STRINGSTRING
EPCAM EPCAM EXT1 EXT1 BATF BATF EPOP EPOP SETD6 SETD6 FAM172A FAM172A PSMD11 PSMD11 EFNB1 EFNB1 NRP1 NRP1 PDCD6 PDCD6 TCOF1 TCOF1 EZH2 EZH2 SOX10 SOX10 OSR1 OSR1 SOX17 SOX17 JAG1 JAG1 CYP26C1 CYP26C1 NOTCH1 NOTCH1 FOLR1 FOLR1 SEMA5B SEMA5B MYOCD MYOCD PHF19 PHF19 RET RET FRZB FRZB SOX9 SOX9 FN1 FN1 ZIC3 ZIC3 SEMA4B SEMA4B HOXA7 HOXA7 SEMA3F SEMA3F LOC108634739 LOC108634739 XRCC5 XRCC5 GSC GSC WNT7A WNT7A CORO1C CORO1C KIT KIT PTPRC PTPRC ISL1 ISL1 ACVR1 ACVR1 TGFB2 TGFB2 SEMA4A SEMA4A WNT10A WNT10A SEMA3G SEMA3G SFRP2 SFRP2 ERCC2 ERCC2 SMO SMO GDNF GDNF ZFP36 ZFP36 GPM6B GPM6B FOXA1 FOXA1 SHH SHH TP63 TP63 HESX1 HESX1 TAL1 TAL1 SLC9A1 SLC9A1 OTUD5 OTUD5 MTF2 MTF2 MED1 MED1 SNAI2 SNAI2 ENSCHIP00000029391 ENSCHIP00000029391 RADIL RADIL CDX2 CDX2 SIX1 SIX1 TP53 TP53 SEMA7A SEMA7A SEMA6B SEMA6B KITLG KITLG HOXB4 HOXB4 ALX1 ALX1 SOX18 SOX18 CTNNB1 CTNNB1 ERBB4 ERBB4 JARID2 JARID2 BBS12 BBS12 ENSCHIP00000001557 ENSCHIP00000001557 SEMA4D SEMA4D BMPR1A BMPR1A MAPK1 MAPK1 ALDH1A2 ALDH1A2 DNMT3L DNMT3L HTR2B HTR2B ENSCHIP00000033232 ENSCHIP00000033232 SP7 SP7 NELFB NELFB SEMA6C SEMA6C NOG NOG ZNF281 ZNF281 GREM1 GREM1 ITGB1 ITGB1 LAMA5 LAMA5 TBXT TBXT EDNRB EDNRB CDK6 CDK6 ENSCHIP00000008714 ENSCHIP00000008714 EDN1 EDN1 SRF SRF NANOG NANOG TBX3 TBX3 FZD1 FZD1 HAND2 HAND2 SEMA6D SEMA6D ENSCHIP00000009938 ENSCHIP00000009938 ECE2 ECE2 PUM1 PUM1 SEMA3B SEMA3B FOXO4 FOXO4 SEMA5A SEMA5A METTL5 METTL5 SHC4 SHC4 HMGA2 HMGA2 CDC42 CDC42 KLHL12 KLHL12 ESR1 ESR1 MSX1 MSX1 LIF LIF DMRTA2 DMRTA2 SFRP1 SFRP1 TBX2 TBX2 KBTBD8 KBTBD8 GPM6A GPM6A LRP6 LRP6 ELL3 ELL3 SEMA3A SEMA3A LMBR1L LMBR1L HIF1A HIF1A REST REST PHF5A PHF5A HNF1B HNF1B RUNX2 RUNX2 NRP2 NRP2 MAPK3 MAPK3 MEF2C MEF2C BCL2 BCL2 ANXA6 ANXA6 MSI2 MSI2 RDH10 RDH10 UFL1 UFL1 NOLC1 NOLC1 SEMA4F SEMA4F SOX8 SOX8 GBX2 GBX2 SEMA3C SEMA3C PHACTR4 PHACTR4 SEMA4C SEMA4C PHOX2B PHOX2B SEMA4G SEMA4G HES1 HES1 SEMA6A SEMA6A FGF2 FGF2 PEF1 PEF1 SEMA3D SEMA3D SETD2 SETD2 CDH2 CDH2 WNT3 WNT3 GATA6 GATA6 SH2B3 SH2B3 SMAD4 SMAD4 MLLT3 MLLT3 SOX21 SOX21 HOXD4 HOXD4 EDNRA EDNRA SEMA3E SEMA3E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPCAMEpithelial cell adhesion molecule. (314 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (449 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (373 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PDCD6Uncharacterized protein. (185 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1451 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
SOX10SRY-box transcription factor 10. (469 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
SOX17SRY-box transcription factor 17. (410 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (523 aa)
NOTCH1Notch receptor 1. (2508 aa)
FOLR1Folate_rec domain-containing protein. (251 aa)
SEMA5BSemaphorin 5B. (1043 aa)
MYOCDMyocardin. (982 aa)
PHF19PHD finger protein 19. (580 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
FRZBFrizzled related protein. (325 aa)
SOX9SRY-box transcription factor 9. (525 aa)
FN1Fibronectin 1. (2478 aa)
ZIC3Zic family member 3. (465 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (826 aa)
HOXA7Homeobox A7. (239 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (764 aa)
LOC108634739TGF_BETA_2 domain-containing protein. (197 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
GSCGoosecoid homeobox. (257 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (762 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (769 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
GPM6BGlycoprotein M6B. (326 aa)
FOXA1Forkhead box A1. (468 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
HESX1HESX homeobox 1. (185 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (818 aa)
OTUD5OTU deubiquitinase 5. (566 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ENSCHIP00000029391Uncharacterized protein. (179 aa)
RADILRap associating with DIL domain. (1068 aa)
CDX2Caudal type homeobox 2. (306 aa)
SIX1SIX homeobox 1. (284 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (920 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
HOXB4Homeobox B4. (251 aa)
ALX1ALX homeobox 1. (326 aa)
SOX18SRY-box transcription factor 18. (393 aa)
CTNNB1Catenin beta 1. (781 aa)
ERBB4Protein kinase domain-containing protein. (462 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1258 aa)
BBS12Bardet-Biedl syndrome 12. (709 aa)
ENSCHIP00000001557Ig-like domain-containing protein. (122 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
DNMT3LPHD-type domain-containing protein. (390 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
ENSCHIP00000033232Uncharacterized protein. (321 aa)
SP7Sp7 transcription factor. (431 aa)
NELFBNegative elongation factor complex member B. (817 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (964 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ZNF281Zinc finger protein 281. (873 aa)
GREM1Gremlin. (184 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LAMA5Laminin subunit alpha 5. (2263 aa)
TBXTT-box transcription factor T. (435 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ENSCHIP00000008714Uncharacterized protein. (170 aa)
EDN1Endothelin 1. (202 aa)
SRFSerum response factor. (509 aa)
NANOGHomeobox domain-containing protein. (300 aa)
TBX3T-box transcription factor 3. (749 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
ENSCHIP00000009938Annexin. (100 aa)
ECE2EEF1AKMT4-ECE2 readthrough. (883 aa)
PUM1Pumilio RNA binding family member 1. (1186 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
FOXO4Forkhead box O4. (535 aa)
SEMA5ASemaphorin 5A. (1073 aa)
METTL5Methyltransferase like 5. (209 aa)
SHC4SHC adaptor protein 4. (630 aa)
HMGA2Uncharacterized protein. (104 aa)
CDC42Uncharacterized protein. (191 aa)
KLHL12Kelch like family member 12. (568 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
MSX1Msh homeobox 1. (303 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
DMRTA2DMRT like family A2. (535 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
TBX2T-box transcription factor 2. (771 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
GPM6AGlycoprotein M6A. (278 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (492 aa)
HIF1AUncharacterized protein. (823 aa)
RESTUncharacterized protein. (998 aa)
PHF5APHD finger protein 5A. (107 aa)
HNF1BHNF1 homeobox B. (558 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
ANXA6Annexin. (689 aa)
MSI2Musashi RNA binding protein 2. (328 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
UFL1UFM1 specific ligase 1. (792 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (678 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (764 aa)
SOX8SRY-box transcription factor 8. (534 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
PHACTR4Phosphatase and actin regulator. (714 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PEF1Penta-EF-hand domain containing 1. (287 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (775 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2556 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GATA6GATA binding protein 6. (592 aa)
SH2B3SH2B adaptor protein 3. (550 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
MLLT3MLLT3 super elongation complex subunit. (565 aa)
SOX21SRY-box transcription factor 21. (277 aa)
HOXD4Homeobox D4. (258 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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