STRINGSTRING
DEFB124 DEFB124 P2RX4 P2RX4 MSTN MSTN RYK RYK LOC108633275 LOC108633275 CCL26 CCL26 CALR CALR CCL2 CCL2 VEGFD VEGFD CXCL17 CXCL17 AIF1 AIF1 DNM1L DNM1L EDN2 EDN2 VEGFC VEGFC LGMN LGMN THBS4 THBS4 NOD2 NOD2 VEGFB VEGFB SMOC2 SMOC2 RAC2 RAC2 MET MET SEMA7A SEMA7A NEDD9 NEDD9 DPP4 DPP4 TNFSF14 TNFSF14 CCR2 CCR2 ENSCHIP00000022713 ENSCHIP00000022713 BST1 BST1 GPSM3 GPSM3 EFNB2 EFNB2 IL34 IL34 BMPR2 BMPR2 CXCL8 CXCL8 ARTN ARTN SEMA3E SEMA3E ATOH7 ATOH7 SPI1 SPI1 LBP LBP HABP2 HABP2 STK39 STK39 ANGPT2 ANGPT2 CCR7 CCR7 MCU MCU WNT3 WNT3 CCL19 CCL19 SEMA3D SEMA3D FGF2 FGF2 SEMA6A SEMA6A SEMA4G SEMA4G THBS1 THBS1 PRKD1 PRKD1 PADI2 PADI2 CORO1B CORO1B SEMA4C SEMA4C ROBO1 ROBO1 SEMA3C SEMA3C LOC102181154 LOC102181154 ADGRA2 ADGRA2 LOC102190717 LOC102190717 STX3 STX3 CXCL13 CXCL13 SEMA4F SEMA4F S100A14 S100A14 CCL5 CCL5 MTUS1 MTUS1 C5AR1 C5AR1 WNT3A WNT3A AKIRIN1 AKIRIN1 WNT5A WNT5A MAPK3 MAPK3 HSPB1 HSPB1 RIN3 RIN3 GAS6 GAS6 SEMA3A SEMA3A DEF6 DEF6 CXCL10 CXCL10 MEGF8 MEGF8 CXCR3 CXCR3 MST1 MST1 LOC102179590 LOC102179590 TMEM102 TMEM102 MPP1 MPP1 CD74 CD74 PLA2G7 PLA2G7 AGER AGER CXCR4 CXCR4 TRPV4 TRPV4 PTPN2 PTPN2 ADAM17 ADAM17 ENSCHIP00000011519 ENSCHIP00000011519 MYCBP2 MYCBP2 SEMA5A SEMA5A TNFAIP6 TNFAIP6 SEMA3B SEMA3B ENSCHIP00000010266 ENSCHIP00000010266 GPR183 GPR183 FGF10 FGF10 SEMA6D SEMA6D NTF3 NTF3 POU4F2 POU4F2 WNK1 WNK1 FEZF2 FEZF2 TGFB1 TGFB1 TBR1 TBR1 KLRK1 KLRK1 FGF16 FGF16 FGF18 FGF18 CDH13 CDH13 MOSPD2 MOSPD2 ENSCHIP00000007700 ENSCHIP00000007700 C5 C5 FGFR1 FGFR1 CXCL12 CXCL12 IL23A IL23A DSCAM DSCAM NTRK3 NTRK3 SCG2 SCG2 LOC102179713 LOC102179713 FGF4 FGF4 CMKLR1 CMKLR1 JAM3 JAM3 CREB3 CREB3 RARRES2 RARRES2 NCKAP1L NCKAP1L SLAMF1 SLAMF1 VEGFA VEGFA CXCL14 CXCL14 IL16 IL16 SUCNR1 SUCNR1 TREM2 TREM2 CX3CR1 CX3CR1 C3AR1 C3AR1 RIPOR2 RIPOR2 ADAM10 ADAM10 CAMK1D CAMK1D KDR KDR PRSS56 PRSS56 USP14 USP14 FAM49B FAM49B PDGFRA PDGFRA C5AR2 C5AR2 ENSCHIP00000001557 ENSCHIP00000001557 LOC102179993 LOC102179993 TPBG TPBG ANO6 ANO6 SWAP70 SWAP70 ENSCHIP00000000870 ENSCHIP00000000870 SEMA4D SEMA4D NOTCH1 NOTCH1 SEMA5B SEMA5B PRKD2 PRKD2 SEMA4B SEMA4B DUSP1 DUSP1 SEMA3F SEMA3F PGF PGF PLXNA3 PLXNA3 LYN LYN CCL27 CCL27 SEMA4A SEMA4A GPR18 GPR18 IL12A IL12A MAPK1 MAPK1 PPM1F PPM1F F7 F7 C1QBP C1QBP SEMA6B SEMA6B SEMA6C SEMA6C CSF1 CSF1 MMP28 MMP28 PTN PTN STAP1 STAP1 FGF1 FGF1 CSF1R CSF1R OCM2 OCM2 F2RL1 F2RL1 SLIT2 SLIT2 PTK2B PTK2B ENSCHIP00000031698 ENSCHIP00000031698 LOC102190981 LOC102190981 CCL21 CCL21 PDGFB PDGFB HRG HRG CCR6 CCR6 SEMA3G SEMA3G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (460 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
RYKReceptor like tyrosine kinase. (609 aa)
LOC108633275TNF_2 domain-containing protein. (230 aa)
CCL26C-C motif chemokine. (94 aa)
CALRCalreticulin. (417 aa)
CCL2C-C motif chemokine. (98 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CXCL17Uncharacterized protein. (119 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (707 aa)
EDN2Endothelin 2. (177 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
LGMNLegumain. (433 aa)
THBS4Thrombospondin 4. (965 aa)
NOD2Uncharacterized protein. (982 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
SMOC2SPARC related modular calcium binding 2. (445 aa)
RAC2Rac family small GTPase 2. (192 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (826 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (767 aa)
TNFSF14TNF_2 domain-containing protein. (237 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (339 aa)
ENSCHIP00000022713Uncharacterized protein. (491 aa)
BST1Bone marrow stromal cell antigen 1. (333 aa)
GPSM3G protein signaling modulator 3. (162 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
IL34Interleukin 34. (233 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ARTNArtemin. (221 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
ATOH7Atonal bHLH transcription factor 7. (145 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
LBPLipopolysaccharide binding protein. (481 aa)
HABP2Hyaluronan binding protein 2. (558 aa)
STK39Serine/threonine kinase 39. (631 aa)
ANGPT2Angiopoietin 2. (498 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
MCUMitochondrial calcium uniporter. (351 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CCL19C-C motif chemokine. (102 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (775 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
THBS1Thrombospondin 1. (1218 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
PADI2Peptidyl arginine deiminase 2. (665 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (488 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
ROBO1Uncharacterized protein. (1474 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
LOC102181154C-C motif chemokine. (93 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1335 aa)
LOC102190717SCY domain-containing protein. (112 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (289 aa)
CXCL13C-X-C motif chemokine. (109 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (764 aa)
S100A14S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
CCL5C-C motif chemokine. (91 aa)
MTUS1Microtubule associated scaffold protein 1. (1302 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
AKIRIN1Akirin 1. (192 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
RIN3Ras and Rab interactor 3. (1031 aa)
GAS6Growth arrest specific 6. (671 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
DEF6DEF6 guanine nucleotide exchange factor. (632 aa)
CXCL10C-X-C motif chemokine. (102 aa)
MEGF8Multiple EGF like domains 8. (2836 aa)
CXCR3C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (367 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (722 aa)
LOC102179590C-C motif chemokine. (89 aa)
TMEM102Transmembrane protein 102. (513 aa)
MPP1Membrane palmitoylated protein 1; Belongs to the MAGUK family. (466 aa)
CD74CD74 molecule. (261 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (444 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (417 aa)
ADAM17ADAM metallopeptidase domain 17. (829 aa)
ENSCHIP00000011519Uncharacterized protein. (439 aa)
MYCBP2MYC binding protein 2. (4687 aa)
SEMA5ASemaphorin 5A. (1073 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
ENSCHIP00000010266Plexin_cytopl domain-containing protein. (255 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (356 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (266 aa)
POU4F2POU domain protein. (408 aa)
WNK1WNK lysine deficient protein kinase 1. (2367 aa)
FEZF2FEZ family zinc finger 2. (459 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TBR1T-box brain transcription factor 1. (682 aa)
KLRK1Killer cell lectin like receptor K1. (208 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CDH13Cadherin 13. (663 aa)
MOSPD2Motile sperm domain containing 2. (524 aa)
ENSCHIP00000007700Uncharacterized protein. (385 aa)
C5Complement C5. (1675 aa)
FGFR1Fibroblast growth factor receptor. (860 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
DSCAMDS cell adhesion molecule. (1852 aa)
NTRK3Tyrosine-protein kinase receptor. (825 aa)
SCG2Secretogranin II. (635 aa)
LOC102179713G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (338 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CMKLR1Chemerin chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
JAM3Junctional adhesion molecule 3. (329 aa)
CREB3cAMP responsive element binding protein 3. (368 aa)
RARRES2Chemerin. (162 aa)
NCKAP1LNCK associated protein 1 like. (1178 aa)
SLAMF1Ig-like domain-containing protein. (338 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
CXCL14C-X-C motif chemokine ligand 14. (99 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (626 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (316 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (476 aa)
RIPOR2Uncharacterized protein. (1052 aa)
ADAM10ADAM metallopeptidase domain 10. (750 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (387 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (610 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
FAM49BUncharacterized protein. (350 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
C5AR2Complement component 5a receptor 2. (337 aa)
ENSCHIP00000001557Ig-like domain-containing protein. (122 aa)
LOC102179993G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (355 aa)
TPBGTrophoblast glycoprotein. (420 aa)
ANO6Anoctamin. (931 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
ENSCHIP00000000870Ig-like domain-containing protein. (132 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
NOTCH1Notch receptor 1. (2508 aa)
SEMA5BSemaphorin 5B. (1043 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (826 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (764 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (140 aa)
PLXNA3Plexin A3. (1822 aa)
LYNTyrosine-protein kinase. (512 aa)
CCL27C-C motif chemokine ligand 27. (108 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (762 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (330 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (418 aa)
F7Coagulation factor VII. (447 aa)
C1QBPComplement C1q binding protein. (278 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (920 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (964 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
MMP28Matrix metallopeptidase 28. (521 aa)
PTNPleiotrophin. (183 aa)
STAP1Signal transducing adaptor family member 1. (300 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
OCM2Uncharacterized protein; Belongs to the parvalbumin family. (132 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
SLIT2Slit guidance ligand 2. (1457 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSCHIP00000031698Uncharacterized protein. (321 aa)
LOC102190981SCY domain-containing protein. (109 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
HRGHistidine rich glycoprotein. (531 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (769 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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