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ACVR1 ACVR1 ISL1 ISL1 TGFBR1 TGFBR1 CORO1C CORO1C GSC GSC LOC108634739 LOC108634739 SEMA3F SEMA3F SEMA4B SEMA4B WNT11 WNT11 FN1 FN1 SOX9 SOX9 FRZB FRZB RET RET DDX17 DDX17 SEMA5B SEMA5B FOLR1 FOLR1 NOTCH1 NOTCH1 BMP4 BMP4 CYP26C1 CYP26C1 JAG1 JAG1 NOTCH4 NOTCH4 OSR1 OSR1 SOX10 SOX10 SEMA3E SEMA3E EDNRA EDNRA SMAD4 SMAD4 TASOR TASOR CDH2 CDH2 SEMA3D SEMA3D PEF1 PEF1 SEMA6A SEMA6A HES1 HES1 SEMA4G SEMA4G PHOX2B PHOX2B SEMA4C SEMA4C WWTR1 WWTR1 PHACTR4 PHACTR4 SEMA3C SEMA3C GBX2 GBX2 FGF8 FGF8 SOX8 SOX8 SEMA4F SEMA4F NOLC1 NOLC1 RDH10 RDH10 ANXA6 ANXA6 WNT16 WNT16 BCL2 BCL2 PPP3R1 PPP3R1 AMER1 AMER1 SEMA4D SEMA4D BMPR1A BMPR1A DLG5 DLG5 MAPK1 MAPK1 MEF2C MEF2C ROCK1 ROCK1 WNT5A WNT5A MAPK3 MAPK3 NRP2 NRP2 HIF1A HIF1A TCF21 TCF21 TGFBR3 TGFBR3 SEMA3A SEMA3A LOXL2 LOXL2 CUL7 CUL7 LRP6 LRP6 KBTBD8 KBTBD8 GSK3B GSK3B LOC102176871 LOC102176871 SNAI1 SNAI1 SFRP1 SFRP1 EPB41L5 EPB41L5 MSX1 MSX1 KLHL12 KLHL12 CDC42 CDC42 HMGA2 HMGA2 ZFP64 ZFP64 HEYL HEYL SEMA5A SEMA5A SEMA3B SEMA3B EFNA1 EFNA1 ADAM15 ADAM15 LOC102170800 LOC102170800 RTN4 RTN4 TCOF1 TCOF1 PDCD6 PDCD6 NRP1 NRP1 EFNB1 EFNB1 FAM172A FAM172A ENSCHIP00000005210 ENSCHIP00000005210 EXT1 EXT1 NOG NOG BMP7 BMP7 BMP2 BMP2 SIX2 SIX2 LAMA5 LAMA5 WNT2 WNT2 FGFR1 FGFR1 TBX20 TBX20 FLNA FLNA HAS2 HAS2 EDNRB EDNRB ENSCHIP00000008714 ENSCHIP00000008714 DDX5 DDX5 EDN1 EDN1 TGFB1 TGFB1 TBX3 TBX3 HAND2 HAND2 TRIM28 TRIM28 SEMA6D SEMA6D ENSCHIP00000009938 ENSCHIP00000009938 FGF10 FGF10 TMEM100 TMEM100 SEMA6C SEMA6C HEY2 HEY2 ENG ENG RFLNB RFLNB HTR2B HTR2B AKNA AKNA ALDH1A2 ALDH1A2 ERBB4 ERBB4 ALX1 ALX1 LEF1 LEF1 KITLG KITLG SEMA6B SEMA6B SEMA7A SEMA7A SIX1 SIX1 RADIL RADIL ENSCHIP00000029391 ENSCHIP00000029391 SNAI2 SNAI2 OTUD5 OTUD5 RANBP3L RANBP3L SHH SHH FAM83D FAM83D GDNF GDNF SMO SMO LOXL3 LOXL3 SEMA3G SEMA3G WNT10A WNT10A SEMA4A SEMA4A TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
GSCGoosecoid homeobox. (257 aa)
LOC108634739TGF_BETA_2 domain-containing protein. (197 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (764 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (826 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FN1Fibronectin 1. (2478 aa)
SOX9SRY-box transcription factor 9. (525 aa)
FRZBFrizzled related protein. (325 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (729 aa)
SEMA5BSemaphorin 5B. (1043 aa)
FOLR1Folate_rec domain-containing protein. (251 aa)
NOTCH1Notch receptor 1. (2508 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (523 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NOTCH4Notch receptor 4. (1966 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
SOX10SRY-box transcription factor 10. (469 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
TASORTranscription activation suppressor. (1631 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (775 aa)
PEF1Penta-EF-hand domain containing 1. (287 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
WWTR1WW domain containing transcription regulator 1. (419 aa)
PHACTR4Phosphatase and actin regulator. (714 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SOX8SRY-box transcription factor 8. (534 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (764 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (678 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ANXA6Annexin. (689 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
PPP3R1Uncharacterized protein. (170 aa)
AMER1Uncharacterized protein. (1101 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
HIF1AUncharacterized protein. (823 aa)
TCF21Transcription factor 21. (179 aa)
TGFBR3Transforming growth factor beta receptor 3. (859 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
LOXL2Lysyl oxidase like 2. (791 aa)
CUL7Cullin 7; Belongs to the cullin family. (1698 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
LOC102176871Uncharacterized protein. (921 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
EPB41L5FERM domain-containing protein. (505 aa)
MSX1Msh homeobox 1. (303 aa)
KLHL12Kelch like family member 12. (568 aa)
CDC42Uncharacterized protein. (191 aa)
HMGA2Uncharacterized protein. (104 aa)
ZFP64ZFP64 zinc finger protein. (680 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SEMA5ASemaphorin 5A. (1073 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
ADAM15ADAM metallopeptidase domain 15. (866 aa)
LOC102170800Uncharacterized protein. (537 aa)
RTN4Reticulon. (1194 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1451 aa)
PDCD6Uncharacterized protein. (185 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (373 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
ENSCHIP00000005210Uncharacterized protein. (237 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
SIX2SIX homeobox 2. (296 aa)
LAMA5Laminin subunit alpha 5. (2263 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGFR1Fibroblast growth factor receptor. (860 aa)
TBX20T-box transcription factor 20. (449 aa)
FLNAFilamin A. (2647 aa)
HAS2Uncharacterized protein. (552 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
ENSCHIP00000008714Uncharacterized protein. (170 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (622 aa)
EDN1Endothelin 1. (202 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TBX3T-box transcription factor 3. (749 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
TRIM28Tripartite motif containing 28. (837 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
ENSCHIP00000009938Annexin. (100 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
TMEM100Transmembrane protein 100. (134 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (964 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENGEndoglin. (649 aa)
RFLNBRefilin B. (216 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
AKNAAT-hook transcription factor. (1431 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ERBB4Protein kinase domain-containing protein. (462 aa)
ALX1ALX homeobox 1. (326 aa)
LEF1HMG box domain-containing protein. (430 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (920 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
SIX1SIX homeobox 1. (284 aa)
RADILRap associating with DIL domain. (1068 aa)
ENSCHIP00000029391Uncharacterized protein. (179 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
OTUD5OTU deubiquitinase 5. (566 aa)
RANBP3LRAN binding protein 3 like. (466 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
FAM83DFamily with sequence similarity 83 member D. (582 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
LOXL3Lysyl oxidase like 3. (752 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (769 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (762 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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