(45 nodes) Cardiac muscle tissue morphogenesis network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POU4F1	POU domain protein. (421 aa)
	TCAP	Uncharacterized protein. (167 aa)
	RYR2	Ryanodine receptor 2. (4943 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	ENG	Endoglin. (649 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	MYL10	Myosin light chain 10. (222 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	MYBPC3	Myosin binding protein C, cardiac. (1303 aa)
	PROX1	Prospero homeobox 1. (734 aa)
	MYH7	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1955 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	TNNT2	Troponin T2, cardiac type. (267 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	SMAD7	Mothers against decapentaplegic homolog. (427 aa)
	TNNC1	Uncharacterized protein. (154 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	LRP2	LDL receptor related protein 2. (4649 aa)
	ANKRD1	Ankyrin repeat domain 1. (319 aa)
	ACTC1	Actin alpha cardiac muscle 1. (377 aa)
	S1PR1	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (988 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	TBX20	T-box transcription factor 20. (449 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2993 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (219 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	BMP2	TGF_BETA_2 domain-containing protein. (381 aa)
	DSP	Desmoplakin. (2892 aa)
	MYL3	Myosin light chain 3. (194 aa)
	PKP2	Plakophilin 2. (851 aa)
	ENSCHIP00000013896	Uncharacterized protein. (179 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
	FOXH1	Forkhead box H1. (360 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1022 aa)
	EGLN1	Uncharacterized protein. (422 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	TNNI1	Troponin I1, slow skeletal type. (187 aa)
	MYLK2	Myosin light chain kinase 2. (632 aa)
	MYH6	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	MYBPC3	ENSCHIP00000002085	ENSCHIP00000025176	Actin alpha cardiac muscle 1.	Myosin binding protein C, cardiac.	0.750
ACTC1	MYH6	ENSCHIP00000002085	ENSCHIP00000017471	Actin alpha cardiac muscle 1.	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.999
ACTC1	MYH7	ENSCHIP00000002085	ENSCHIP00000024142	Actin alpha cardiac muscle 1.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.999
ACTC1	MYL3	ENSCHIP00000002085	ENSCHIP00000011928	Actin alpha cardiac muscle 1.	Myosin light chain 3.	0.760
ACTC1	MYLK2	ENSCHIP00000002085	ENSCHIP00000017135	Actin alpha cardiac muscle 1.	Myosin light chain kinase 2.	0.406
ACTC1	NKX2-5	ENSCHIP00000002085	ENSCHIP00000017688	Actin alpha cardiac muscle 1.	NK2 homeobox 5.	0.554
ACTC1	RYR2	ENSCHIP00000002085	ENSCHIP00000033577	Actin alpha cardiac muscle 1.	Ryanodine receptor 2.	0.661
ACTC1	TBX20	ENSCHIP00000002085	ENSCHIP00000007813	Actin alpha cardiac muscle 1.	T-box transcription factor 20.	0.495
ACTC1	TNNI1	ENSCHIP00000002085	ENSCHIP00000016174	Actin alpha cardiac muscle 1.	Troponin I1, slow skeletal type.	0.553
ACTC1	TNNT2	ENSCHIP00000002085	ENSCHIP00000022908	Actin alpha cardiac muscle 1.	Troponin T2, cardiac type.	0.817
ANKRD1	MYBPC3	ENSCHIP00000019764	ENSCHIP00000025176	Ankyrin repeat domain 1.	Myosin binding protein C, cardiac.	0.439
ANKRD1	MYH6	ENSCHIP00000019764	ENSCHIP00000017471	Ankyrin repeat domain 1.	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.581
ANKRD1	MYH7	ENSCHIP00000019764	ENSCHIP00000024142	Ankyrin repeat domain 1.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.638
ANKRD1	MYLK2	ENSCHIP00000019764	ENSCHIP00000017135	Ankyrin repeat domain 1.	Myosin light chain kinase 2.	0.411
ANKRD1	RYR2	ENSCHIP00000019764	ENSCHIP00000033577	Ankyrin repeat domain 1.	Ryanodine receptor 2.	0.464
ANKRD1	TCAP	ENSCHIP00000019764	ENSCHIP00000001814	Ankyrin repeat domain 1.	Uncharacterized protein.	0.562
ANKRD1	TNNT2	ENSCHIP00000019764	ENSCHIP00000022908	Ankyrin repeat domain 1.	Troponin T2, cardiac type.	0.457
BMP10	BMPR1A	ENSCHIP00000031863	ENSCHIP00000000640	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.621
BMP10	ENG	ENSCHIP00000031863	ENSCHIP00000033223	Bone morphogenetic protein 10.	Endoglin.	0.773
BMP10	NKX2-5	ENSCHIP00000031863	ENSCHIP00000017688	Bone morphogenetic protein 10.	NK2 homeobox 5.	0.440