STRINGSTRING
MITF MITF LGR4 LGR4 ACVRL1 ACVRL1 PTN PTN NCDN NCDN EFNA2 EFNA2 PTK2B PTK2B P3H4 P3H4 CTNNB1 CTNNB1 THBS4 THBS4 RASSF2 RASSF2 LRRK1 LRRK1 VDR VDR LTBP3 LTBP3 CRB1 CRB1 NOTCH2 NOTCH2 CAPN1 CAPN1 F2R F2R TPH1 TPH1 TGFB3 TGFB3 BSX BSX GJA1 GJA1 SRC SRC PTH1R PTH1R NFKB1 NFKB1 HTR1B HTR1B EXT1 EXT1 TIMP1 TIMP1 CBS CBS ELF3 ELF3 IL23A IL23A CELA1 CELA1 PLG PLG IL1A IL1A FLNA FLNA CTSK CTSK CHD7 CHD7 TGFB1 TGFB1 FGF10 FGF10 CTHRC1 CTHRC1 IL7 IL7 TIE1 TIE1 RSPO3 RSPO3 CCDC154 CCDC154 LIF LIF HOXA3 HOXA3 ACP5 ACP5 IAPP IAPP RAB3D RAB3D TNFSF11 TNFSF11 DBH DBH UMOD UMOD DLL4 DLL4 EPHA2 EPHA2 HIF1A HIF1A TRAF6 TRAF6 BAK1 BAK1 MEF2C MEF2C MMP2 MMP2 GPR55 GPR55 WNT16 WNT16 IHH IHH EPAS1 EPAS1 FGF8 FGF8 SEMA3C SEMA3C NOL3 NOL3 HNF1A HNF1A CAV1 CAV1 LRP5 LRP5 ATG5 ATG5 EDNRA EDNRA LIPA LIPA BMPR2 BMPR2 AXL AXL CCR2 CCR2 JAG1 JAG1 SPP2 SPP2 SNX10 SNX10 NOX4 NOX4 TCIRG1 TCIRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MITFMelanocyte inducing transcription factor. (519 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PTNPleiotrophin. (183 aa)
NCDNNeurochondrin. (753 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (213 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (432 aa)
CTNNB1Catenin beta 1. (781 aa)
THBS4Thrombospondin 4. (965 aa)
RASSF2Ras association domain family member 2. (326 aa)
LRRK1Leucine rich repeat kinase 1. (2039 aa)
VDRVitamin D receptor. (491 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1294 aa)
CRB1Crumbs cell polarity complex component 1. (1409 aa)
NOTCH2Notch receptor 2. (2471 aa)
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (744 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
BSXBrain specific homeobox. (232 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
SRCTyrosine-protein kinase. (538 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (589 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
HTR1B5-hydroxytryptamine receptor 1B. (389 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
TIMP1NTR domain-containing protein. (207 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (586 aa)
ELF3E74 like ETS transcription factor 3. (372 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (266 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
FLNAFilamin A. (2647 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
IL7Interleukin 7. (181 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
RSPO3R-spondin 3. (303 aa)
CCDC154Coiled-coil domain containing 154. (672 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
HOXA3Homeobox A3. (437 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (343 aa)
IAPPIslet amyloid polypeptide. (94 aa)
RAB3DRAB3D, member RAS oncogene family. (219 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
DBHDopamine beta-hydroxylase. (616 aa)
UMODUromodulin. (643 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
EPHA2EPH receptor A2. (975 aa)
HIF1AUncharacterized protein. (823 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (329 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
EPAS1Endothelial PAS domain protein 1. (898 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
NOL3Nucleolar protein 3. (230 aa)
HNF1AHNF1 homeobox A. (631 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (339 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SPP2Secreted phosphoprotein 2. (224 aa)
SNX10Sorting nexin 10. (200 aa)
NOX4NADPH oxidase 4. (578 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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