STRINGSTRING
ZMPSTE24 ZMPSTE24 BMPR1A BMPR1A EPYC EPYC CYTL1 CYTL1 SERPINH1 SERPINH1 HAND1 HAND1 RB1 RB1 PITX1 PITX1 HOXA5 HOXA5 BGN BGN GPLD1 GPLD1 PTH1R PTH1R HYAL2 HYAL2 ZBTB16 ZBTB16 IL17F IL17F MATN1 MATN1 WNT2B WNT2B EXT1 EXT1 DDRGK1 DDRGK1 NOG NOG COL2A1 COL2A1 PRRX1 PRRX1 MEF2D MEF2D SIX2 SIX2 FGF4 FGF4 CBS CBS ECM1 ECM1 WNT10B WNT10B THRA THRA SMAD1 SMAD1 ATF2 ATF2 FGF18 FGF18 TGFBR2 TGFBR2 HOXD3 HOXD3 CNMD CNMD RARB RARB EDN1 EDN1 TGFB1 TGFB1 SRF SRF NFIB NFIB HAND2 HAND2 IMPAD1 IMPAD1 GDF5 GDF5 ENSCHIP00000009938 ENSCHIP00000009938 PBXIP1 PBXIP1 BMP2 BMP2 TAPT1 TAPT1 FGF6 FGF6 TRPV4 TRPV4 HMGA2 HMGA2 HOXB3 HOXB3 MSX1 MSX1 HOXA3 HOXA3 SNAI1 SNAI1 WNT5B WNT5B SULF2 SULF2 RARA RARA SMAD5 SMAD5 MYF5 MYF5 SNORC SNORC CHRDL2 CHRDL2 COMP COMP GLI3 GLI3 CHST11 CHST11 SDC3 SDC3 HIF1A HIF1A THBS3 THBS3 CREB3L2 CREB3L2 RUNX2 RUNX2 MAPK3 MAPK3 SHOX2 SHOX2 MEF2C MEF2C OGN OGN PKD1 PKD1 ZEB1 ZEB1 ANXA6 ANXA6 IHH IHH CER1 CER1 RUNX1 RUNX1 HYAL3 HYAL3 SCUBE2 SCUBE2 BMPR1B BMPR1B MGP MGP MEX3C MEX3C MATN3 MATN3 FGF2 FGF2 OSR2 OSR2 ITGB8 ITGB8 SMPD3 SMPD3 OSR1 OSR1 BMPR2 BMPR2 ADAMTS12 ADAMTS12 AXIN2 AXIN2 HOXA11 HOXA11 BBS2 BBS2 FGF9 FGF9 MUSTN1 MUSTN1 ACAN ACAN MMP13 MMP13 BMP4 BMP4 COL1A1 COL1A1 NPPC NPPC CD44 CD44 SOX9 SOX9 OTOR OTOR BARX2 BARX2 HES5 HES5 WNT7A WNT7A SATB2 SATB2 SFRP2 SFRP2 SNX19 SNX19 HYAL1 HYAL1 RARG RARG LTBP3 LTBP3 SLC39A14 SLC39A14 TRIP11 TRIP11 MKKS MKKS RUNX3 RUNX3 ENSCHIP00000029297 ENSCHIP00000029297 DLX2 DLX2 CSGALNACT1 CSGALNACT1 IFT80 IFT80 BMP3 BMP3 CCN2 CCN2 BBS1 BBS1 CTNNB1 CTNNB1 EXT2 EXT2 ARID5A ARID5A HOXC4 HOXC4 TWSG1 TWSG1 SULF1 SULF1 CCN1 CCN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EPYCEpiphycan. (321 aa)
CYTL1Cytokine like 1. (136 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
HAND1Heart and neural crest derivatives expressed 1. (219 aa)
RB1RB transcriptional corepressor 1. (931 aa)
PITX1Homeobox protein. (314 aa)
HOXA5Homeobox A5. (270 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (848 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (589 aa)
HYAL2Hyaluronidase. (476 aa)
ZBTB16Uncharacterized protein. (673 aa)
IL17FUncharacterized protein. (178 aa)
MATN1Matrilin 1. (480 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
DDRGK1DDRGK domain containing 1. (298 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
COL2A1Collagen type II alpha 1 chain. (1259 aa)
PRRX1Paired related homeobox 1. (245 aa)
MEF2DMADS-box domain-containing protein. (513 aa)
SIX2SIX homeobox 2. (296 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (586 aa)
ECM1Extracellular matrix protein 1. (524 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
THRAThyroid hormone receptor alpha. (511 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
HOXD3Homeobox D3. (433 aa)
CNMDChondromodulin. (335 aa)
RARBRetinoic acid receptor beta. (448 aa)
EDN1Endothelin 1. (202 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SRFSerum response factor. (509 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
IMPAD1Inositol monophosphatase domain containing 1. (425 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSCHIP00000009938Annexin. (100 aa)
PBXIP1PBX homeobox interacting protein 1. (726 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
TAPT1Transmembrane anterior posterior transformation 1. (564 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
HMGA2Uncharacterized protein. (104 aa)
HOXB3Homeobox B3. (426 aa)
MSX1Msh homeobox 1. (303 aa)
HOXA3Homeobox A3. (437 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
SULF2Sulfatase 2. (864 aa)
RARARetinoic acid receptor alpha. (462 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (260 aa)
SNORCSecondary ossification center associated regulator of chondrocyte maturation. (118 aa)
CHRDL2Chordin like 2. (430 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
GLI3GLI family zinc finger 3. (1614 aa)
CHST11Carbohydrate sulfotransferase. (362 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (442 aa)
HIF1AUncharacterized protein. (823 aa)
THBS3Thrombospondin 3. (984 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
SHOX2Short stature homeobox 2. (319 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
OGNUncharacterized protein. (299 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
ANXA6Annexin. (689 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
CER1Cerberus 1, DAN family BMP antagonist. (263 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
HYAL3Hyaluronidase. (419 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1022 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (101 aa)
MEX3CMex-3 RNA binding family member C. (664 aa)
MATN3Matrilin 3. (485 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (772 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1605 aa)
AXIN2Axin 2. (844 aa)
HOXA11Homeobox A11. (317 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (730 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MUSTN1Uncharacterized protein. (86 aa)
ACANAggrecan. (2402 aa)
MMP13Matrix metallopeptidase 13. (472 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
NPPCNatriuretic peptide C. (126 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
SOX9SRY-box transcription factor 9. (525 aa)
OTOROtoraplin. (129 aa)
BARX2BARX homeobox 2. (278 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SATB2DNA-binding protein SATB. (733 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
SNX19Sorting nexin 19. (1057 aa)
HYAL1Hyaluronidase. (450 aa)
RARGRetinoic acid receptor gamma. (458 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1294 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
TRIP11Thyroid hormone receptor interactor 11. (1975 aa)
MKKSMcKusick-Kaufman syndrome. (573 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (435 aa)
ENSCHIP00000029297Syndecan domain-containing protein. (407 aa)
DLX2Distal-less homeobox 2. (328 aa)
CSGALNACT1Hexosyltransferase. (524 aa)
IFT80Intraflagellar transport 80. (771 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (467 aa)
CCN2Cellular communication network factor 2. (349 aa)
BBS1BBS1 domain-containing protein. (592 aa)
CTNNB1Catenin beta 1. (781 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (737 aa)
ARID5AAT-rich interaction domain 5A. (591 aa)
HOXC4Homeobox C4. (264 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)
CCN1Cellular communication network factor 1. (382 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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