STRINGSTRING
IRS2 IRS2 CD38 CD38 TNFSF13B TNFSF13B TNFSF9 TNFSF9 CDKN1A CDKN1A IL6ST IL6ST EFNB1 EFNB1 FADD FADD HHLA2 HHLA2 SLAMF1 SLAMF1 CD80 CD80 CD81 CD81 NCKAP1L NCKAP1L NCK2 NCK2 IL23A IL23A DHPS DHPS SPTA1 SPTA1 TGFBR2 TGFBR2 SYK SYK RPS3 RPS3 CD3E CD3E NCK1 NCK1 FGF10 FGF10 GPR183 GPR183 IL7 IL7 NFATC2 NFATC2 AGER AGER CD74 CD74 FOXP3 FOXP3 PTPN22 PTPN22 IL27RA IL27RA TRAF6 TRAF6 ENSCHIP00000015226 ENSCHIP00000015226 CD86 CD86 PRKCQ PRKCQ VAV3 VAV3 WNT3A WNT3A MEF2C MEF2C BCL2 BCL2 BMI1 BMI1 ATAD5 ATAD5 TNFRSF13C TNFRSF13C IL12B IL12B SLC7A1 SLC7A1 CLCF1 CLCF1 HAVCR2 HAVCR2 CD274 CD274 MYD88 MYD88 HES1 HES1 RASAL3 RASAL3 CCL19 CCL19 TLR4 TLR4 RIPK2 RIPK2 TYK2 TYK2 IGF1 IGF1 CCDC88B CCDC88B IL4 IL4 LEP LEP VTCN1 VTCN1 TNFSF4 TNFSF4 CD6 CD6 BTNL2 BTNL2 BST1 BST1 SASH3 SASH3 GPAM GPAM ANXA1 ANXA1 IGF2 IGF2 CARD11 CARD11 IL18 IL18 CD320 CD320 ENSCHIP00000024183 ENSCHIP00000024183 CORO1A CORO1A STAT5B STAT5B ZP3 ZP3 PELI1 PELI1 ZNF335 ZNF335 STAT5A STAT5A PTPRC PTPRC EPHB2 EPHB2 IL12A IL12A PYCARD PYCARD IL21 IL21 SHH SHH SELENOK SELENOK AIF1 AIF1 CD40 CD40 TLR9 TLR9 PDCD1LG2 PDCD1LG2 IL1B IL1B IL15 IL15 CD28 CD28 IL2 IL2 KITLG KITLG IGFBP2 IGFBP2 ZP4 ZP4 BCL6 BCL6 LOC102187998 LOC102187998 PPP3CA PPP3CA IL12RB2 IL12RB2 TFRC TFRC ADA ADA IL12RB1 IL12RB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRS2Insulin receptor substrate 2. (1465 aa)
CD38Uncharacterized protein. (277 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
TNFSF9TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (373 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
HHLA2HERV-H LTR-associating 2. (419 aa)
SLAMF1Ig-like domain-containing protein. (338 aa)
CD80CD80 molecule. (302 aa)
CD81Tetraspanin. (236 aa)
NCKAP1LNCK associated protein 1 like. (1178 aa)
NCK2Cytoplasmic protein. (376 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
DHPSUncharacterized protein. (369 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2402 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CD3ECD3e molecule. (194 aa)
NCK1Cytoplasmic protein. (377 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (356 aa)
IL7Interleukin 7. (181 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
CD74CD74 molecule. (261 aa)
FOXP3Forkhead box P3. (463 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (795 aa)
IL27RAInterleukin 27 receptor subunit alpha. (655 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
ENSCHIP00000015226KH type-2 domain-containing protein. (204 aa)
CD86Ig-like domain-containing protein. (289 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (711 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
BMI1RING-type domain-containing protein. (437 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
TNFRSF13CTNF receptor superfamily member 13C. (177 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
CLCF1Cardiotrophin like cytokine factor 1. (220 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
CD274CD274 molecule. (289 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RASAL3RAS protein activator like 3. (1013 aa)
CCL19C-C motif chemokine. (102 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
CCDC88BCoiled-coil domain containing 88B. (1455 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (270 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
CD6CD6 molecule. (672 aa)
BTNL2Butyrophilin like 2. (522 aa)
BST1Bone marrow stromal cell antigen 1. (333 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (844 aa)
ANXA1Annexin. (346 aa)
IGF2Insulin-like growth factor II. (179 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CD320CD320. (255 aa)
ENSCHIP00000024183Uncharacterized protein. (207 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
ZP3ZP domain-containing protein. (432 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ZNF335Zinc finger protein 335. (1345 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
EPHB2EPH receptor B2. (1016 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
PYCARDPYD and CARD domain containing. (196 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (157 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
SELENOKSelenoprotein K. (85 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CD40CD40 molecule. (280 aa)
TLR9TIR domain-containing protein. (1070 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (296 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
CD28CD28 molecule. (228 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
IGFBP2Uncharacterized protein. (326 aa)
ZP4Zona pellucida glycoprotein 4. (531 aa)
BCL6BCL6 transcription repressor. (706 aa)
LOC102187998Ig-like domain-containing protein. (262 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (877 aa)
TFRCTransferrin receptor. (790 aa)
ADAAdenosine deaminase. (400 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (730 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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