(22 nodes) Regulation of histone H3-K9 methylation network (Capra hircus)

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	SETD7	SET domain containing 7, histone lysine methyltransferase. (407 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1258 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1268 aa)
	ATRX	ATRX chromatin remodeler. (2105 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (665 aa)
	KDM4A	Uncharacterized protein. (1067 aa)
	KDM3A	Lysine demethylase 3A. (1362 aa)
	PIH1D1	PIH1 domain containing 1. (290 aa)
	RIF1	Replication timing regulatory factor 1. (2486 aa)
	DMRTC2	DMRT like family C2. (370 aa)
	SMARCB1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (395 aa)
	PAX5	Paired box 5. (392 aa)
	ZNF274	Zinc finger protein 274. (611 aa)
	ZNF304	Zinc finger protein 304. (662 aa)
	KDM4B	Lysine demethylase 4B. (1070 aa)
	PRDM12	PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (362 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	EHMT1	Euchromatic histone lysine methyltransferase 1. (1293 aa)
	MYB	MYB proto-oncogene, transcription factor. (640 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	BRCA1	ENSCHIP00000011584	ENSCHIP00000033014	ATRX chromatin remodeler.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.599
ATRX	DNMT1	ENSCHIP00000011584	ENSCHIP00000027359	ATRX chromatin remodeler.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.710
ATRX	MECP2	ENSCHIP00000011584	ENSCHIP00000026916	ATRX chromatin remodeler.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.827
BRCA1	ATRX	ENSCHIP00000033014	ENSCHIP00000011584	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATRX chromatin remodeler.	0.599
BRCA1	DNMT1	ENSCHIP00000033014	ENSCHIP00000027359	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.630
BRCA1	LMNA	ENSCHIP00000033014	ENSCHIP00000026441	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Lamin A/C; Belongs to the intermediate filament family.	0.513
BRCA1	RIF1	ENSCHIP00000033014	ENSCHIP00000022306	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Replication timing regulatory factor 1.	0.617
BRCA1	SIRT1	ENSCHIP00000033014	ENSCHIP00000007571	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Deacetylase sirtuin-type domain-containing protein.	0.505
DNMT1	ATRX	ENSCHIP00000027359	ENSCHIP00000011584	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	ATRX chromatin remodeler.	0.710
DNMT1	BRCA1	ENSCHIP00000027359	ENSCHIP00000033014	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.630
DNMT1	EHMT1	ENSCHIP00000027359	ENSCHIP00000007034	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Euchromatic histone lysine methyltransferase 1.	0.705
DNMT1	EHMT2	ENSCHIP00000027359	ENSCHIP00000011002	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Euchromatic histone lysine methyltransferase 2.	0.764
DNMT1	JARID2	ENSCHIP00000027359	ENSCHIP00000003243	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Jumonji and AT-rich interaction domain containing 2.	0.651
DNMT1	MECP2	ENSCHIP00000027359	ENSCHIP00000026916	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.943
DNMT1	SETD7	ENSCHIP00000027359	ENSCHIP00000005443	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	SET domain containing 7, histone lysine methyltransferase.	0.685
DNMT1	SIRT1	ENSCHIP00000027359	ENSCHIP00000007571	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Deacetylase sirtuin-type domain-containing protein.	0.661
DNMT1	ZNF304	ENSCHIP00000027359	ENSCHIP00000017610	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Zinc finger protein 304.	0.643
EHMT1	DNMT1	ENSCHIP00000007034	ENSCHIP00000027359	Euchromatic histone lysine methyltransferase 1.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.705
EHMT1	EHMT2	ENSCHIP00000007034	ENSCHIP00000011002	Euchromatic histone lysine methyltransferase 1.	Euchromatic histone lysine methyltransferase 2.	0.998
EHMT1	JARID2	ENSCHIP00000007034	ENSCHIP00000003243	Euchromatic histone lysine methyltransferase 1.	Jumonji and AT-rich interaction domain containing 2.	0.414