STRINGSTRING
REST REST YWHAH YWHAH WNT5A WNT5A WNT3A WNT3A HOOK3 HOOK3 SEMA4F SEMA4F SEMA3C SEMA3C SEMA4C SEMA4C NR1D1 NR1D1 SEMA4G SEMA4G HES1 HES1 SEMA6A SEMA6A SEMA3D SEMA3D PCM1 PCM1 WNT3 WNT3 ULK1 ULK1 KIFAP3 KIFAP3 MT3 MT3 KIAA0319 KIAA0319 LDLR LDLR SEMA3E SEMA3E EPHA7 EPHA7 NR2E1 NR2E1 SORL1 SORL1 NTN1 NTN1 NOTCH1 NOTCH1 SEMA5B SEMA5B PROX1 PROX1 SEMA4B SEMA4B HES5 HES5 SEMA3F SEMA3F PLXNA3 PLXNA3 DRAXIN DRAXIN DLX6 DLX6 WNT7A WNT7A CTDSP1 CTDSP1 SEMA4A SEMA4A EPHB2 EPHB2 SEMA3G SEMA3G FSTL4 FSTL4 RYK RYK PAX6 PAX6 NKX6-1 NKX6-1 NFATC4 NFATC4 F2 F2 THY1 THY1 SPART SPART TLX2 TLX2 LHX2 LHX2 LRP4 LRP4 DLX2 DLX2 SOX11 SOX11 TP53 TP53 SEMA7A SEMA7A SEMA6B SEMA6B PSEN1 PSEN1 CTNNB1 CTNNB1 RAPGEF2 RAPGEF2 RTN4R RTN4R CDK5 CDK5 DPYSL5 DPYSL5 PPP3CA PPP3CA ENSCHIP00000033232 ENSCHIP00000033232 ENSCHIP00000033272 ENSCHIP00000033272 PTN PTN IFRD2 IFRD2 TMEM98 TMEM98 PTPRS PTPRS SEMA6C SEMA6C EFNB3 EFNB3 SEMA3A SEMA3A DNAJB11 DNAJB11 PRTG PRTG DAAM2 DAAM2 SYNGAP1 SYNGAP1 DLX1 DLX1 NF2 NF2 GORASP1 GORASP1 SEMA5A SEMA5A SEMA3B SEMA3B CCL11 CCL11 SEMA6D SEMA6D SKI SKI GDI1 GDI1 ATOH1 ATOH1 NF1 NF1 BRINP1 BRINP1 TRIM11 TRIM11 APPL2 APPL2 GPR37L1 GPR37L1 BMP7 BMP7 DIP2B DIP2B NOG NOG DLL3 DLL3 TNR TNR CDKL3 CDKL3 TREM2 TREM2 RTN4 RTN4 CTNNA1 CTNNA1 RB1 RB1 VAX1 VAX1 NKX6-2 NKX6-2 SEMA4D SEMA4D BMPR1A BMPR1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RESTUncharacterized protein. (998 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
HOOK3Hook microtubule tethering protein 3. (719 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (764 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (616 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (775 aa)
PCM1Pericentriolar material 1. (2194 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1055 aa)
KIFAP3Kinesin associated protein 3. (749 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
KIAA0319KIAA0319. (1066 aa)
LDLRLow density lipoprotein receptor. (787 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
EPHA7EPH receptor A7. (998 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
SORL1Sortilin related receptor 1. (2211 aa)
NTN1Netrin 1. (496 aa)
NOTCH1Notch receptor 1. (2508 aa)
SEMA5BSemaphorin 5B. (1043 aa)
PROX1Prospero homeobox 1. (734 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (826 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (764 aa)
PLXNA3Plexin A3. (1822 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (346 aa)
DLX6Distal-less homeobox 6. (230 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (762 aa)
EPHB2EPH receptor B2. (1016 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (769 aa)
FSTL4Follistatin like 4. (843 aa)
RYKReceptor like tyrosine kinase. (609 aa)
PAX6Paired box 6. (486 aa)
NKX6-1NK6 homeobox 1. (367 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
THY1Thy-1 cell surface antigen. (161 aa)
SPARTSpartin. (668 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
LHX2Uncharacterized protein. (422 aa)
LRP4LDL receptor related protein 4. (1901 aa)
DLX2Distal-less homeobox 2. (328 aa)
SOX11Transcription factor SOX. (444 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (920 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
CTNNB1Catenin beta 1. (781 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1675 aa)
RTN4RReticulon 4 receptor. (473 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
DPYSL5Dihydropyrimidinase like 5. (557 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
ENSCHIP00000033232Uncharacterized protein. (321 aa)
ENSCHIP00000033272FERM domain-containing protein. (580 aa)
PTNPleiotrophin. (183 aa)
IFRD2Interferon related developmental regulator 2. (442 aa)
TMEM98Transmembrane protein 98. (226 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1926 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (964 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
DNAJB11J domain-containing protein. (358 aa)
PRTGProtogenin. (1160 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1087 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1322 aa)
DLX1Distal-less homeobox 1. (255 aa)
NF2FERM domain-containing protein. (612 aa)
GORASP1Golgi reassembly stacking protein 1. (441 aa)
SEMA5ASemaphorin 5A. (1073 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
CCL11C-C motif chemokine. (97 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
SKISKI proto-oncogene. (729 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (406 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
NF1Neurofibromin 1. (2848 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (761 aa)
TRIM11Tripartite motif containing 11. (468 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
GPR37L1G protein-coupled receptor 37 like 1. (478 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
DIP2BDisco interacting protein 2 homolog B. (1554 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DLL3Delta like canonical Notch ligand 3. (595 aa)
TNRTenascin R. (1358 aa)
CDKL3Cyclin dependent kinase like 3. (717 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
RTN4Reticulon. (1194 aa)
CTNNA1Catenin alpha 1. (1018 aa)
RB1RB transcriptional corepressor 1. (931 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
NKX6-2NK6 homeobox 2. (286 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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