(48 nodes) Artery morphogenesis network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1072 aa)
	FOXF1	Forkhead box F1. (391 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	TFAP2B	Transcription factor AP-2 beta. (476 aa)
	HOXA13	Homeobox A13. (388 aa)
	ADGRF5	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	PRRX1	Paired related homeobox 1. (245 aa)
	NF1	Neurofibromin 1. (2848 aa)
	ARID2	AT-rich interaction domain 2. (1835 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2993 aa)
	EDN1	Endothelin 1. (202 aa)
	SRF	Serum response factor. (509 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (569 aa)
	TBX2	T-box transcription factor 2. (771 aa)
	COMP	Cartilage oligomeric matrix protein. (757 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
	FOXH1	Forkhead box H1. (360 aa)
	APOB	Apolipoprotein B. (4620 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	ANGPTL3	Fibrinogen C-terminal domain-containing protein. (459 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1261 aa)
	LRP2	LDL receptor related protein 2. (4649 aa)
	SMAD7	Mothers against decapentaplegic homolog. (427 aa)
	LDLR	Low density lipoprotein receptor. (787 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (978 aa)
	STRA6	Stimulated by retinoic acid 6. (654 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	FOLR1	Folate_rec domain-containing protein. (251 aa)
	MYOCD	Myocardin. (982 aa)
	PROX1	Prospero homeobox 1. (734 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	FKBP10	Peptidylprolyl isomerase. (574 aa)
	APOE	Apolipoprotein E. (326 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	PRDM1	PR/SET domain 1. (851 aa)
	HPGD	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
	SIX1	SIX homeobox 1. (284 aa)
	ENG	Endoglin. (649 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMP4	ENSCHIP00000033488	ENSCHIP00000023678	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.920
ACVRL1	BMPR1A	ENSCHIP00000033488	ENSCHIP00000000640	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.415
ACVRL1	BMPR2	ENSCHIP00000033488	ENSCHIP00000022191	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.969
ACVRL1	ENG	ENSCHIP00000033488	ENSCHIP00000033223	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.846
ACVRL1	SMAD7	ENSCHIP00000033488	ENSCHIP00000021001	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.746
ANGPTL3	APOB	ENSCHIP00000019169	ENSCHIP00000016374	Fibrinogen C-terminal domain-containing protein.	Apolipoprotein B.	0.580
ANGPTL3	SEC24B	ENSCHIP00000019169	ENSCHIP00000019232	Fibrinogen C-terminal domain-containing protein.	SEC24 homolog B, COPII coat complex component.	0.538
ANGPTL3	STRA6	ENSCHIP00000019169	ENSCHIP00000022707	Fibrinogen C-terminal domain-containing protein.	Stimulated by retinoic acid 6.	0.437
APOB	ANGPTL3	ENSCHIP00000016374	ENSCHIP00000019169	Apolipoprotein B.	Fibrinogen C-terminal domain-containing protein.	0.580
APOB	APOE	ENSCHIP00000016374	ENSCHIP00000025098	Apolipoprotein B.	Apolipoprotein E.	0.995
APOB	LDLR	ENSCHIP00000016374	ENSCHIP00000021255	Apolipoprotein B.	Low density lipoprotein receptor.	0.749
APOB	LRP2	ENSCHIP00000016374	ENSCHIP00000020275	Apolipoprotein B.	LDL receptor related protein 2.	0.615
APOE	APOB	ENSCHIP00000025098	ENSCHIP00000016374	Apolipoprotein E.	Apolipoprotein B.	0.995
APOE	EDN1	ENSCHIP00000025098	ENSCHIP00000008821	Apolipoprotein E.	Endothelin 1.	0.509
APOE	LDLR	ENSCHIP00000025098	ENSCHIP00000021255	Apolipoprotein E.	Low density lipoprotein receptor.	0.425
APOE	LRP2	ENSCHIP00000025098	ENSCHIP00000020275	Apolipoprotein E.	LDL receptor related protein 2.	0.977
ARID2	NF1	ENSCHIP00000007348	ENSCHIP00000007274	AT-rich interaction domain 2.	Neurofibromin 1.	0.506
BMP4	ACVRL1	ENSCHIP00000023678	ENSCHIP00000033488	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.920
BMP4	BMPR1A	ENSCHIP00000023678	ENSCHIP00000000640	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP4	BMPR2	ENSCHIP00000023678	ENSCHIP00000022191	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997