO	ENSCHIP00000023678	ENSCHIP00000027079	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.639
BMP4	SOX9	ENSCHIP00000023678	ENSCHIP00000024523	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.769
DLG1	DLG2	ENSCHIP00000006322	ENSCHIP00000029637	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 2.	0.901
DLG2	DLG1	ENSCHIP00000029637	ENSCHIP00000006322	Discs large MAGUK scaffold protein 2.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.901
ENG	BMP4	ENSCHIP00000033223	ENSCHIP00000023678	Endoglin.	Bone morphogenetic protein 4.	0.417
IHH	BMP4	ENSCHIP00000016239	ENSCHIP00000023678	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.790
IHH	PTCH1	ENSCHIP00000016239	ENSCHIP00000011891	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Patched 1.	0.999
IHH	SHH	ENSCHIP00000016239	ENSCHIP00000027767	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.950
IHH	SMO	ENSCHIP00000016239	ENSCHIP00000027079	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.975
IHH	SOX9	ENSCHIP00000016239	ENSCHIP00000024523	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	SRY-box transcription factor 9.	0.844
LOC102180704	TIPARP	ENSCHIP00000001921	ENSCHIP00000019850	SCHIP-1 domain-containing protein.	TCDD inducible poly(ADP-ribose) polymerase.	0.638
LOC102180704	ZFAND5	ENSCHIP00000001921	ENSCHIP00000031668	SCHIP-1 domain-containing protein.	Zinc finger AN1-type containing 5.	0.832
PKD2	SHH	ENSCHIP00000022411	ENSCHIP00000027767	Polycystin 2, transient receptor potential cation channel.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.411
PKD2	SMO	ENSCHIP00000022411	ENSCHIP00000027079	Polycystin 2, transient receptor potential cation channel.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.682
PTCH1	BMP4	ENSCHIP00000011891	ENSCHIP00000023678	Patched 1.	Bone morphogenetic protein 4.	0.737