STRINGSTRING
SHLD2 SHLD2 SMCHD1 SMCHD1 TIPIN TIPIN H1-5 H1-5 ENSCHIP00000001374 ENSCHIP00000001374 ENSCHIP00000001595 ENSCHIP00000001595 DACH1 DACH1 HNRNPU HNRNPU NUDT16L1 NUDT16L1 CDKN1A CDKN1A SRC SRC H1-4 H1-4 RNF169 RNF169 RAD50 RAD50 GZMA GZMA NIBAN2 NIBAN2 TNKS TNKS SUB1 SUB1 LOC102170015 LOC102170015 TEN1 TEN1 HSF1 HSF1 RECQL5 RECQL5 ERCC6 ERCC6 ENSCHIP00000006184 ENSCHIP00000006184 TP53BP1 TP53BP1 BLM BLM DFFB DFFB H1-6 H1-6 TIMELESS TIMELESS H1-3 H1-3 MAD2L2 MAD2L2 NBN NBN LOC102181348 LOC102181348 DCP2 DCP2 LOC102188481 LOC102188481 TERF1 TERF1 LOC102189034 LOC102189034 RPS3 RPS3 H1-1 H1-1 TRIM28 TRIM28 CDT1 CDT1 ZNF830 ZNF830 ENSCHIP00000010204 ENSCHIP00000010204 LOC102184761 LOC102184761 TRIP12 TRIP12 MEN1 MEN1 WAPL WAPL POLQ POLQ HMGA2 HMGA2 RTEL1 RTEL1 MSH6 MSH6 OTUB1 OTUB1 FOXP3 FOXP3 NRM NRM PIF1 PIF1 POT1 POT1 AUNIP AUNIP SHLD1 SHLD1 TSPYL2 TSPYL2 UBQLN4 UBQLN4 H1-8 H1-8 THOC1 THOC1 FANCB FANCB ENSCHIP00000015226 ENSCHIP00000015226 PARP3 PARP3 FBH1 FBH1 ATM ATM LOC102178151 LOC102178151 CCDC197 CCDC197 SLX4 SLX4 KMT2A KMT2A ENSCHIP00000018363 ENSCHIP00000018363 GDF2 GDF2 MAGEF1 MAGEF1 CGAS CGAS ANKRD1 ANKRD1 CYREN CYREN STN1 STN1 GMNN GMNN EXOSC10 EXOSC10 BMPR2 BMPR2 RIF1 RIF1 MCIDAS MCIDAS ENSCHIP00000022338 ENSCHIP00000022338 DONSON DONSON OTUB2 OTUB2 XRCC1 XRCC1 RAD17 RAD17 LOC102175542 LOC102175542 UBR5 UBR5 CERS1 CERS1 TERF2IP TERF2IP TNKS2 TNKS2 BRCA2 BRCA2 ENSCHIP00000024183 ENSCHIP00000024183 KLHL15 KLHL15 RMI2 RMI2 RADX RADX H1-2 H1-2 MSH2 MSH2 ATR ATR SMG6 SMG6 XRCC5 XRCC5 ENPP7 ENPP7 ERCC4 ERCC4 OGG1 OGG1 PARPBP PARPBP GMNC GMNC CDAN1 CDAN1 TINF2 TINF2 LIG3 LIG3 TERF2 TERF2 CTC1 CTC1 TP53 TP53 GATA3 GATA3 HNRNPA1 HNRNPA1 SMARCAL1 SMARCAL1 NDFIP1 NDFIP1 ACD ACD ERCC1 ERCC1 ZRANB3 ZRANB3 ENSCHIP00000031621 ENSCHIP00000031621 NAT10 NAT10 PDS5A PDS5A DNMT3L DNMT3L BCL6 BCL6 PINX1 PINX1 MSH3 MSH3 ADIPOQ ADIPOQ FBXO5 FBXO5 ACVRL1 ACVRL1 HELB HELB FLCN FLCN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHLD2Shieldin complex subunit 2. (918 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
ENSCHIP00000001374Uncharacterized protein. (222 aa)
ENSCHIP00000001595Uncharacterized protein. (333 aa)
DACH1Dachshund family transcription factor 1. (761 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
NUDT16L1Nudix hydrolase 16 like 1. (211 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
SRCTyrosine-protein kinase. (538 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
RNF169Ring finger protein 169. (708 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (259 aa)
NIBAN2Niban apoptosis regulator 2. (744 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
SUB1SUB1 regulator of transcription. (127 aa)
LOC102170015Uncharacterized protein. (384 aa)
TEN1Uncharacterized protein. (123 aa)
HSF1HSF_DOMAIN domain-containing protein. (537 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
ENSCHIP00000006184Uncharacterized protein. (96 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
BLMBLM RecQ like helicase. (1429 aa)
DFFBDNA fragmentation factor subunit beta. (370 aa)
H1-6Histone cluster 1 H1 family member t. (210 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
H1-3Histone cluster 1 H1 family member d. (221 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (195 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
LOC102181348H15 domain-containing protein. (210 aa)
DCP2Decapping mRNA 2. (423 aa)
LOC102188481Uncharacterized protein. (379 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
LOC102189034Uncharacterized protein. (320 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
H1-1Histone cluster 1 H1 family member a. (218 aa)
TRIM28Tripartite motif containing 28. (837 aa)
CDT1Chromatin licensing and DNA replication factor 1. (637 aa)
ZNF830Zinc finger protein 830. (361 aa)
ENSCHIP00000010204TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa)
LOC102184761Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (260 aa)
TRIP12Thyroid hormone receptor interactor 12. (2067 aa)
MEN1Menin 1. (609 aa)
WAPLWAPL cohesin release factor. (1193 aa)
POLQDNA polymerase theta. (2587 aa)
HMGA2Uncharacterized protein. (104 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
OTUB1Ubiquitin thioesterase. (271 aa)
FOXP3Forkhead box P3. (463 aa)
NRMNurim. (262 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
POT1Protection of telomeres 1. (785 aa)
AUNIPAurora kinase A and ninein interacting protein. (357 aa)
SHLD1Shieldin complex subunit 1. (206 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (699 aa)
UBQLN4Ubiquilin 4. (601 aa)
H1-8H1 histone family member O oocyte specific. (333 aa)
THOC1THO complex 1. (657 aa)
FANCBUncharacterized protein. (447 aa)
ENSCHIP00000015226KH type-2 domain-containing protein. (204 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
FBH1F-box DNA helicase 1. (1048 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
LOC102178151Uncharacterized protein. (163 aa)
CCDC197Coiled-coil domain containing 197. (288 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1752 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3871 aa)
ENSCHIP00000018363Uncharacterized protein. (331 aa)
GDF2Growth differentiation factor 2. (430 aa)
MAGEF1MAGE family member F1. (299 aa)
CGASCyclic GMP-AMP synthase. (511 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
CYRENCell cycle regulator of NHEJ. (144 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (370 aa)
GMNNGeminin DNA replication inhibitor. (186 aa)
EXOSC10Exosome component 10. (844 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
MCIDASMulticiliate differentiation and DNA synthesis associated cell cycle protein. (374 aa)
ENSCHIP00000022338Uncharacterized protein. (300 aa)
DONSONDownstream neighbor of SON. (561 aa)
OTUB2OTU deubiquitinase, ubiquitin aldehyde binding 2. (234 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
RAD17RAD17 checkpoint clamp loader component. (709 aa)
LOC102175542Uncharacterized protein. (307 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2801 aa)
CERS1TLC domain-containing protein. (333 aa)
TERF2IPUncharacterized protein. (400 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
ENSCHIP00000024183Uncharacterized protein. (207 aa)
KLHL15Kelch like family member 15. (604 aa)
RMI2Uncharacterized protein. (161 aa)
RADXRPA1 related single stranded DNA binding protein, X-linked. (764 aa)
H1-2Histone cluster 1 H1 family member c. (227 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1411 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (435 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
OGG18-oxoguanine DNA glycosylase. (345 aa)
PARPBPPARP1 binding protein. (580 aa)
GMNCGeminin coiled-coil domain containing. (336 aa)
CDAN1Codanin 1. (1230 aa)
TINF2TERF1 interacting nuclear factor 2. (458 aa)
LIG3DNA ligase. (1004 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
GATA3GATA binding protein 3. (467 aa)
HNRNPA1Uncharacterized protein. (320 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1070 aa)
ENSCHIP00000031621Uncharacterized protein. (159 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
PDS5APDS5 cohesin associated factor A. (1337 aa)
DNMT3LPHD-type domain-containing protein. (390 aa)
BCL6BCL6 transcription repressor. (706 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa)
ADIPOQC1q domain-containing protein. (283 aa)
FBXO5F-box protein 5. (448 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
HELBDNA helicase B. (1077 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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