7 items (Capra hircus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	NMI	N-myc and STAT interactor. (309 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	IFNGR1	Interferon gamma receptor 1. (500 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	HPX	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNG	IFNGR1	ENSCHIP00000016152	ENSCHIP00000011719	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Interferon gamma receptor 1.	0.999
IFNG	IRF1	ENSCHIP00000016152	ENSCHIP00000021648	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Interferon regulatory factor.	0.846
IFNG	STAT1	ENSCHIP00000016152	ENSCHIP00000005767	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Signal transducer and activator of transcription.	0.964
IFNG	TP53	ENSCHIP00000016152	ENSCHIP00000030141	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.797
IFNGR1	IFNG	ENSCHIP00000011719	ENSCHIP00000016152	Interferon gamma receptor 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.999
IFNGR1	IRF1	ENSCHIP00000011719	ENSCHIP00000021648	Interferon gamma receptor 1.	Interferon regulatory factor.	0.627
IFNGR1	STAT1	ENSCHIP00000011719	ENSCHIP00000005767	Interferon gamma receptor 1.	Signal transducer and activator of transcription.	0.996
IRF1	IFNG	ENSCHIP00000021648	ENSCHIP00000016152	Interferon regulatory factor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.846
IRF1	IFNGR1	ENSCHIP00000021648	ENSCHIP00000011719	Interferon regulatory factor.	Interferon gamma receptor 1.	0.627
IRF1	STAT1	ENSCHIP00000021648	ENSCHIP00000005767	Interferon regulatory factor.	Signal transducer and activator of transcription.	0.990
IRF1	TP53	ENSCHIP00000021648	ENSCHIP00000030141	Interferon regulatory factor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.530
NMI	STAT1	ENSCHIP00000030661	ENSCHIP00000005767	N-myc and STAT interactor.	Signal transducer and activator of transcription.	0.493
STAT1	IFNG	ENSCHIP00000005767	ENSCHIP00000016152	Signal transducer and activator of transcription.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.964
STAT1	IFNGR1	ENSCHIP00000005767	ENSCHIP00000011719	Signal transducer and activator of transcription.	Interferon gamma receptor 1.	0.996
STAT1	IRF1	ENSCHIP00000005767	ENSCHIP00000021648	Signal transducer and activator of transcription.	Interferon regulatory factor.	0.990
STAT1	NMI	ENSCHIP00000005767	ENSCHIP00000030661	Signal transducer and activator of transcription.	N-myc and STAT interactor.	0.493
STAT1	TP53	ENSCHIP00000005767	ENSCHIP00000030141	Signal transducer and activator of transcription.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.841
TP53	IFNG	ENSCHIP00000030141	ENSCHIP00000016152	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.797
TP53	IRF1	ENSCHIP00000030141	ENSCHIP00000021648	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Interferon regulatory factor.	0.530
TP53	STAT1	ENSCHIP00000030141	ENSCHIP00000005767	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Signal transducer and activator of transcription.	0.841