STRINGSTRING
TCF7 TCF7 DIXDC1 DIXDC1 LGR4 LGR4 RSPO3 RSPO3 DVL3 DVL3 FZD1 FZD1 SOSTDC1 SOSTDC1 EDN1 EDN1 CDH3 CDH3 EDNRB EDNRB WNT2 WNT2 WNT10B WNT10B EDA EDA STK3 STK3 TCF7L1 TCF7L1 AXIN1 AXIN1 BCL9 BCL9 TCF7L2 TCF7L2 WNT9A WNT9A EXT1 EXT1 WNT2B WNT2B SFRP4 SFRP4 FZD10 FZD10 FRAT1 FRAT1 FZD5 FZD5 CTDNEP1 CTDNEP1 BCL9L BCL9L STK4 STK4 FZD9 FZD9 WNT8A WNT8A WNT5B WNT5B GSK3B GSK3B WNT7B WNT7B CBY1 CBY1 LRP6 LRP6 LOC102181663 LOC102181663 DVL1 DVL1 SIAH2 SIAH2 WNT5A WNT5A WNT3A WNT3A WNT16 WNT16 YAP1 YAP1 FZD6 FZD6 RAPGEF1 RAPGEF1 FGF2 FGF2 FOXO3 FOXO3 GPC3 GPC3 SDC1 SDC1 WNT3 WNT3 WNT1 WNT1 CAV1 CAV1 ENSCHIP00000021059 ENSCHIP00000021059 LRP5 LRP5 EDNRA EDNRA SFRP1 SFRP1 SOST SOST FGF9 FGF9 LATS2 LATS2 FRZB FRZB SOX9 SOX9 WNT11 WNT11 RECK RECK WNT8B WNT8B SCYL2 SCYL2 WNT7A WNT7A ISL1 ISL1 PLPP3 PLPP3 WNT10A WNT10A SFRP2 SFRP2 LOC102180576 LOC102180576 WNT6 WNT6 FZD3 FZD3 SHH SHH HESX1 HESX1 SFRP5 SFRP5 PYGO1 PYGO1 GATA3 GATA3 LEF1 LEF1 ENSCHIP00000030683 ENSCHIP00000030683 RAB5A RAB5A CTNNB1 CTNNB1 DVL2 DVL2 FZD4 FZD4 FZD7 FZD7 JUP JUP WNT4 WNT4 FZD8 FZD8 WNT9B WNT9B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF7Transcription factor 7. (418 aa)
DIXDC1DIX domain containing 1. (689 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
RSPO3R-spondin 3. (303 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
EDN1Endothelin 1. (202 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (831 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (257 aa)
STK3Serine/threonine kinase 3. (495 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
AXIN1Axin 1. (867 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FRAT1Uncharacterized protein. (276 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
BCL9LBCL9 like. (1495 aa)
STK4Serine/threonine kinase 4. (487 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
CBY1Uncharacterized protein. (127 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
LOC102181663Uncharacterized protein. (119 aa)
DVL1Dishevelled segment polarity protein 1. (682 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (333 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
YAP1Yes associated protein 1. (503 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1077 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FOXO3Forkhead box O3. (672 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (312 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSCHIP00000021059Uncharacterized protein. (63 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
SOSTSclerostin. (212 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LATS2Large tumor suppressor kinase 2. (1015 aa)
FRZBFrizzled related protein. (325 aa)
SOX9SRY-box transcription factor 9. (525 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
SCYL2SCY1 like pseudokinase 2. (866 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
LOC102180576Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
HESX1HESX homeobox 1. (185 aa)
SFRP5Secreted frizzled related protein 5. (320 aa)
PYGO1Pygopus family PHD finger 1. (412 aa)
GATA3GATA binding protein 3. (467 aa)
LEF1HMG box domain-containing protein. (430 aa)
ENSCHIP00000030683Uncharacterized protein. (66 aa)
RAB5AUncharacterized protein. (215 aa)
CTNNB1Catenin beta 1. (781 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
JUPJunction plakoglobin. (745 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (665 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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