STRINGSTRING
SFN SFN AQP7 AQP7 LOC102170800 LOC102170800 TFAP2B TFAP2B HYAL2 HYAL2 ACER1 ACER1 EXT1 EXT1 SCNN1A SCNN1A ENSCHIP00000006081 ENSCHIP00000006081 AQP4 AQP4 KRT16 KRT16 HAS2 HAS2 SRF SRF FA2H FA2H ENSCHIP00000009957 ENSCHIP00000009957 AKAP11 AKAP11 TRPV4 TRPV4 ATP6V1B1 ATP6V1B1 TMPRSS11F TMPRSS11F UMOD UMOD LSR LSR CYP26B1 CYP26B1 CFTR CFTR SCNN1G SCNN1G GRHL3 GRHL3 ABCA12 ABCA12 MLLT6 MLLT6 PNPLA1 PNPLA1 HRNR HRNR IL18 IL18 AQP3 AQP3 CLDN1 CLDN1 SCNN1B SCNN1B ENSCHIP00000025260 ENSCHIP00000025260 PLEC PLEC ALOX12B ALOX12B STARD7 STARD7 ALOXE3 ALOXE3 TP63 TP63 AQP2 AQP2 TMEM79 TMEM79 KDF1 KDF1 BPIFA1 BPIFA1 MET MET ALOX12 ALOX12 UGCG UGCG WFS1 WFS1 EXT2 EXT2 ENSCHIP00000032150 ENSCHIP00000032150 AQP1 AQP1 GRHL1 GRHL1 KRT1 KRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
AQP7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (330 aa)
LOC102170800Uncharacterized protein. (537 aa)
TFAP2BTranscription factor AP-2 beta. (476 aa)
HYAL2Hyaluronidase. (476 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (672 aa)
ENSCHIP00000006081Uncharacterized protein. (72 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (445 aa)
HAS2Uncharacterized protein. (552 aa)
SRFSerum response factor. (509 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
ENSCHIP00000009957Calponin-homology (CH) domain-containing protein. (123 aa)
AKAP11A-kinase anchoring protein 11. (1905 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (437 aa)
UMODUromodulin. (643 aa)
LSRLipolysis stimulated lipoprotein receptor. (621 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1524 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (652 aa)
GRHL3Grainyhead like transcription factor 3. (600 aa)
ABCA12ATP binding cassette subfamily A member 12. (2589 aa)
MLLT6MLLT6, PHD finger containing. (1094 aa)
PNPLA1Patatin like phospholipase domain containing 1. (535 aa)
HRNRUncharacterized protein. (3037 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (774 aa)
ENSCHIP00000025260Uncharacterized protein. (1966 aa)
PLECPlectin. (4150 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (699 aa)
STARD7StAR related lipid transfer domain containing 7. (383 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
AQP2Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
TMEM79Transmembrane protein 79. (395 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
BPIFA1BPI fold containing family A member 1. (229 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (659 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
WFS1Wolframin ER transmembrane glycoprotein. (876 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (737 aa)
ENSCHIP00000032150Uncharacterized protein. (603 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
GRHL1CP2 domain-containing protein. (617 aa)
KRT1Keratin 1; Belongs to the intermediate filament family. (614 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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