STRINGSTRING
TRIM32 TRIM32 CAV3 CAV3 FRS2 FRS2 SIRT1 SIRT1 MMP14 MMP14 ZBED6 ZBED6 SMAD1 SMAD1 SETD3 SETD3 PI16 PI16 EDN1 EDN1 TMEM119 TMEM119 BMP2 BMP2 SIK1 SIK1 FOXO4 FOXO4 NFATC2 NFATC2 RBM24 RBM24 ACTN3 ACTN3 MSX1 MSX1 MYF5 MYF5 LOC108633232 LOC108633232 DMPK DMPK ARRB2 ARRB2 SHOX2 SHOX2 WNT3A WNT3A MEF2C MEF2C BCL2 BCL2 ZEB1 ZEB1 HDAC5 HDAC5 SMYD1 SMYD1 CYP26B1 CYP26B1 NEK5 NEK5 NKX2-5 NKX2-5 LMOD3 LMOD3 MAMSTR MAMSTR PLPP7 PLPP7 PTBP1 PTBP1 CAMK1 CAMK1 ANKRD17 ANKRD17 HDAC4 HDAC4 IGF1 IGF1 SMAD4 SMAD4 OLFM2 OLFM2 MTOR MTOR BMPR2 BMPR2 RBM4 RBM4 DLL1 DLL1 AKIRIN2 AKIRIN2 IGF2 IGF2 NFATC1 NFATC1 TRIM72 TRIM72 BMP4 BMP4 NOTCH1 NOTCH1 MYOCD MYOCD MYOG MYOG PROX1 PROX1 MYF6 MYF6 SOX6 SOX6 PDCD4 PDCD4 KIT KIT GPER1 GPER1 NFATC3 NFATC3 MECP2 MECP2 DNMT1 DNMT1 SHH SHH TARBP2 TARBP2 MED28 MED28 BMP10 BMP10 FZD7 FZD7 ENG ENG GSK3A GSK3A BHLHE41 BHLHE41 RBPMS2 RBPMS2 NLN NLN MAML1 MAML1 CDK9 CDK9 SUPT6H SUPT6H PRDM6 PRDM6 MEGF10 MEGF10 FBXO22 FBXO22 PDGFB PDGFB ATP11A ATP11A BMPR1A BMPR1A EREG EREG RBM38 RBM38 HOPX HOPX OR10J5 OR10J5 EZH2 EZH2 CCDC142 CCDC142 MESP1 MESP1 BHLHA15 BHLHA15 ENSCHIP00000005279 ENSCHIP00000005279 MYOD1 MYOD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM32Tripartite motif containing 32. (695 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
MMP14ZnMc domain-containing protein. (584 aa)
ZBED6Zinc finger BED-type containing 6. (980 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SETD3Protein-histidine N-methyltransferase. (594 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (464 aa)
EDN1Endothelin 1. (202 aa)
TMEM119Transmembrane protein 119. (284 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
SIK1Uncharacterized protein. (778 aa)
FOXO4Forkhead box O4. (535 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
RBM24RNA binding motif protein 24. (248 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
MSX1Msh homeobox 1. (303 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (260 aa)
LOC108633232Protein-histidine N-methyltransferase. (578 aa)
DMPKDM1 protein kinase. (616 aa)
ARRB2Arrestin beta 2. (420 aa)
SHOX2Short stature homeobox 2. (319 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1142 aa)
SMYD1SET and MYND domain containing 1. (494 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
NEK5NIMA related kinase 5. (715 aa)
NKX2-5NK2 homeobox 5. (323 aa)
LMOD3Leiomodin 3. (567 aa)
MAMSTRMEF2 activating motif and SAP domain containing transcriptional regulator. (416 aa)
PLPP7Phospholipid phosphatase 7 (inactive). (271 aa)
PTBP1Polypyrimidine tract binding protein 1. (557 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
ANKRD17Ankyrin repeat domain 17. (2604 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
OLFM2Olfactomedin 2. (478 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
RBM4RNA binding motif protein 4. (362 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
AKIRIN2Akirin 2. (222 aa)
IGF2Insulin-like growth factor II. (179 aa)
NFATC1Nuclear factor of activated T cells 1. (1002 aa)
TRIM72Tripartite motif containing 72. (487 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NOTCH1Notch receptor 1. (2508 aa)
MYOCDMyocardin. (982 aa)
MYOGMyogenin. (224 aa)
PROX1Prospero homeobox 1. (734 aa)
MYF6BHLH domain-containing protein. (242 aa)
SOX6SRY-box transcription factor 6. (858 aa)
PDCD4Programmed cell death 4. (513 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (370 aa)
MED28Mediator complex subunit 28. (178 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
ENGEndoglin. (649 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
BHLHE41Basic helix-loop-helix family member e41. (487 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (197 aa)
NLNNeurolysin. (705 aa)
MAML1Mastermind like transcriptional coactivator 1. (1018 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
PRDM6PR/SET domain 6. (591 aa)
MEGF10Multiple EGF like domains 10. (1135 aa)
FBXO22F-box protein 22. (405 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1146 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EREGEpiregulin. (163 aa)
RBM38RNA binding motif protein 38. (242 aa)
HOPXHomeobox domain-containing protein. (73 aa)
OR10J5Olfactory receptor family 10 subfamily J member 5. (309 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
CCDC142Coiled-coil domain containing 142. (725 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
BHLHA15Basic helix-loop-helix family member a15. (186 aa)
ENSCHIP00000005279RRM domain-containing protein. (80 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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